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Volumn 13, Issue 9, 2016, Pages 508-516

Understanding the mechanisms of faecal microbiota transplantation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIOCIN; COLESTIPOL; COLESTYRAMINE; INTERLEUKIN 1; INTERLEUKIN 22; INTERLEUKIN 23; LANTIBIOTIC; MEVINOLIN; OBETICHOLIC ACID; URSODEOXYCHOLIC ACID; VANCOMYCIN; BILE ACID;

EID: 84975292883     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2016.98     Document Type: Review
Times cited : (377)

References (107)
  • 1
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach, M. A. & Walsh, C. T. Antibiotics for emerging pathogens. Science 325, 1089-1093 (2009).
    • (2009) Science , vol.325 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 2
    • 84887627398 scopus 로고    scopus 로고
    • Antibiotic resistance-The need for global solutions
    • Laxminarayan, R. et al. Antibiotic resistance-the need for global solutions. Lancet Infect. Dis. 13, 1057-1098 (2013).
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 1057-1098
    • Laxminarayan, R.1
  • 3
    • 55249105923 scopus 로고    scopus 로고
    • Clostridium difficile-more difficult than ever
    • Kelly, C. P. & LaMont, J. T. Clostridium difficile-more difficult than ever. N. Engl. J. Med. 359, 1932-1940 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1932-1940
    • Kelly, C.P.1    LaMont, J.T.2
  • 4
    • 84923775846 scopus 로고    scopus 로고
    • Burden of Clostridium difficile infection in the United States
    • Lessa, F. C. et al. Burden of Clostridium difficile infection in the United States. N. Engl. J. Med. 372, 825-834 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 825-834
    • Lessa, F.C.1
  • 5
    • 84856969539 scopus 로고    scopus 로고
    • Fecal microbiota transplantation and emerging applications
    • Borody, T. J. & Khoruts, A. Fecal microbiota transplantation and emerging applications. Nat. Rev. Gastroenterol. Hepatol. 9, 88-96 (2012).
    • (2012) Nat. Rev. Gastroenterol. Hepatol. , vol.9 , pp. 88-96
    • Borody, T.J.1    Khoruts, A.2
  • 6
    • 0036311186 scopus 로고    scopus 로고
    • Breaking the cycle: Treatment strategies for 163 cases of recurrent Clostridium difficile disease
    • McFarland, L. V., Elmer, G. W. & Surawicz, C. M. Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am. J. Gastroenterol. 97, 1769-1775 (2002).
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 1769-1775
    • McFarland, L.V.1    Elmer, G.W.2    Surawicz, C.M.3
  • 7
    • 77951700268 scopus 로고    scopus 로고
    • Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea
    • Khoruts, A., Dicksved, J., Jansson, J. K. & Sadowsky, M. J. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J. Clin. Gastroenterol. 44, 354-360 (2010).
    • (2010) J. Clin. Gastroenterol. , vol.44 , pp. 354-360
    • Khoruts, A.1    Dicksved, J.2    Jansson, J.K.3    Sadowsky, M.J.4
  • 8
    • 84874737205 scopus 로고    scopus 로고
    • High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria
    • Hamilton, M. J., Weingarden, A. R., Unno, T., Khoruts, A. & Sadowsky, M. J. High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes 4, 125-135 (2013).
    • (2013) Gut Microbes , vol.4 , pp. 125-135
    • Hamilton, M.J.1    Weingarden, A.R.2    Unno, T.3    Khoruts, A.4    Sadowsky, M.J.5
  • 9
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • van Nood, E. et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407-415 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 407-415
    • Van Nood, E.1
  • 10
    • 84924533173 scopus 로고    scopus 로고
    • Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation
    • Shankar, V. et al. Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation. Microbiome 2, 13 (2014).
    • (2014) Microbiome , vol.2 , pp. 13
    • Shankar, V.1
  • 11
    • 84903954202 scopus 로고    scopus 로고
    • Recovery of the gut microbiome following fecal microbiota transplantation
    • Seekatz, A. M. et al. Recovery of the gut microbiome following fecal microbiota transplantation. mBio 5, e00893-e00814 (2014).
    • (2014) MBio , vol.5 , pp. e00814-e00893
    • Seekatz, A.M.1
  • 12
    • 84931355745 scopus 로고    scopus 로고
    • Dynamic changes in short-and long-term bacterial composition following fecal microbiota transplantation for recurrent Clostridium difficile infection
    • Weingarden, A. et al. Dynamic changes in short-and long-term bacterial composition following fecal microbiota transplantation for recurrent Clostridium difficile infection. Microbiome 3, 10 (2015).
