Human xenobiotic nuclear receptor PXR augments mycobacterium tuberculosis survival

Journal of Immunology

Volumn 197, Issue 1, 2016, Pages 244-255

  Bhagyaraj, Ella ^a   Nanduri, Ravikanth ^a   Saini, Ankita ^a   Dkhar, Hedwin Kitdorlang ^a   Ahuja, Nancy ^a   Chandra, Vemika ^a   Mahajan, Sahil ^a   Kalra, Rashi ^a   Tiwari, Drishti ^a   Sharma, Charu ^a   Janmeja, Ashok Kumar ^b   Gupta, Pawan ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b GOVERNMENT MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; MYCOLIC ACID; PREGNANE X RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; STEROID RECEPTOR; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR BACTERIUM; LIGAND BINDING; LIGAND BINDING DOMAIN; MACROPHAGE; MALE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOLYSOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSCRIPTION INITIATION; TUBERCULOSIS; ANIMAL; C57BL MOUSE; CELL LINE; CELL SURVIVAL; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHAGOSOME; TRANSGENE;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; HUMANS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; RECEPTORS, STEROID; TRANSGENES; TUBERCULOSIS; XENOBIOTICS;

EID: 84975295536     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1600203     Document Type: Article

References (43)

1. Szabova, L., D. Macejova, M. Dvorcakova, S. Mostbock, S. Blazickova, S. Zorad, S. Walrand, N. Cardinault, M. P. Vasson, E. Rock, and J. Brtko. 2003. Expression of nuclear retinoic acid receptor in peripheral blood mononuclear cells (PBMC) of healthy subjects. Life Sci. 72: 831-836.
2. Qiao, E., M. Ji, J. Wu, R. Ma, X. Zhang, Y. He, Q. Zha, X. Song, L. W. Zhu, and J. Tang. 2013. Expression of the PXR gene in various types of cancer and drug resistance. Oncol. Lett. 5: 1093-1100.
3. Matic, M., A. Mahns, M. Tsoli, A. Corradin, P. Polly, and G. R. Robertson. 2007. Pregnane X receptor: promiscuous regulator of detoxification pathways. Int. J. Biochem. Cell Biol. 39: 478-483.
4. Bhalla, S., C. Ozalp, S. Fang, L. Xiang, and J. K. Kemper. 2004. Ligandactivated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha: functional implications in hepatic cholesterol and glucose metabolism. J. Biol. Chem. 279: 45139-45147.
5. Sui, Y., J. Xu, J. Rios-Pilier, and C. Zhou. 2011. Deficiency of PXR decreases atherosclerosis in apoE-deficient mice. J. Lipid Res. 52: 1652-1659.
6. Dubrac, S., A. Elentner, S. Ebner, J. Horejs-Hoeck, and M. Schmuth. 2010. Modulation of T lymphocyte function by the pregnane X receptor. J. Immunol. 184: 2949-2957.
7. Swales, K. E., R. Moore, N. J. Truss, A. Tucker, T. D. Warner, M. Negishi, and D. Bishop-Bailey. 2012. Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. Cardiovasc. Res. 93: 674-681.
8. Wang, X., X. Fang, J. Zhou, Z. Chen, B. Zhao, L. Xiao, A. Liu, Y. S. Li, J. Y. Shyy, Y. Guan, et al. 2013. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proc. Natl. Acad. Sci. USA 110: 13174-13179.
9. Corbett, E. L., C. J.Watt, N.Walker, D. Maher, B. G.Williams, M. C. Raviglione, and C. Dye. 2003. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch. Intern. Med. 163: 1009-1021.
10. World Health Organization. 2015. Global Tuberculosis Control. World Health Organization, Geneva, Switzerland.
11. Jayachandran, R., N. Scherr, and J. Pieters. 2012. Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms. Expert Rev. Anti Infect. Ther. 10: 1007-1022.
12. Jayaswal, S., M. A. Kamal, R. Dua, S. Gupta, T. Majumdar, G. Das, D. Kumar, and K. V. Rao. 2010. Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathog. 6: e1000839.
13. Thornbrough, J. M., T. Hundley, R. Valdivia, and M. J. Worley. 2012. Human genome-wide RNAi screen for host factors that modulate intracellular Salmonella growth. PLoS One 7: e38097.
14. Tomioka, H. 2012. [Prospects for the development of new antituberculous drugs based on the drug targets related to virulence factors interfering with host cytokine networks]. Kansenshogaku Zasshi 86: 715-722.
15. Wu, K., J. Koo, X. Jiang, R. Chen, S. N. Cohen, and C. Nathan. 2012. Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. PLoS One 7: e30512.
16. Brightbill, H. D., D. H. Libraty, S. R. Krutzik, R. B. Yang, J. T. Belisle, J. R. Bleharski, M. Maitland, M. V. Norgard, S. E. Plevy, S. T. Smale, et al. 1999. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285: 732-736.
17. Kim, D.-K., J.-H. Jeong, J.-M. Lee, K. S. Kim, S.-H. Park, Y. D. Kim, M. Koh, M. Shin, Y. S. Jung, H.-S. Kim, et al. 2014. Inverse agonist of estrogen-related receptor g controls Salmonella typhimurium infection by modulating host iron homeostasis. Nat. Med. 20: 419-424.
18. Chandra, V., S. Mahajan, A. Saini, H. K. Dkhar, R. Nanduri, E. B. Raj, A. Kumar, and P. Gupta. 2013. Human IL10 gene repression by Rev-erba ameliorates Mycobacterium tuberculosis clearance. J. Biol. Chem. 288: 10692-10702.
