Shear stress activation of nuclear receptor PXR in endothelial detoxification

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 32, 2013, Pages 13174-13179

  Wang, Xiaohong ^a,b   Fang, Xi ^a   Zhou, Jing ^b   Chen, Zhen ^b   Zhao, Beilei ^a   Xiao, Lei ^c   Liu, Ao ^a   Li, Yi Shuan J ^b   Shyy, John Y J ^b,c   Guan, Youfei ^a   Chien, Shu ^b   Wang, Nanping ^a,c  

^a Peking University   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Endothelial homeostasis; Gene regulation; Hemodynamics; Nuclear hormone receptor

Indexed keywords

CASPASE 3; CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA ARCH; APOPTOSIS; ARTICLE; CAROTID ARTERY; CELL PROTECTION; CONTROLLED STUDY; DETOXIFICATION; DNA MICROARRAY; GENE EXPRESSION; GENE OVEREXPRESSION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; SHEAR STRESS; THORACIC AORTA;

ENDOTHELIAL HOMEOSTASIS; GENE REGULATION; HEMODYNAMICS; NUCLEAR HORMONE RECEPTOR;

ANIMALS; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CAROTID ARTERIES; CELL LINE, TUMOR; CELLS, CULTURED; GENE EXPRESSION PROFILING; GLUTATHIONE TRANSFERASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STRESS, MECHANICAL; XENOBIOTICS;

EID: 84881472474     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312065110     Document Type: Article

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