    • (2015) Microbiome , vol.3 , pp. 10
    • Weingarden, A.1
  • 13
    • 84894105226 scopus 로고    scopus 로고
    • Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection
    • Weingarden, A. R. et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am. J. Physiol. Gastrointest. Liver Physiol. 306, G310-G319 (2014).
    • (2014) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.306 , pp. G310-G319
    • Weingarden, A.R.1
  • 14
    • 84928885767 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for Clostridium difficile infection: A systematic review
    • Drekonja, D. et al. Fecal microbiota transplantation for Clostridium difficile infection: a systematic review. Ann. Intern. Med. 162, 630-638 (2015).
    • (2015) Ann. Intern. Med. , vol.162 , pp. 630-638
    • Drekonja, D.1
  • 15
    • 84883242095 scopus 로고    scopus 로고
    • Resolution of severe Clostridium difficile infection following sequential fecal microbiota transplantation
    • Weingarden, A. R., Hamilton, M. J., Sadowsky, M. J. & Khoruts, A. Resolution of severe Clostridium difficile infection following sequential fecal microbiota transplantation. J. Clin. Gastroenterol. 47, 735-737 (2013).
    • (2013) J. Clin. Gastroenterol. , vol.47 , pp. 735-737
    • Weingarden, A.R.1    Hamilton, M.J.2    Sadowsky, M.J.3    Khoruts, A.4
  • 16
    • 85006428014 scopus 로고    scopus 로고
    • Faecal microbiota transplantation plus selected use of vancomycin for severe-complicated Clostridium difficile infection: Description of a protocol with high success rate
    • Fischer, M. et al. Faecal microbiota transplantation plus selected use of vancomycin for severe-complicated Clostridium difficile infection: description of a protocol with high success rate. Aliment. Pharmacol. Ther. 42, 470-476 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 470-476
    • Fischer, M.1
  • 17
    • 80052074327 scopus 로고    scopus 로고
    • Predictors of fatal outcome after colectomy for fulminant Clostridium difficile Colitis: A 10-year experience
    • dr. markelov@ gmail. Com
    • Markelov, A., Livert, D. & Kohli, H. Predictors of fatal outcome after colectomy for fulminant Clostridium difficile Colitis: a 10-year experience. dr. markelov@ gmail. com. Am. Surg. 77, 977-980 (2011).
    • (2011) Am. Surg. , vol.77 , pp. 977-980
    • Markelov, A.1    Livert, D.2    Kohli, H.3
  • 18
    • 33846436449 scopus 로고    scopus 로고
    • Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain
    • Lamontagne, F. et al. Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain. Ann. Surg. 245, 267-272 (2007).
    • (2007) Ann. Surg. , vol.245 , pp. 267-272
    • Lamontagne, F.1
  • 19
    • 84862309942 scopus 로고    scopus 로고
    • Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection
    • Hamilton, M. J., Weingarden, A. R., Sadowsky, M. J. & Khoruts, A. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am. J. Gastroenterol. 107, 761-767 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 761-767
    • Hamilton, M.J.1    Weingarden, A.R.2    Sadowsky, M.J.3    Khoruts, A.4
  • 20
    • 84908681868 scopus 로고    scopus 로고
    • Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
    • Youngster, I. et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312, 1772-1778 (2014).
    • (2014) JAMA , vol.312 , pp. 1772-1778
    • Youngster, I.1
  • 21
    • 39349107697 scopus 로고    scopus 로고
    • Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea
    • Chang, J. Y. et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J. Infect. Dis. 197, 435-438 (2008).
    • (2008) J. Infect. Dis. , vol.197 , pp. 435-438
    • Chang, J.Y.1
  • 22
    • 84978908932 scopus 로고    scopus 로고
    • Long-term changes of bacterial and viral compositions in the intestine of a recovered Clostridium difficile patient after fecal microbiota transplantation
    • Broecker, F. et al. Long-term changes of bacterial and viral compositions in the intestine of a recovered Clostridium difficile patient after fecal microbiota transplantation. Cold Spring Harb. Mol. Case Stud. 2, a000448 (2016).
    • (2016) Cold Spring Harb. Mol. Case Stud. , vol.2 , pp. 000448
    • Broecker, F.1
  • 23
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: Current status and the future ahead
    • Kostic, A. D., Xavier, R. J. & Gevers, D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146, 1489-1499 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 24
    • 84885479748 scopus 로고    scopus 로고
    • Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation
    • Angelberger, S. et al. Temporal bacterial community dynamics vary among ulcerative colitis patients after fecal microbiota transplantation. Am. J. Gastroenterol. 108, 1620-1630 (2013).
    • (2013) Am. J. Gastroenterol. , vol.108 , pp. 1620-1630
    • Angelberger, S.1
  • 25
    • 84884585915 scopus 로고    scopus 로고
    • Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis
    • Kump, P. K. et al. Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis. Inflamm. Bowel Dis. 19, 2155-2165 (2013).
