-
1
-
-
78650074746
-
Sclerostin monoclonal antibody therapy with AMG 785: A potential treatment for osteoporosis
-
E. M. Lewiecki, "Sclerostin monoclonal antibody therapy with AMG 785: A potential treatment for osteoporosis, " Expert Opinion on Biological Therapy, vol. 11, no. 1, pp. 117-127, 2011.
-
(2011)
Expert Opinion on Biological Therapy
, vol.11
, Issue.1
, pp. 117-127
-
-
Lewiecki, E.M.1
-
2
-
-
84902687057
-
Anti-sclerostin antibodies: Utility in treatment of osteoporosis
-
B. L. Clarke, "Anti-sclerostin antibodies: utility in treatment of osteoporosis, " Maturitas, vol. 78, no. 3, pp. 199-204, 2014.
-
(2014)
Maturitas
, vol.78
, Issue.3
, pp. 199-204
-
-
Clarke, B.L.1
-
4
-
-
78650958526
-
Singledose, placebo-controlled, randomized study of AMG 785
-
a sclerostin monoclonal antibody
-
D. Padhi, G. Jang, B. Stouch, L. Fang, and E. Posvar, "Singledose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody, " Journal of Bone and Mineral Research, vol. 26, no. 1, pp. 19-26, 2011.
-
(2011)
Journal of Bone and Mineral Research
, vol.26
, Issue.1
, pp. 19-26
-
-
Padhi, D.1
Jang, G.2
Stouch, B.3
Fang, L.4
Posvar, E.5
-
5
-
-
84975100868
-
-
Osteoporosis and Osteopenia, 2013, http: //decisionresources. com/Products-and-Services/Report?r=dbasmd0213.
-
(2013)
Osteoporosis and Osteopenia
-
-
-
6
-
-
79551592979
-
Newapproaches tothe treatment of osteoporosis
-
B. C. Silva and J. P. Bilezikian, "Newapproaches tothe treatment of osteoporosis, " Annual Review of Medicine, vol. 62, pp. 307-322, 2011.
-
(2011)
Annual Review of Medicine
, vol.62
, pp. 307-322
-
-
Silva, B.C.1
Bilezikian, J.P.2
-
7
-
-
79953751008
-
Osteoporosis: Now and the future
-
T. D. Rachner, S. Khosla, and L. C. Hofbauer, "Osteoporosis: now and the future, " The Lancet, vol. 377, no. 9773, pp. 1276-1287, 2011.
-
(2011)
The Lancet
, vol.377
, Issue.9773
, pp. 1276-1287
-
-
Rachner, T.D.1
Khosla, S.2
Hofbauer, L.C.3
-
9
-
-
0030964587
-
The socioeconomic burden of fractures: Today and in the 21st century
-
O. Johnell, "The socioeconomic burden of fractures: today and in the 21st century, " The American Journal of Medicine, vol. 103, no. 2, supplement 1, pp. S20-S26, 1997.
-
(1997)
The American Journal of Medicine
, vol.103
, Issue.2
, pp. S20-S26
-
-
Johnell, O.1
-
10
-
-
84886865090
-
Current options to surgical treatment in osteoporotic fractures
-
G. Marongiu, M. Mastio, and A. Capone, "Current options to surgical treatment in osteoporotic fractures, " Aging Clinical and Experimental Research, vol. 25, supplement 1, pp. S15-S17, 2013.
-
(2013)
Aging Clinical and Experimental Research
, vol.25
, pp. S15-S17
-
-
Marongiu, G.1
Mastio, M.2
Capone, A.3
-
11
-
-
84975150806
-
Management of severe osteoporosis in primary total hip arthroplasty
-
S. C. Mears, "Management of severe osteoporosis in primary total hip arthroplasty, " Current Translational Geriatrics and ExperimentalGerontology Reports, vol. 2, no. 2, pp. 99-104, 2013.
