Neuroprotective effects of α-iso-cubebene against glutamate-induced damage in the HT22 hippocampal neuronal cell line

International Journal of Molecular Medicine

Volumn 35, Issue 2, 2015, Pages 525-532

  Park, Sun Young ^a   Jung, Won Jung ^a   Kang, Jum Soon ^a   Kim, Cheol Min ^b   Park, Geuntae ^a   Choi, Young Whan ^a  

^a Pusan National University   (South Korea)

^b Research Center for Anti Aging Technology Development   (South Korea)

Author keywords

Apoptosis; CAMP responsive element binding protein; Glutamate; Neuroprotection; Nrf2; iso cubebene

Indexed keywords

ALPHA ISO CUBEBENE; APOPTOSIS INDUCING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMIC ACID; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ALPHA-ISO-CUBEBENE; NERVE PROTEIN; SESQUITERPENE;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE SILENCING; HIPPOCAMPUS; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG EFFECTS; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY;

ANIMALS; CELL LINE; GLUTAMIC ACID; HIPPOCAMPUS; MICE; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84919701760     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.2031     Document Type: Article

References (32)

1. Coyle JT and Puttfarcken P: Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695, 1993.
2. Tan S, Sagara Y, Liu Y, Maher P and Schubert D: The regulation of reactive oxygen species production during programmed cell death. J Cell Biol 141: 1423-1432, 1998.
3. Elphick LM, Hawat M, Toms NJ, Meinander A, Mikhailov A, Eriksson JE and Kass GE: Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity. Toxicol Appl Pharmacol 232: 258-267, 2008.
4. Murphy TH, Miyamoto M, Sastre A, Schnaar RL and Coyle JT: Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2: 1547-1558, 1989.
5. Behl C, Lezoualc'h F, Trapp T, Widmann M, Skutella T and Holsboer F: Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology 138: 101-106, 1997.
6. Maher P and Schubert D: Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci 57: 1287-1305, 2000.
7. Stanciu M, Wang Y, Kentor R, et al: Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 275: 12200-12206, 2000.
8. Ravassard P, Pachoud B, Comte JC, et al: Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus. Sleep 32: 227-240, 2009.
9. Kumamaru E, Numakawa T, Adachi N, et al: Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 22: 546-558, 2008.
10. Fukui M, Song JH, Choi J, Choi HJ and Zhu BT: Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur J Pharmacol 617: 1-11, 2009.
11. Choi DW: Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci 11: 465-469, 1988.
12. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA and Nicotera P: Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973, 1995.
13. Gunter TE and Pfeiffer DR: Mechanisms by which mitochondria transport calcium. Am J Physiol 258: C755-C786, 1990.
14. Zhang Y and Bhavnani BR: Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci 7: 49, 2006.
15. Calkins MJ, Johnson DA, Townsend JA, et al: The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 11: 497-508, 2009.
16. van Muiswinkel FL and Kuiperij HB: The Nrf2-ARE signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders. Curr Drug Targets CNS Neurol Disord 4: 267-281, 2005.
17. Satoh T, McKercher SR and Lipton SA: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med 65: 645-657, 2013.
18. Lee J, Kim CH, Simon DK, et al: Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem 280: 40398-40401, 2005.
19. Baxter PS, Martel MA, McMahon A, Kind PC and Hardingham GE: Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1. J Neurochem 118: 365-378, 2011.
20. Park SY, Kim JH, Lee SJ and Kim Y: Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells. Toxicol Appl Pharmacol 268: 68-78, 2013.
21. Choi YW, Kim HJ, Park SS, et al: Inhibition of endothelial cell adhesion by the new anti-inflammatory agent alpha-iso-cubebene. Vascul Pharmacol 51: 215-224, 2009.
22. Lee SK, Kim SD, Lee HY, et al: α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis. Biochem Biophys Res Commun 426: 226-231, 2012.
23. Lee YJ, Shim JW, Lee YJ, et al: Identification of a novel compound that stimulates intracellular calcium increase and CXCL8 production in human neutrophils from Schisandra chinensis. Biochem Biophys Res Commun 379: 928-932, 2009.
24. Park SY, Park SJ, Park NJ, Joo WH, Lee SJ and Choi YW: α-Iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation. Neurosci Lett 555: 143-148, 2013.
25. Maher P and Davis JB: The role of monoamine metabolism in oxidative glutamate toxicity. J Neurosci 16: 6394-6401, 1996.
26. Ziady AG, Sokolow A, Shank S, Corey D, et al: Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 302: L1221-L1231, 2012.
27. Wang T, Gu J, Wu PF, et al: Protection by tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med 47: 229-240, 2009.
28. Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A and Yamamoto M: Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6: 857-868, 2001.
29. Arundine M and Tymianski M: Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 61: 657-668, 2004.
30. Tofighi R, Johansson C, Goldoni M, Ibrahim WN, Gogvadze V, Mutti A and Ceccatelli S: Hippocampal neurons exposed to the environmental contaminants methylmercury and polychlorinated biphenyls undergo cell death via parallel activation of calpains and lysosomal proteases. Neurotox Res 19: 183-194, 2011.
31. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE and Forman HJ: Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med 52: 2038-2046, 2012.
32. Wang H, Guo Z, Wu F, et al: PKA-mediated protein phosphorylation protects ezrin from calpain I cleavage. Biochem Biophys Res Commun 333: 496-501, 2005.