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 2155-2165
    • Kump, P.K.1
  • 26
    • 84931423571 scopus 로고    scopus 로고
    • Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis
    • Rossen, N. G. et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 149, 110-1184 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 110-1184
    • Rossen, N.G.1
  • 27
    • 84931469899 scopus 로고    scopus 로고
    • Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial
    • e6
    • Moayyedi, P. et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149, 102-109. e6 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 102-109
    • Moayyedi, P.1
  • 28
    • 84930760898 scopus 로고    scopus 로고
    • Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation
    • Kolho, K. L. et al. Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation. Am. J. Gastroenterol. 110, 921-930 (2015).
    • (2015) Am. J. Gastroenterol. , vol.110 , pp. 921-930
    • Kolho, K.L.1
  • 29
    • 84981240884 scopus 로고    scopus 로고
    • Anti-tumour necrosis factor treatment with adalimumab induces changes in the microbiota of Crohn's disease
    • Busquets, D. et al. Anti-tumour necrosis factor treatment with adalimumab induces changes in the microbiota of Crohn's disease. J. Crohns Colitis 9, 899-906 (2015).
    • (2015) J. Crohns Colitis , vol.9 , pp. 899-906
    • Busquets, D.1
  • 30
    • 84942673401 scopus 로고    scopus 로고
    • Low level engraftment and improvement following a single colonoscopic administration of fecal microbiota to patients with ulcerative colitis
    • Damman, C. J. et al. Low level engraftment and improvement following a single colonoscopic administration of fecal microbiota to patients with ulcerative colitis. PLoS ONE 10, e0133925 (2015).
    • (2015) PLoS ONE , vol.10 , pp. 0133925
    • Damman, C.J.1
  • 32
    • 84905027614 scopus 로고    scopus 로고
    • Reset of a critically disturbed microbial ecosystem: Faecal transplant in recurrent Clostridium difficile infection
    • Fuentes, S. et al. Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection. ISME J. 8, 1621-1633 (2014).
    • (2014) ISME J. , vol.8 , pp. 1621-1633
    • Fuentes, S.1
  • 33
    • 84965075945 scopus 로고    scopus 로고
    • Transfer of viral communities between human individuals during fecal microbiota transplantation
    • Chehoud, C. et al. Transfer of viral communities between human individuals during fecal microbiota transplantation. mBio 7, e00322-e00316 (2016).
    • (2016) MBio , vol.7 , pp. e00316-e00322
    • Chehoud, C.1
  • 34
    • 70450227218 scopus 로고    scopus 로고
    • The fascination with probiotics for Clostridium difficile infection: Lack of evidence for prophylactic or therapeutic efficacy
    • Miller, M. The fascination with probiotics for Clostridium difficile infection: lack of evidence for prophylactic or therapeutic efficacy. Anaerobe 15, 281-284 (2009).
    • (2009) Anaerobe , vol.15 , pp. 281-284
    • Miller, M.1
  • 35
    • 84877020842 scopus 로고    scopus 로고
    • Stool substitute transplant therapy for the eradication of Clostridium difficile infection: RePOOPulating the gut
    • Petrof, E. O. et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut. Microbiome 1, 3 (2013).
    • (2013) Microbiome , vol.1 , pp. 3
    • Petrof, E.O.1
  • 36
    • 65449155189 scopus 로고    scopus 로고
    • Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain
    • O'Connor, J. R., Johnson, S. & Gerding, D. N. Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology 136, 1913-1924 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1913-1924
    • O'Connor, J.R.1    Johnson, S.2    Gerding, D.N.3
  • 37
    • 84863676446 scopus 로고    scopus 로고
    • Current status of Clostridium difficile infection epidemiology
    • Lessa, F. C., Gould, C. V. & McDonald, L. C. Current status of Clostridium difficile infection epidemiology. Clin. Infect. Dis. 55, S65-S70 (2012).
    • (2012) Clin. Infect. Dis. , vol.55 , pp. S65-S70
    • Lessa, F.C.1    Gould, C.V.2    McDonald, L.C.3
  • 38
    • 84961288867 scopus 로고    scopus 로고
    • Are we really vastly outnumbered Revisiting the ratio of bacterial to host cells in humans
    • Sender, R., Fuchs, S. & Milo, R. Are we really vastly outnumbered Revisiting the ratio of bacterial to host cells in humans. Cell 164, 337-340 (2016).
    • (2016) Cell , vol.164 , pp. 337-340
    • Sender, R.1    Fuchs, S.2    Milo, R.3
  • 39
    • 84885573828 scopus 로고    scopus 로고
    • Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
    • Ng, K. M. et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature 502, 96-99 (2013).