-
(2013)
Current Translational Geriatrics and ExperimentalGerontology Reports
, vol.2
, Issue.2
, pp. 99-104
-
-
Mears, S.C.1
-
12
-
-
84880305680
-
Osteoporosis in the European Union: Medical management, epidemiology and economic burden: A report prepared in collaboration with the InternationalOsteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA)
-
E. Hernlund, A. Svedbom, M. IverGard et al., "Osteoporosis in the European Union: medical management, epidemiology and economic burden: A report prepared in collaboration with the InternationalOsteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA), " Archives of Osteoporosis, vol. 8, no. 1-2, article 136, 2013.
-
(2013)
Archives of Osteoporosis
, vol.8
, Issue.1-2
-
-
Hernlund, E.1
Svedbom, A.2
IverGard, M.3
-
13
-
-
0028799124
-
The worldwide problem of osteoporosis: Insights afforded by epidemiology
-
B. L. Riggs and L. J. Melton III, "The worldwide problem of osteoporosis: insights afforded by epidemiology, " Bone, vol. 17, no. 5, supplement 1, pp. S505-S511, 1995.
-
(1995)
Bone
, vol.17
, Issue.5
, pp. S505-S511
-
-
Riggs, B.L.1
Melton, L.J.2
-
14
-
-
0041630893
-
The natural history of sclerosteosis
-
H. Hamersma, J. Gardner, and P. Beighton, "The natural history of sclerosteosis, " Clinical Genetics, vol. 63, no. 3, pp. 192-197, 2003.
-
(2003)
Clinical Genetics
, vol.63
, Issue.3
, pp. 192-197
-
-
Hamersma, H.1
Gardner, J.2
Beighton, P.3
-
15
-
-
84862248680
-
Sclerostin: Therapeutichorizons basedupon its actions
-
A. G. Costa and J. P. Bilezikian, "Sclerostin: therapeutichorizons basedupon its actions, " CurrentOsteoporosis Reports, vol. 10, no. 1, pp. 64-72, 2012.
-
(2012)
CurrentOsteoporosis Reports
, vol.10
, Issue.1
, pp. 64-72
-
-
Costa, A.G.1
Bilezikian, J.P.2
-
16
-
-
0035282968
-
Increasedbonedensity in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
-
W. Balemans, M. Ebeling, N. Patel et al., "Increasedbonedensity in sclerosteosis is due to the deficiency of a novel secreted protein (SOST), " Human Molecular Genetics, vol. 10, no. 5, pp. 537-543, 2001.
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.5
, pp. 537-543
-
-
Balemans, W.1
Ebeling, M.2
Patel, N.3
-
17
-
-
0035089781
-
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
-
M. E. Brunkow, J. C. Gardner, J. Van Ness et al., "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein, " The American Journal of Human Genetics, vol. 68, no. 3, pp. 577-589, 2001.
-
(2001)
The American Journal of Human Genetics
, vol.68
, Issue.3
, pp. 577-589
-
-
Brunkow, M.E.1
Gardner, J.C.2
Van Ness, J.3
-
18
-
-
10744221383
-
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
-
D. G. Winkler, M. K. Sutherland, J. C. Geoghegan et al., "Osteocyte control of bone formation via sclerostin, a novel BMP antagonist, " The EMBO Journal, vol. 22, no. 23, pp. 6267-6276, 2003.
-
(2003)
The EMBO Journal
, vol.22
, Issue.23
, pp. 6267-6276
-
-
Winkler, D.G.1
Sutherland, M.K.2
Geoghegan, J.C.3
-
19
-
-
78650646959
-
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways
-
C. Krause, O. Korchynskyi, K. de Rooij et al., "Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways, "The Journal of Biological Chemistry, vol. 285, no. 53, pp. 41614-41626, 2010.
