The active form of vitamin D transcriptionally represses Smad7 signaling and activates extracellular signal-regulated kinase (ERK) to inhibit the differentiation of a inflammatory T helper cell subset and suppress experimental autoimmune encephalomyelitis

Journal of Biological Chemistry

Volumn 290, Issue 19, 2015, Pages 12222-12236

  Nanduri, Ravikanth ^a   Mahajan, Sahil ^a   Bhagyaraj, Ella ^a   Sethi, Kanupriya ^a   Kalra, Rashi ^a   Chandra, Vemika ^a   Gupta, Pawan ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; ENZYME ACTIVITY; GENES; T-CELLS; VITAMINS;

1 ,25-DIHYDROXYVITAMIN D3; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXTRACELLULAR SIGNAL-REGULATED KINASE; GENE REPRESSION; RESPONSE ELEMENTS; SMAD SIGNALING; SPECIFIC BINDING; VITAMIN D RECEPTOR;

CELL SIGNALING;

CALCITRIOL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 22; INTERLEUKIN 23 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; SMAD3 PROTEIN; SMAD7 PROTEIN; VITAMIN D RECEPTOR; DIHYDROXY-VITAMIN D3; SMAD7 PROTEIN, MOUSE; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; HELPER CELL; IL17A GENE; IL17F GENE; IL22 GENE; IL23R GENE; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMAD3 GENE; SMAD7 GENE; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION REGULATION; VITAMIN D RESPONSIVE ELEMENT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C3H MOUSE; C57BL MOUSE; CELL DIFFERENTIATION; CELL NUCLEUS; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; CYTOLOGY; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENETIC TRANSCRIPTION; LYMPH NODE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TH17 CELL;

ANIMALS; CELL DIFFERENTIATION; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON-GAMMA; LYMPH NODES; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; SMAD7 PROTEIN; T-LYMPHOCYTES, HELPER-INDUCER; TH17 CELLS; TRANSCRIPTION, GENETIC; VITAMIN D;

EID: 84929224375     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.621839     Document Type: Article

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