    • (2013) Nature , vol.502 , pp. 96-99
    • Ng, K.M.1
  • 40
    • 0023751801 scopus 로고
    • Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora
    • Wilson, K. H. & Perini, F. Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora. Infect. Immun. 56, 2610-2614 (1988).
    • (1988) Infect. Immun. , vol.56 , pp. 2610-2614
    • Wilson, K.H.1    Perini, F.2
  • 41
    • 84876573682 scopus 로고    scopus 로고
    • Clostridium difficile is an autotrophic bacterial pathogen
    • Kopke, M., Straub, M. & Durre, P. Clostridium difficile is an autotrophic bacterial pathogen. PLoS ONE 8, e62157 (2013).
    • (2013) PLoS ONE , vol.8 , pp. 62157
    • Kopke, M.1    Straub, M.2    Durre, P.3
  • 42
    • 84929148131 scopus 로고    scopus 로고
    • Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C. Difficile infection: A randomized clinical trial
    • Gerding, D. N. et al. Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C. difficile infection: a randomized clinical trial. JAMA 313, 1719-1727 (2015).
    • (2015) JAMA , vol.313 , pp. 1719-1727
    • Gerding, D.N.1
  • 43
    • 84868158515 scopus 로고    scopus 로고
    • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
    • Lawley, T. D. et al. Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog. 8, e1002995 (2012).
    • (2012) PLoS Pathog , vol.8 , pp. 1002995
    • Lawley, T.D.1
  • 44
    • 0037154251 scopus 로고    scopus 로고
    • Chemical warfare from an ecological perspective
    • Lenski, R. E. & Riley, M. A. Chemical warfare from an ecological perspective. Proc. Natl Acad. Sci. USA 99, 556-558 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 556-558
    • Lenski, R.E.1    Riley, M.A.2
  • 45
    • 77952679997 scopus 로고    scopus 로고
    • Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile
    • Rea, M. C. et al. Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc. Natl Acad. Sci. USA 107, 9352-9357 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 9352-9357
    • Rea, M.C.1
  • 46
    • 0032693081 scopus 로고    scopus 로고
    • The lantibiotic nisin, a special case or not Biochim
    • Breukink, E. & de Kruijff, B. The lantibiotic nisin, a special case or not Biochim. Biophys. Acta 1462, 223-234 (1999).
    • (1999) Biophys. Acta , vol.1462 , pp. 223-234
    • Breukink, E.1    De Kruijff, B.2
  • 47
    • 84959307431 scopus 로고    scopus 로고
    • Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination
    • Le Lay, C., Dridi, L., Bergeron, M. G., Ouellette, M. & Fliss, I. Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination. J. Med. Microbiol. 65, 169-175 (2016).
    • (2016) J. Med. Microbiol. , vol.65 , pp. 169-175
    • Le Lay, C.1    Dridi, L.2    Bergeron, M.G.3    Ouellette, M.4    Fliss, I.5
  • 48
    • 84874215729 scopus 로고    scopus 로고
    • Prevalence and characterization of Clostridium perfringens from the faecal microbiota of elderly Irish subjects
    • Lakshminarayanan, B. et al. Prevalence and characterization of Clostridium perfringens from the faecal microbiota of elderly Irish subjects. J. Med. Microbiol. 62, 457-466 (2013).
    • (2013) J. Med. Microbiol. , vol.62 , pp. 457-466
    • Lakshminarayanan, B.1
  • 49
    • 0037113945 scopus 로고    scopus 로고
    • Preservation and fermentation: Past, present and future
    • Ross, R. P., Morgan, S. & Hill, C. Preservation and fermentation: past, present and future. Int. J. Food Microbiol. 79, 3-16 (2002).
    • (2002) Int. J. Food Microbiol. , vol.79 , pp. 3-16
    • Ross, R.P.1    Morgan, S.2    Hill, C.3
  • 50
    • 34447250021 scopus 로고    scopus 로고
    • Antimicrobial activity of lacticin 3, 147 against clinical Clostridium difficile strains
    • Rea, M. C. et al. Antimicrobial activity of lacticin 3, 147 against clinical Clostridium difficile strains. J. Med. Microbiol. 56, 940-946 (2007).
    • (2007) J. Med. Microbiol. , vol.56 , pp. 940-946
    • Rea, M.C.1
  • 51
    • 0031890703 scopus 로고    scopus 로고
    • Lacticin 3147, a broad-spectrum bacteriocin which selectively dissipates the membrane potential
    • McAuliffe, O. et al. Lacticin 3147, a broad-spectrum bacteriocin which selectively dissipates the membrane potential. Appl. Environ. Microbiol. 64, 439-445 (1998).