-
(2010)
The Journal of Biological Chemistry
, vol.285
, Issue.53
, pp. 41614-41626
-
-
Krause, C.1
Korchynskyi, O.2
De Rooij, K.3
-
20
-
-
80053518269
-
Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
-
A. R. Wijenayaka, M. Kogawa, H. P. Lim, L. F. Bonewald, D. M. Findlay, and G. J. Atkins, "Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway, " PLoS ONE, vol. 6, no. 10, Article ID e25900, 2011.
-
(2011)
PLoS ONE
, vol.6
, Issue.10
-
-
Wijenayaka, A.R.1
Kogawa, M.2
Lim, H.P.3
Bonewald, L.F.4
Findlay, D.M.5
Atkins, G.J.6
-
21
-
-
84921809759
-
A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density
-
R. R. Recker, C. T. Benson, T. Matsumoto et al., "A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density, " Journal of Bone and Mineral Research, vol. 30, no. 2, pp. 216-224, 2015.
-
(2015)
Journal of Bone and Mineral Research
, vol.30
, Issue.2
, pp. 216-224
-
-
Recker, R.R.1
Benson, C.T.2
Matsumoto, T.3
-
22
-
-
21244480924
-
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
-
X. Li, Y. Zhang, H. Kang et al., "Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling, " The Journal of Biological Chemistry, vol. 280, no. 20, pp. 19883-19887, 2005.
-
(2005)
The Journal of Biological Chemistry
, vol.280
, Issue.20
, pp. 19883-19887
-
-
Li, X.1
Zhang, Y.2
Kang, H.3
-
23
-
-
33845994036
-
LRP5mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
-
M. V. Semenov and X. He, "LRP5mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST, "The Journal of Biological Chemistry, vol. 281, no. 50, pp. 38276-38284, 2006.
-
(2006)
The Journal of Biological Chemistry
, vol.281
, Issue.50
, pp. 38276-38284
-
-
Semenov, M.V.1
He, X.2
-
24
-
-
78650482080
-
Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases
-
R. Sugimura and L. Li, "Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases, " Birth Defects Research Part C: Embryo Today: Reviews, vol. 90, no. 4, pp. 243-256, 2010.
-
(2010)
Birth Defects Research Part C: Embryo Today: Reviews
, vol.90
, Issue.4
, pp. 243-256
-
-
Sugimura, R.1
Li, L.2
-
25
-
-
34249978979
-
The Wnt signaling pathway and bone metabolism
-
M. L. Johnson and M. A. Kamel, "The Wnt signaling pathway and bone metabolism, " Current Opinion in Rheumatology, vol. 19, no. 4, pp. 376-382, 2007.
-
(2007)
Current Opinion in Rheumatology
, vol.19
, Issue.4
, pp. 376-382
-
-
Johnson, M.L.1
Kamel, M.A.2
-
26
-
-
84873558051
-
WNTsignaling in bone homeostasis and disease: From human mutations to treatments
-
R. Baron and M. Kneissel, "WNTsignaling in bone homeostasis and disease: from human mutations to treatments, " Nature Medicine, vol. 19, no. 2, pp. 179-192, 2013.
-
(2013)
Nature Medicine
, vol.19
, Issue.2
, pp. 179-192
-
-
Baron, R.1
Kneissel, M.2
-
27
-
-
33646433058
-
Regulation of bone mass by Wnt signaling
-
V. Krishnan, H. U. Bryant, and O. A. MacDougald, "Regulation of bone mass by Wnt signaling, "The Journal of Clinical Investigation, vol. 116, no. 5, pp. 1202-1209, 2006.
-
(2006)
The Journal of Clinical Investigation
, vol.116
, Issue.5
, pp. 1202-1209
-
-
Krishnan, V.1
Bryant, H.U.2
MacDougald, O.A.3
-
28
-
-
17844372752
-
Wnt/-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
-
T. F. Day, X. Guo, L. Garrett-Beal, and Y. Yang, "Wnt/-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis, " Developmental Cell, vol. 8, no. 5, pp. 739-750, 2005.
