Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats

Metabolic Brain Disease

Volumn 31, Issue 4, 2016, Pages 779-791

  Zhuo, Yeye ^a,b   Guo, Haibiao ^a   Cheng, Yufang ^a   Wang, Chuang ^c   Wang, Canmao ^d   Wu, Jingang ^a   Zou, Zhengqiang ^a   Gan, Danna ^d   Li, Yiwen ^a   Xu, Jiangping ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^c Ningbo Key Laboratory of Behavioral Neuroscience   (China)

^d SHENZHEN HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Memory; Oxidative stress; Phosphodiesterase 4; Rolipram; amyloid

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; ANTIOXIDANT; GLUTATHIONE; INOSINATE DEHYDROGENASE; MALONALDEHYDE; NEUROPROTECTIVE AGENT; PHOSPHODIESTERASE IV; REACTIVE OXYGEN METABOLITE; ROLIPRAM; SUPEROXIDE DISMUTASE; THIOREDOXIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (25-35); INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEPTIDE FRAGMENT; PHOSPHODIESTERASE IV INHIBITOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC DRUG ADMINISTRATION; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; LATENT PERIOD; LOCOMOTION; LONG TERM CARE; LONG TERM MEMORY; MALE; MEMORY DISORDER; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; AVOIDANCE BEHAVIOR; CHEMICALLY INDUCED; COGNITION; DISEASE MODEL; DRUG EFFECTS; MAZE TEST; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; AVOIDANCE LEARNING; COGNITION; COGNITIVE DYSFUNCTION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MAZE LEARNING; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PHOSPHODIESTERASE 4 INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; SIGNAL TRANSDUCTION; THIOREDOXINS; UP-REGULATION;

EID: 84975744239     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-016-9814-1     Document Type: Article

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