    • (1998) Appl. Environ. Microbiol. , vol.64 , pp. 439-445
    • McAuliffe, O.1
  • 52
    • 84907412918 scopus 로고    scopus 로고
    • Staggered and tapered antibiotic withdrawal with administration of kefir for recurrent Clostridium difficile infection
    • Bakken, J. S. Staggered and tapered antibiotic withdrawal with administration of kefir for recurrent Clostridium difficile infection. Clin. Infect. Dis. 59, 858-861 (2014).
    • (2014) Clin. Infect. Dis. , vol.59 , pp. 858-861
    • Bakken, J.S.1
  • 53
    • 77956871102 scopus 로고    scopus 로고
    • Clostridium difficile infection
    • Heinlen, L. & Ballard, J. D. Clostridium difficile infection. Am. J. Med. Sci. 340, 247-252 (2010).
    • (2010) Am. J. Med. Sci. , vol.340 , pp. 247-252
    • Heinlen, L.1    Ballard, J.D.2
  • 54
    • 0020554353 scopus 로고
    • Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination
    • Wilson, K. H. Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination. J. Clin. Microbiol. 18, 1017-1019 (1983).
    • (1983) J. Clin. Microbiol. , vol.18 , pp. 1017-1019
    • Wilson, K.H.1
  • 55
    • 84961150650 scopus 로고    scopus 로고
    • Reexamining the germination phenotypes of several Clostridium difficile strains suggests another role for the CspC germinant receptor
    • Bhattacharjee, D. et al. Reexamining the germination phenotypes of several Clostridium difficile strains suggests another role for the CspC germinant receptor. J. Bacteriol. 198, 777-786 (2015).
    • (2015) J. Bacteriol. , vol.198 , pp. 777-786
    • Bhattacharjee, D.1
  • 56
    • 84969704060 scopus 로고    scopus 로고
    • Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation
    • Browne, H. P. et al. Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation. Nature 533, 543-546 (2016).
    • (2016) Nature , vol.533 , pp. 543-546
    • Browne, H.P.1
  • 57
    • 84878518519 scopus 로고    scopus 로고
    • Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection
    • Francis, M. B., Allen, C. A., Shrestha, R. & Sorg, J. A. Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection. PLoS Pathog. 9, e1003356 (2013).
    • (2013) PLoS Pathog , vol.9 , pp. 1003356
    • Francis, M.B.1    Allen, C.A.2    Shrestha, R.3    Sorg, J.A.4
  • 58
    • 75149112859 scopus 로고    scopus 로고
    • SleC is essential for germination of Clostridium difficile spores in nutrient-rich medium supplemented with the bile salt taurocholate
    • Burns, D. A., Heap, J. T. & Minton, N. P. SleC is essential for germination of Clostridium difficile spores in nutrient-rich medium supplemented with the bile salt taurocholate. J. Bacteriol. 192, 657-664 (2010).
    • (2010) J. Bacteriol. , vol.192 , pp. 657-664
    • Burns, D.A.1    Heap, J.T.2    Minton, N.P.3
  • 59
    • 77957337708 scopus 로고    scopus 로고
    • Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid
    • Sorg, J. A. & Sonenshein, A. L. Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J. Bacteriol. 192, 4983-4990 (2010).
    • (2010) J. Bacteriol. , vol.192 , pp. 4983-4990
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 60
    • 50249180215 scopus 로고    scopus 로고
    • Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
    • Hofmann, A. F. & Hagey, L. R. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell. Mol. Life Sci. 65, 2461-2483 (2008).
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 2461-2483
    • Hofmann, A.F.1    Hagey, L.R.2
  • 61
    • 84958576368 scopus 로고    scopus 로고
    • Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control Clostridium difficile germination and growth
    • Weingarden, A. R. et al. Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control Clostridium difficile germination and growth. PLoS ONE 11, e0147210 (2016).
    • (2016) PLoS ONE , vol.11 , pp. 0147210
    • Weingarden, A.R.1
  • 62
    • 0018778842 scopus 로고
    • Colonic absorption of unconjugated bile acids: Perfusion studies in man
    • Mekhjian, H. S., Phillips, S. F. & Hofmann, A. F. Colonic absorption of unconjugated bile acids: perfusion studies in man. Dig. Dis. Sci. 24, 545-550 (1979).
    • (1979) Dig. Dis. Sci. , vol.24 , pp. 545-550
    • Mekhjian, H.S.1    Phillips, S.F.2    Hofmann, A.F.3
  • 63
    • 0018097454 scopus 로고
    • Sex differences in the size of bile acid pools
    • Bennion, L. J. et al. Sex differences in the size of bile acid pools. Metabolism 27, 961-969 (1978).