-
(2005)
Developmental Cell
, vol.8
, Issue.5
, pp. 739-750
-
-
Day, T.F.1
Guo, X.2
Garrett-Beal, L.3
Yang, Y.4
-
29
-
-
20244373613
-
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
-
D. A. Glass II, P. Bialek, J. D. Ahn et al., "Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation, " Developmental Cell, vol. 8, no. 5, pp. 751-764, 2005.
-
(2005)
Developmental Cell
, vol.8
, Issue.5
, pp. 751-764
-
-
Glass, I.I.D.A.1
Bialek, P.2
Ahn, J.D.3
-
30
-
-
80052839741
-
Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells
-
W. Qiu, L. Chen, and M. Kassem, "Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells, " Biochemical and Biophysical Research Communications, vol. 413, no. 1, pp. 98-104, 2011.
-
(2011)
Biochemical and Biophysical Research Communications
, vol.413
, Issue.1
, pp. 98-104
-
-
Qiu, W.1
Chen, L.2
Kassem, M.3
-
31
-
-
84872363711
-
Roles of Wnt signals in bone resorption during physiological and pathological states
-
K. Maeda, N. Takahashi, and Y. Kobayashi, "Roles of Wnt signals in bone resorption during physiological and pathological states, " Journal of Molecular Medicine, vol. 91, no. 1, pp. 15-23, 2013.
-
(2013)
Journal of Molecular Medicine
, vol.91
, Issue.1
, pp. 15-23
-
-
Maeda, K.1
Takahashi, N.2
Kobayashi, Y.3
-
32
-
-
84868290353
-
Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
-
H. Z. Ke, W. G. Richards, X. Li, and M. S. Ominsky, "Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases, " Endocrine Reviews, vol. 33, no. 5, pp. 747-783, 2012.
-
(2012)
Endocrine Reviews
, vol.33
, Issue.5
, pp. 747-783
-
-
Ke, H.Z.1
Richards, W.G.2
Li, X.3
Ominsky, M.S.4
-
33
-
-
18044386744
-
LDL receptor-relatedprotein 5 (LRP5) affects bone accrual and eye development
-
Y. Gong, R. B. Slee, N. Fukai et al., "LDL receptor-relatedprotein 5 (LRP5) affects bone accrual and eye development, " Cell, vol. 107, no. 4, pp. 513-523, 2001.
-
(2001)
Cell
, vol.107
, Issue.4
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
-
34
-
-
0030908846
-
Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)
-
M. L. Johnson, G. Gong, W. Kimberling, S. M. Recker, D. B. Kimmel, and R. R. Recker, "Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13), " American Journal of Human Genetics, vol. 60, no. 6, pp. 1326-1332, 1997.
-
(1997)
American Journal of Human Genetics
, vol.60
, Issue.6
, pp. 1326-1332
-
-
Johnson, M.L.1
Gong, G.2
Kimberling, W.3
Recker, S.M.4
Kimmel, D.B.5
Recker, R.R.6
-
35
-
-
0036138175
-
Amutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
-
R. D. Little, C. Folz, S. P. Manning et al., "Amutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait, " The American Journal of Human Genetics, vol. 70, no. 1, pp. 11-19, 2002.
-
(2002)
The American Journal of Human Genetics
, vol.70
, Issue.1
, pp. 11-19
-
-
Little, R.D.1
Folz, C.2
Manning, S.P.3
-
36
-
-
0037092049
-
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5
-
aWnt coreceptor
-
M. Kato, M. S. Patel, R. Levasseur et al., "Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, aWnt coreceptor, " Journal of Cell Biology, vol. 157, no. 2, pp. 303-314, 2002.