19. Mahajan, S., H. K. Dkhar, V. Chandra, S. Dave, R. Nanduri, A. K. Janmeja, J. N. Agrewala, and P. Gupta. 2012. Mycobacterium tuberculosis modulates macrophage lipid-sensing nuclear receptors PPARg and TR4 for survival. J. Immunol. 188: 5593-5603.
20. Chandra, V., E. Bhagyaraj, R. Nanduri, N. Ahuja, and P. Gupta. 2015. NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy. Autophagy 11: 1987-1997.
21. Dkhar, H. K., R. Nanduri, S. Mahajan, S. Dave, A. Saini, A. K. Somavarapu, A. Arora, R. Parkesh, K. G. Thakur, S. Mayilraj, and P. Gupta. 2014. Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: A case of a heterologous and noncanonical ligand-receptor pair. J. Immunol. 193: 295-305.
22. Barish, G. D., M. Downes, W. A. Alaynick, R. T. Yu, C. B. Ocampo, A. L. Bookout, D. J. Mangelsdorf, and R. M. Evans. 2005. A nuclear receptor atlas: macrophage activation. Mol. Endocrinol. 19: 2466-2477.
23. Delfosse, V., B. Dendele, T. Huet, M. Grimaldi, A. Boulahtouf, S. Gerbal-Chaloin, B. Beucher, D. Roecklin, C. Muller, R. Rahmani, et al. 2015. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat. Commun. 6: 8089.
24. Nanduri, R., S. Mahajan, E. Bhagyaraj, K. Sethi, R. Kalra, V. Chandra, and P. Gupta. 2015. The active form of vitamin D transcriptionally represses Smad7 signaling and activates extracellular signal-regulated kinase (ERK) to inhibit the differentiation of an inflammatory T helper cell subset and suppress experimental autoimmune encephalomyelitis. J. Biol. Chem. 290: 12222-12236.
25. Mahajan, S., A. Saini, V. Chandra, R. Nanduri, R. Kalra, E. Bhagyaraj, N. Khatri, and P. Gupta. 2015. Nuclear receptor Nr4a2 promotes alternative polarization of macrophages and confers protection in sepsis. J. Biol. Chem. 290: 18304-18314.
26. Trott, O., and A. J. Olson. 2010. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 31: 455-461.
27. Russell, D. G., P.-J. Cardona, M.-J. Kim, S. Allain, and F. Altare. 2009. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat. Immunol. 10: 943-948.
28. Zhou, C., N. King, K. Y. Chen, and J. L. Breslow. 2009. Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice. J. Lipid Res. 50: 2004-2013.
29. Briken, V., and J. L. Miller. 2008. Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis. Future Microbiol. 3: 415-422.
30. Wang, K., I. Damjanov, and Y.-J. Y. Wan. 2010. The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. Lab. Invest. 90: 257-265.
31. Zhou, J., M. Liu, Y. Zhai, and W. Xie. 2008. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol. Endocrinol. 22: 868-880.
32. Zhang, J., R. Jiang, H. Takayama, and Y. Tanaka. 2005. Survival of virulent Mycobacterium tuberculosis involves preventing apoptosis induced by Bcl-2 upregulation and release resulting from necrosis in J774 macrophages. Microbiol. Immunol. 49: 845-852.
33. Cooper, A. M., K. D. Mayer-Barber, and A. Sher. 2011. Role of innate cytokines in mycobacterial infection. Mucosal Immunol. 4: 252-260.
34. Giacomini, E., E. Iona, L. Ferroni, M. Miettinen, L. Fattorini, G. Orefici, I. Julkunen, and E. M. Coccia. 2001. Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response. J. Immunol. 166: 7033-7041.
35. van Crevel, R., T. H. M. Ottenhoff, and J. W. M. van der Meer. 2002. Innate immunity to Mycobacterium tuberculosis. Clin. Microbiol. Rev. 15: 294-309.
36. Dietzold, J., A. Gopalakrishnan, and P. Salgame. 2015. Duality of lipid mediators in host response against Mycobacterium tuberculosis: good cop, bad cop. F1000Prime Rep. 7: 29.
37. Chen, M., M. Divangahi, H. Gan, D. S. J. Shin, S. Hong, D. M. Lee, C. N. Serhan, S. M. Behar, and H. G. Remold. 2008. Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J. Exp. Med. 205: 2791-2801.
38. Zhang, Y., and W. W. Yew. 2009. Mechanisms of drug resistance in Mycobacterium tuberculosis. Int. J. Tuberc. Lung Dis. 13: 1320-1330.
39. Behar, S. M., C. J. Martin, M. G. Booty, T. Nishimura, X. Zhao, H.-X. Gan, M. Divangahi, and H. G. Remold. 2011. Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol. 4: 279-287.
40. Harris, J., and J. Keane. 2010. How tumour necrosis factor blockers interfere with tuberculosis immunity. Clin. Exp. Immunol. 161: 1-9.
41. Forrellad, M. A., L. I. Klepp, A. Gioffré, J. Sabio y García, H. R. Morbidoni, M. de la Paz Santangelo, A. A. Cataldi, and F. Bigi. 2013. Virulence factors of the Mycobacterium tuberculosis complex. Virulence 4: 3-66.
42. Rhoades, E., F. Hsu, J. B. Torrelles, J. Turk, D. Chatterjee, and D. G. Russell. 2003. Identification and macrophage-activating activity of glycolipids released from intracellular Mycobacterium bovis BCG. Mol. Microbiol. 48: 875-888.
43. Peyron, P., J. Vaubourgeix, Y. Poquet, F. Levillain, C. Botanch, F. Bardou, M. Daffé, J.-F. Emile, B. Marchou, P.-J. Cardona, et al. 2008. Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS Pathog. 4: e1000204.