    • (1978) Metabolism , vol.27 , pp. 961-969
    • Bennion, L.J.1
  • 64
    • 84903818607 scopus 로고    scopus 로고
    • The outcome and long-term follow-up of 94 patients with recurrent and refractory Clostridium difficile infection using single to multiple fecal microbiota transplantation via retention enema
    • Lee, C. H. et al. The outcome and long-term follow-up of 94 patients with recurrent and refractory Clostridium difficile infection using single to multiple fecal microbiota transplantation via retention enema. Eur. J. Clin. Microbiol. Infect. Dis. 33, 1425-1428 (2014).
    • (2014) Eur. J. Clin. Microbiol. Infect. Dis. , vol.33 , pp. 1425-1428
    • Lee, C.H.1
  • 65
    • 84962934242 scopus 로고    scopus 로고
    • The long-term efficacy and safety of fecal microbiota transplant for recurrent, severe, and complicated Clostridium difficile infection in 146 elderly individuals
    • Agrawal, M. et al. The long-term efficacy and safety of fecal microbiota transplant for recurrent, severe, and complicated Clostridium difficile infection in 146 elderly individuals. J. Clin. Gastroenterol. 146, 542-S-43 (2015).
    • (2015) J. Clin. Gastroenterol. , vol.146 , pp. 542-543
    • Agrawal, M.1
  • 66
    • 84964765013 scopus 로고    scopus 로고
    • Inflammatory bowel disease affects the outcome of fecal microbiota transplantation for recurrent Clostridium difficile infection
    • Khoruts, A. et al. Inflammatory bowel disease affects the outcome of fecal microbiota transplantation for recurrent Clostridium difficile infection. Clin. Gastroenterol. Hepatol. http://dx. doi. org/10. 1016/j. cgh. 2016. 02. 018 (2016).
    • (2016) Clin. Gastroenterol. Hepatol.
    • Khoruts, A.1
  • 68
    • 77954426370 scopus 로고    scopus 로고
    • Asymptomatic colonization by Clostridium difficile in infants: Implications for disease in later life
    • Jangi, S. & Lamont, J. T. Asymptomatic colonization by Clostridium difficile in infants: implications for disease in later life. J. Pediatr. Gastroenterol. Nutr. 51, 2-7 (2010).
    • (2010) J. Pediatr. Gastroenterol. Nutr. , vol.51 , pp. 2-7
    • Jangi, S.1    Lamont, J.T.2
  • 69
    • 0017072355 scopus 로고
    • Clostridium difficile: Isolation and characteristics
    • Hafiz, S. & Oakley, C. L. Clostridium difficile: isolation and characteristics. J. Med. Microbiol. 9, 129-136 (1976).
    • (1976) J. Med. Microbiol. , vol.9 , pp. 129-136
    • Hafiz, S.1    Oakley, C.L.2
  • 70
    • 0034999642 scopus 로고    scopus 로고
    • Microbes and microbial toxins: Paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins
    • Pothoulakis, C. & Lamont, J. T. Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins. Am. J. Physiol. Gastrointest. Liver Physiol. 280, G178-G183 (2001).
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.280 , pp. G178-G183
    • Pothoulakis, C.1    Lamont, J.T.2
  • 71
    • 84905675648 scopus 로고    scopus 로고
    • Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
    • Hill, C. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506-514 (2014).
    • (2014) Nat. Rev. Gastroenterol. Hepatol. , vol.11 , pp. 506-514
    • Hill, C.1
  • 72
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie, C. G. et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517, 205-208 (2015).
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1
  • 73
    • 39749121022 scopus 로고    scopus 로고
    • Treatment of Clostridium difficile infection
    • Gerding, D. N., Muto, C. A. & Owens, R. C. Jr Treatment of Clostridium difficile infection. Clin. Infect. Dis. 46, S32-S42 (2008).
    • (2008) Clin. Infect. Dis. , vol.46 , pp. S32-S42
    • Gerding, D.N.1    Muto, C.A.2    Owens, R.C.3
  • 74
    • 0020040748 scopus 로고
    • Randomized controlled trial of colestipol in antibiotic-associated colitis
    • Mogg, G. A. et al. Randomized controlled trial of colestipol in antibiotic-associated colitis. Br. J. Surg. 69, 137-139 (1982).
    • (1982) Br. J. Surg. , vol.69 , pp. 137-139
    • Mogg, G.A.1
  • 75
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA)
    • Cohen, S. H. et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect. Control Hosp. Epidemiol. 31, 431-455 (2010).