-
(2002)
Journal of Cell Biology
, vol.157
, Issue.2
, pp. 303-314
-
-
Kato, M.1
Patel, M.S.2
Levasseur, R.3
-
37
-
-
10744224854
-
High bone mass in mice expressing a mutant LRP5 gene
-
P. Babij, W. Zhao, C. Small et al., "High bone mass in mice expressing a mutant LRP5 gene, " Journal of Bone and Mineral Research, vol. 18, no. 6, pp. 960-974, 2003.
-
(2003)
Journal of Bone and Mineral Research
, vol.18
, Issue.6
, pp. 960-974
-
-
Babij, P.1
Zhao, W.2
Small, C.3
-
38
-
-
83255192191
-
Biphasic and dosage-dependent regulation of osteoclastogenesis by-catenin
-
W. Wei, D. Zeve, J. M. Suh et al., "Biphasic and dosage-dependent regulation of osteoclastogenesis by-catenin, " Molecular and Cellular Biology, vol. 31, no. 23, pp. 4706-4719, 2011.
-
(2011)
Molecular and Cellular Biology
, vol.31
, Issue.23
, pp. 4706-4719
-
-
Wei, W.1
Zeve, D.2
Suh, J.M.3
-
39
-
-
17844363974
-
Canonical Wnt/-catenin signaling prevents osteoblasts from differentiating into chondrocytes
-
T. P. Hill, D. Später, M. M. Taketo, W. Birchmeier, and C. Hartmann, "Canonical Wnt/-catenin signaling prevents osteoblasts from differentiating into chondrocytes, " Developmental Cell, vol. 8, no. 5, pp. 727-738, 2005.
-
(2005)
Developmental Cell
, vol.8
, Issue.5
, pp. 727-738
-
-
Hill, T.P.1
Später, D.2
Taketo, M.M.3
Birchmeier, W.4
Hartmann, C.5
-
40
-
-
20444376156
-
Essential roleof-catenin in postnatal bone acquisition
-
S. L. Holmen, C. R. Zylstra, A. Mukherjee et al., "Essential roleof-catenin in postnatal bone acquisition, " The Journal of Biological Chemistry, vol. 280, no. 22, pp. 21162-21168, 2005.
-
(2005)
The Journal of Biological Chemistry
, vol.280
, Issue.22
, pp. 21162-21168
-
-
Holmen, S.L.1
Zylstra, C.R.2
Mukherjee, A.3
-
41
-
-
77953407742
-
OsteocyteWnt/-catenin signaling is required for normal bone homeostasis
-
I. Kramer, C. Halleux, H. Keller et al., "OsteocyteWnt/-catenin signaling is required for normal bone homeostasis, " Molecular and Cellular Biology, vol. 30, no. 12, pp. 3071-3085, 2010.
-
(2010)
Molecular and Cellular Biology
, vol.30
, Issue.12
, pp. 3071-3085
-
-
Kramer, I.1
Halleux, C.2
Keller, H.3
-
42
-
-
84874387975
-
CanonicalWnt signaling inhibits osteoclastogenesis independent of osteoprotegerin
-
J. Albers, J. Keller, A. Baranowsky et al., "CanonicalWnt signaling inhibits osteoclastogenesis independent of osteoprotegerin, " The Journal of Cell Biology, vol. 200, no. 4, pp. 537-549, 2013.
-
(2013)
The Journal of Cell Biology
, vol.200
, Issue.4
, pp. 537-549
-
-
Albers, J.1
Keller, J.2
Baranowsky, A.3
-
43
-
-
84931956359
-
The anti-osteoanabolic function of sclerostin is blunted in mice carrying a high bone mass mutation of Lrp5
-
T. A. Yorgan, S. Peters, A. Jeschke et al., "The anti-osteoanabolic function of sclerostin is blunted in mice carrying a high bone mass mutation of Lrp5, " Journal of Bone and Mineral Research, vol. 30, no. 7, pp. 1175-1183, 2015.
