메뉴 건너뛰기




Volumn 44, Issue 7, 2016, Pages 1050-1060

Kidney versus liver specification of SLC and ABC drug transporters, tight junction molecules, and biomarkers

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ALBUMIN; APOLIPOPROTEIN; BIOLOGICAL MARKER; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; CLAUDIN 6; EXCITATORY AMINO ACID TRANSPORTER 4; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; OCCLUDIN; ORGANIC ANION TRANSPORTER 1; PROTEIN ZO1; PROTEIN ZO2; SODIUM PHOSPHATE COTRANSPORTER 2A; TIGHT JUNCTION PROTEIN; TRANSCRIPTION FACTOR GATA 4; TRANSFERRIN; URATE TRANSPORTER; ORGANIC CATION TRANSPORTER; TRANSCRIPTION FACTOR;

EID: 84975144900     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.068254     Document Type: Article
Times cited : (23)

References (37)
  • 1
    • 69549103730 scopus 로고    scopus 로고
    • Toward a systems level understanding of organic anion and other multispecific drug transporters: A remote sensing and signaling hypothesis
    • Ahn SY and Nigam SK (2009) Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol 76:481-490.
    • (2009) Mol Pharmacol , vol.76 , pp. 481-490
    • Ahn, S.Y.1    Nigam, S.K.2
  • 2
    • 63249110107 scopus 로고    scopus 로고
    • Tight junction claudins and the kidney in sickness and in health
    • Balkovetz DF (2009) Tight junction claudins and the kidney in sickness and in health. Biochim Biophys Acta 1788:858-863.
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 858-863
    • Balkovetz, D.F.1
  • 3
    • 0031893838 scopus 로고    scopus 로고
    • Molecular structure and assembly of the tight junction
    • Denker BM and Nigam SK (1998) Molecular structure and assembly of the tight junction. Am J Physiol 274:F1-F9.
    • (1998) Am J Physiol , vol.274 , pp. F1-F9
    • Denker, B.M.1    Nigam, S.K.2
  • 4
    • 84896132644 scopus 로고    scopus 로고
    • Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming
    • Du Y, Wang J, Jia J, Song N, Xiang C, Xu J, Hou Z, Su X, Liu B, and Jiang T, et al. (2014) Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell 14:394-403.
    • (2014) Cell Stem Cell , vol.14 , pp. 394-403
    • Du, Y.1    Wang, J.2    Jia, J.3    Song, N.4    Xiang, C.5    Xu, J.6    Hou, Z.7    Su, X.8    Liu, B.9    Jiang, T.10
  • 6
    • 71449125977 scopus 로고    scopus 로고
    • Forcing cells to change lineages
    • Graf T and Enver T (2009) Forcing cells to change lineages. Nature 462:587-594.
    • (2009) Nature , vol.462 , pp. 587-594
    • Graf, T.1    Enver, T.2
  • 7
    • 84894491411 scopus 로고    scopus 로고
    • Preclinical studies for induced pluripotent stem cell-based therapeutics
    • Harding J and Mirochnitchenko O (2014) Preclinical studies for induced pluripotent stem cell-based therapeutics. J Biol Chem 289:4585-4593.
    • (2014) J Biol Chem , vol.289 , pp. 4585-4593
    • Harding, J.1    Mirochnitchenko, O.2
  • 8
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, and Glass CK (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38:576-589.
    • (2010) Mol Cell , vol.38 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3    Bertolino, E.4    Lin, Y.C.5    Laslo, P.6    Cheng, J.X.7    Murre, C.8    Singh, H.9    Glass, C.K.10
  • 9
    • 84908074776 scopus 로고    scopus 로고
    • The kidney tight junction (Review)
    • Hou J (2014) The kidney tight junction (Review). Review Int J Mol Med 34:1451-1457.
    • (2014) Review Int J Mol Med , vol.34 , pp. 1451-1457
    • Hou, J.1
  • 10
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
    • Huang P, He Z, Ji S, Sun H, Xiang D, Liu C, Hu Y, Wang X, and Hui L (2011) Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 475:386-389.
    • (2011) Nature , vol.475 , pp. 386-389
    • Huang, P.1    He, Z.2    Ji, S.3    Sun, H.4    Xiang, D.5    Liu, C.6    Hu, Y.7    Wang, X.8    Hui, L.9
  • 14
    • 0030940999 scopus 로고    scopus 로고
    • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    • Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, and Nigam SK (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478.
    • (1997) J Biol Chem , vol.272 , pp. 6471-6478
    • Lopez-Nieto, C.E.1    You, G.2    Bush, K.T.3    Barros, E.J.4    Beier, D.R.5    Nigam, S.K.6
  • 15
    • 84886407915 scopus 로고    scopus 로고
    • Clinical therapy using iPSCs: Hopes and challenges
    • Lu X and Zhao T (2013) Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics 11:294-298.
    • (2013) Genomics Proteomics Bioinformatics , vol.11 , pp. 294-298
    • Lu, X.1    Zhao, T.2
  • 16
    • 84901408474 scopus 로고    scopus 로고
    • Cellular and developmental strategies aimed at kidney tissue engineering
    • Martovetsky G and Nigam SK (2014) Cellular and developmental strategies aimed at kidney tissue engineering. Nephron, Exp Nephrol 126:101.
    • (2014) Nephron, Exp Nephrol , vol.126 , pp. 101
    • Martovetsky, G.1    Nigam, S.K.2
  • 17
    • 84888404447 scopus 로고    scopus 로고
    • Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters
    • Martovetsky G, Tee JB, and Nigam SK (2013) Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol 84:808-823.
    • (2013) Mol Pharmacol , vol.84 , pp. 808-823
    • Martovetsky, G.1    Tee, J.B.2    Nigam, S.K.3
  • 20
    • 78650936423 scopus 로고    scopus 로고
    • Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling
    • Nagle MA, Truong DM, Dnyanmote AV, Ahn SY, Eraly SA, Wu W, and Nigam SK (2011) Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J Biol Chem 286:243-251.
    • (2011) J Biol Chem , vol.286 , pp. 243-251
    • Nagle, M.A.1    Truong, D.M.2    Dnyanmote, A.V.3    Ahn, S.Y.4    Eraly, S.A.5    Wu, W.6    Nigam, S.K.7
  • 22
    • 84888416537 scopus 로고    scopus 로고
    • Concise review: Can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs?
    • Nigam SK (2013) Concise review: can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs? Stem Cells Transl Med 2:993-1000.
    • (2013) Stem Cells Transl Med , vol.2 , pp. 993-1000
    • Nigam, S.K.1
  • 23
    • 84925285641 scopus 로고    scopus 로고
    • What do drug transporters really do?
    • Nigam SK (2015) What do drug transporters really do? Nat Rev Drug Discov 14:29-44.
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 29-44
    • Nigam, S.K.1
  • 25
    • 84946733480 scopus 로고    scopus 로고
    • Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters
    • Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, and Bhatnagar V (2015b) Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters. Clin J Am Soc Nephrol 10:2039-2049.
    • (2015) Clin J Am Soc Nephrol , vol.10 , pp. 2039-2049
    • Nigam, S.K.1    Wu, W.2    Bush, K.T.3    Hoenig, M.P.4    Blantz, R.C.5    Bhatnagar, V.6
  • 27
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya S and Suzuki A (2011) Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475:390-393.
    • (2011) Nature , vol.475 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 28
    • 84903542476 scopus 로고    scopus 로고
    • Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs
    • Simeonov KP and Uppal H (2014) Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs. PLoS One 9:e100134.
    • (2014) PLoS One , vol.9
    • Simeonov, K.P.1    Uppal, H.2
  • 29
    • 84866130250 scopus 로고    scopus 로고
    • Transcription factor-mediated epigenetic reprogramming
    • Sindhu C, Samavarchi-Tehrani P, and Meissner A (2012) Transcription factor-mediated epigenetic reprogramming. J Biol Chem 287:30922-30931.
    • (2012) J Biol Chem , vol.287 , pp. 30922-30931
    • Sindhu, C.1    Samavarchi-Tehrani, P.2    Meissner, A.3
  • 30
    • 79960666822 scopus 로고    scopus 로고
    • Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
    • Torres AM, Dnyanmote AV, Bush KT, Wu W, and Nigam SK (2011) Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem 286:26391-26395.
    • (2011) J Biol Chem , vol.286 , pp. 26391-26395
    • Torres, A.M.1    Dnyanmote, A.V.2    Bush, K.T.3    Wu, W.4    Nigam, S.K.5
  • 31
    • 43749115381 scopus 로고    scopus 로고
    • Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
    • Truong DM, Kaler G, Khandelwal A, Swaan PW, and Nigam SK (2008) Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem 283:8654-8663.
    • (2008) J Biol Chem , vol.283 , pp. 8654-8663
    • Truong, D.M.1    Kaler, G.2    Khandelwal, A.3    Swaan, P.W.4    Nigam, S.K.5
  • 32
    • 79958226930 scopus 로고    scopus 로고
    • Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
    • Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, and Nigam SK (2011) Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res 10:2842-2851.
    • (2011) J Proteome Res , vol.10 , pp. 2842-2851
    • Wikoff, W.R.1    Nagle, M.A.2    Kouznetsova, V.L.3    Tsigelny, I.F.4    Nigam, S.K.5
  • 33
    • 84946739389 scopus 로고    scopus 로고
    • Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors
    • Wu W, Bush KT, Liu HC, Zhu C, Abagyan R, and Nigam SK (2015) Shared ligands between organic anion transporters (OAT1 and OAT6) and odorant receptors. Drug Metab Dispos 43:1855-1863.
    • (2015) Drug Metab Dispos , vol.43 , pp. 1855-1863
    • Wu, W.1    Bush, K.T.2    Liu, H.C.3    Zhu, C.4    Abagyan, R.5    Nigam, S.K.6
  • 34
    • 79954998791 scopus 로고    scopus 로고
    • Remote communication through solute carriers and ATP binding cassette drug transporter pathways: An update on the remote sensing and signaling hypothesis
    • Wu W, Dnyanmote AV, and Nigam SK (2011) Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol Pharmacol 79:795-805.
    • (2011) Mol Pharmacol , vol.79 , pp. 795-805
    • Wu, W.1    Dnyanmote, A.V.2    Nigam, S.K.3
  • 36
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: Establishing competence for gene expression
    • Zaret KS and Carroll JS (2011) Pioneer transcription factors: establishing competence for gene expression. Genes Dev 25:2227-2241.
    • (2011) Genes Dev , vol.25 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 37
    • 84951128933 scopus 로고    scopus 로고
    • Evolutionary analysis and classification of OATs, OCTs, OCTNs, and other SLC22 transporters: Structure-function implications and analysis of sequence motifs
    • Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH, Jr, Wu W, and Nigam SK (2015) Evolutionary analysis and classification of OATs, OCTs, OCTNs, and other SLC22 transporters: Structure-function implications and analysis of sequence motifs. PLoS One 10:e0140569.
    • (2015) PLoS One , vol.10
    • Zhu, C.1    Nigam, K.B.2    Date, R.C.3    Bush, K.T.4    Springer, S.A.5    Saier, M.H.6    Wu, W.7    Nigam, S.K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.