    • (2010) Infect. Control Hosp. Epidemiol. , vol.31 , pp. 431-455
    • Cohen, S.H.1
  • 76
    • 0025747508 scopus 로고
    • Regulation of bile acid synthesis in humans: Effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7-hydroxylation rates in vivo
    • Bertolotti, M. et al. Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7-hydroxylation rates in vivo. Hepatology 14, 830-837 (1991).
    • (1991) Hepatology , vol.14 , pp. 830-837
    • Bertolotti, M.1
  • 77
    • 0025687290 scopus 로고
    • Regulation of hepatic cholesterol metabolism in humans: Stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients
    • Reihner, E. et al. Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients. J. Lipid Res. 31, 2219-2226 (1990).
    • (1990) J. Lipid Res. , vol.31 , pp. 2219-2226
    • Reihner, E.1
  • 78
    • 0141643397 scopus 로고    scopus 로고
    • Influence of newly synthesized cholesterol on bile acid synthesis during chronic inhibition of bile acid absorption
    • Bertolotti, M. et al. Influence of newly synthesized cholesterol on bile acid synthesis during chronic inhibition of bile acid absorption. Hepatology 38, 939-946 (2003).
    • (2003) Hepatology , vol.38 , pp. 939-946
    • Bertolotti, M.1
  • 79
    • 84915747794 scopus 로고    scopus 로고
    • The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid
    • Walters, J. R. et al. The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. Aliment. Pharmacol. Ther. 41, 54-64 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.41 , pp. 54-64
    • Walters, J.R.1
  • 80
    • 84878666676 scopus 로고    scopus 로고
    • Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids
    • Zhang, J. H. et al. Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G940-G948 (2013).
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.304 , pp. G940-G948
    • Zhang, J.H.1
  • 81
    • 84944754899 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth and prevents the recurrence of ileal pouchitis associated with the infection
    • Weingarden, A. R. et al. Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pouchitis associated with the infection. J. Clin. Gastroenterol. http://dx. doi. org/10. 1097/MCG. 0000000000000427 (2015).
    • (2015) J. Clin. Gastroenterol.
    • Weingarden, A.R.1
  • 82
    • 0028842929 scopus 로고
    • The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation
    • Rodrigues, C. M., Kren, B. T., Steer, C. J. & Setchell, K. D. The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation. Gastroenterology 109, 1835-1844 (1995).
    • (1995) Gastroenterology , vol.109 , pp. 1835-1844
    • Rodrigues, C.M.1    Kren, B.T.2    Steer, C.J.3    Setchell, K.D.4
  • 83
    • 84897138296 scopus 로고    scopus 로고
    • Role of the microbiota in immunity and inflammation
    • Belkaid, Y. & Hand, T. W. Role of the microbiota in immunity and inflammation. Cell 157, 121-141 (2014).
    • (2014) Cell , vol.157 , pp. 121-141
    • Belkaid, Y.1    Hand, T.W.2
  • 84
    • 80054122238 scopus 로고    scopus 로고
    • The antibacterial lectin RegIII promotes the spatial segregation of microbiota and host in the intestine
    • Vaishnava, S. et al. The antibacterial lectin RegIII promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255-258 (2011).
    • (2011) Science , vol.334 , pp. 255-258
    • Vaishnava, S.1
  • 85
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mechanism of action and role in disease
    • Voth, D. E. & Ballard, J. D. Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18, 247-263 (2005).
    • (2005) Clin. Microbiol. Rev. , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 86
    • 84878317467 scopus 로고    scopus 로고
    • Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection
    • El Feghaly, R. E. et al. Markers of intestinal inflammation, not bacterial burden, correlate with clinical outcomes in Clostridium difficile infection. Clin. Infect. Dis. 56, 1713-1721 (2013).
    • (2013) Clin. Infect. Dis. , vol.56 , pp. 1713-1721
    • El Feghaly, R.E.1
  • 87
    • 84907270863 scopus 로고    scopus 로고
    • Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
    • Xu, H. et al. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513, 237-241 (2014).
    • (2014) Nature , vol.513 , pp. 237-241
    • Xu, H.1
  • 88
    • 77955482224 scopus 로고    scopus 로고
    • Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
    • e3
    • Ng, J. et al. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 139, 542-552. e3 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 542-552
    • Ng, J.1
  • 89
    • 84866158239 scopus 로고    scopus 로고
    • Protective role of commensals against Clostridium difficile infection via an IL-1-mediated positive-feedback loop
    • Hasegawa, M. et al. Protective role of commensals against Clostridium difficile infection via an IL-1-mediated positive-feedback loop. J. Immunol. 189, 3085-3091 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 3085-3091
    • Hasegawa, M.1
  • 90
    • 1542287347 scopus 로고    scopus 로고
    • Neutrophil extracellular traps kill bacteria
    • Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535 (2004).
    • (2004) Science , vol.303 , pp. 1532-1535
    • Brinkmann, V.1
  • 91
    • 70350029796 scopus 로고    scopus 로고
    • NETs: A new strategy for using old weapons
    • Papayannopoulos, V. & Zychlinsky, A. NETs: a new strategy for using old weapons. Trends Immunol. 30, 513-521 (2009).
    • (2009) Trends Immunol. , vol.30 , pp. 513-521
    • Papayannopoulos, V.1    Zychlinsky, A.2
  • 92
    • 84883226853 scopus 로고    scopus 로고
    • Role of interleukin 23 signaling in Clostridium difficile colitis
    • Buonomo, E. L. et al. Role of interleukin 23 signaling in Clostridium difficile colitis. J. Infect. Dis. 208, 917-920 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 917-920
    • Buonomo, E.L.1
  • 93
    • 84924181912 scopus 로고    scopus 로고
    • Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile
    • Cowardin, C. A. et al. Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. mBio 6, e02386-e02314 (2015).
    • (2015) MBio , vol.6 , pp. e02314-e02386
    • Cowardin, C.A.1
  • 95
    • 84908121712 scopus 로고    scopus 로고
    • Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage
    • Hasegawa, M. et al. Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage. Immunity 41, 620-632 (2014).
    • (2014) Immunity , vol.41 , pp. 620-632
    • Hasegawa, M.1
  • 96
    • 84871638124 scopus 로고    scopus 로고
    • Fecal microbiota transplantation: Past, present and future
    • Aroniadis, O. C. & Brandt, L. J. Fecal microbiota transplantation: past, present and future. Curr. Opin. Gastroenterol. 29, 79-84 (2013).
    • (2013) Curr. Opin. Gastroenterol. , vol.29 , pp. 79-84
    • Aroniadis, O.C.1    Brandt, L.J.2
  • 98
    • 84929297936 scopus 로고    scopus 로고
    • Dynamics and stabilization of the human gut microbiome during the first year of life
    • Backhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 852 (2015).
    • (2015) Cell Host Microbe , vol.17 , pp. 852
    • Backhed, F.1
  • 99
    • 84860216630 scopus 로고    scopus 로고
    • Microbial exposure during early life has persistent effects on natural killer T cell function
    • Olszak, T. et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336, 489-493 (2012).
    • (2012) Science , vol.336 , pp. 489-493
    • Olszak, T.1
  • 100
    • 84978604736 scopus 로고    scopus 로고
    • First microbial encounters
    • Khoruts, A. First microbial encounters. Nat. Med. 22, 231-232 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 231-232
    • Khoruts, A.1
  • 102
    • 84865175815 scopus 로고    scopus 로고
    • Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation
    • Taur, Y. et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin. Infect. Dis. 55, 905-914 (2012).
    • (2012) Clin. Infect. Dis. , vol.55 , pp. 905-914
    • Taur, Y.1
  • 103
    • 84962251251 scopus 로고    scopus 로고
    • ClinicalTrials. gov
    • US National Library of Science. ClinicalTrials. gov https://clinicaltrials. gov/ct2/show/NCT02269150 (2016).
    • (2016) US National Library of Science
  • 104
    • 84978327773 scopus 로고    scopus 로고
    • Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant
    • Stripling, J. et al. Loss of vancomycin-resistant enterococcus fecal dominance in an organ transplant patient with Clostridium difficile colitis after fecal microbiota transplant. Open Forum Infect Dis 2, ofv078 (2015).
    • (2015) Open Forum Infect Dis , vol.2 , pp. 078
    • Stripling, J.1
  • 105
    • 35348961403 scopus 로고    scopus 로고
    • An ecological and evolutionary perspective on human-microbe mutualism and disease
    • Dethlefsen, L., McFall-Ngai, M. & Relman, D. A. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 449, 811-818 (2007).
    • (2007) Nature , vol.449 , pp. 811-818
    • Dethlefsen, L.1    McFall-Ngai, M.2    Relman, D.A.3
  • 106
    • 84894241861 scopus 로고    scopus 로고
    • Policy: How to regulate faecal transplants
    • Smith, M. B., Kelly, C. & Alm, E. J. Policy: how to regulate faecal transplants. Nature 506, 290-291 (2014).
    • (2014) Nature , vol.506 , pp. 290-291
    • Smith, M.B.1    Kelly, C.2    Alm, E.J.3
  • 107
    • 82955233474 scopus 로고    scopus 로고
    • Treating Clostridium difficile infection with fecal microbiota transplantation
    • Bakken, J. S. et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin. Gastroenterol. Hepatol. 9, 1044-1049 (2011).
    • (2011) Clin. Gastroenterol. Hepatol. , vol.9 , pp. 1044-1049
    • Bakken, J.S.1


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