-
(2015)
Journal of Bone and Mineral Research
, vol.30
, Issue.7
, pp. 1175-1183
-
-
Yorgan, T.A.1
Peters, S.2
Jeschke, A.3
-
44
-
-
44449099165
-
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
-
X. Li, M. S. Ominsky, Q.-T. Niu et al., "Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength, " Journal of Bone and Mineral Research, vol. 23, no. 6, pp. 860-869, 2008.
-
(2008)
Journal of Bone and Mineral Research
, vol.23
, Issue.6
, pp. 860-869
-
-
Li, X.1
Ominsky, M.S.2
Niu, Q.-T.3
-
45
-
-
79954637641
-
Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through aMEPE-ASARMdependent mechanism
-
G. J. Atkins, P. S. Rowe, H. P. Lim et al., "Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through aMEPE-ASARMdependent mechanism, " Journal of Bone and Mineral Research, vol. 26, no. 7, pp. 1425-1436, 2011.
-
(2011)
Journal of Bone and Mineral Research
, vol.26
, Issue.7
, pp. 1425-1436
-
-
Atkins, G.J.1
Rowe, P.S.2
Lim, H.P.3
-
46
-
-
84937164850
-
Transcriptional profiling of laser capture microdissected subpopulations of the osteoblast lineage provides insight into the early response to sclerostin antibody in rats
-
P. Nioi, S. Taylor, R. Hu et al., "Transcriptional profiling of laser capture microdissected subpopulations of the osteoblast lineage provides insight into the early response to sclerostin antibody in rats, " Journal of Bone andMineral Research, vol. 30, no. 8, pp. 1457-1467, 2015.
-
(2015)
Journal of Bone AndMineral Research
, vol.30
, Issue.8
, pp. 1457-1467
-
-
Nioi, P.1
Taylor, S.2
Hu, R.3
-
47
-
-
84879891175
-
Sclerostin: How humanmutations have helped reveal a new target for the treatment of osteoporosis
-
M. K. Robinson, J. Caminis, and M. E. Brunkow, "Sclerostin: how humanmutations have helped reveal a new target for the treatment of osteoporosis, " Drug Discovery Today, vol. 18, no. 13-14, pp. 637-643, 2013.
-
(2013)
Drug Discovery Today
, vol.18
, Issue.13-14
, pp. 637-643
-
-
Robinson, M.K.1
Caminis, J.2
Brunkow, M.E.3
-
48
-
-
79952118262
-
Sclerostin: Current knowledge and future perspectives
-
M. J. C. Moester, S. E. Papapoulos, C. W. G. M. Löwik, and R. L. van Bezooijen, "Sclerostin: current knowledge and future perspectives, " Calcified Tissue International, vol. 87, no. 2, pp. 99-107, 2010.
-
(2010)
Calcified Tissue International
, vol.87
, Issue.2
, pp. 99-107
-
-
Moester, M.J.C.1
Papapoulos, S.E.2
Löwik, C.W.G.M.3
Van Bezooijen, R.L.4
-
49
-
-
84896284222
-
Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases
-
E. M. Lewiecki, "Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases, " Therapeutic Advances in Musculoskeletal Disease, vol. 6, no. 2, pp. 48-57, 2014.
-
(2014)
Therapeutic Advances in Musculoskeletal Disease
, vol.6
, Issue.2
, pp. 48-57
-
-
Lewiecki, E.M.1
-
50
-
-
65549152230
-
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
-
X. Li, M. S. Ominsky, K. S. Warmington et al., "Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis, " Journal of Bone andMineral Research, vol. 24, no. 4, pp. 578-588, 2009.
-
(2009)
Journal of Bone AndMineral Research
, vol.24
, Issue.4
, pp. 578-588
-
-
Li, X.1
Ominsky, M.S.2
Warmington, K.S.3
-
51
-
-
84898764426
-
Bone matrix quality after sclerostin antibody treatment
-
R. D. Ross, L. H. Edwards, A. S. Acerbo et al., "Bone matrix quality after sclerostin antibody treatment, " Journal of Bone and Mineral Research, vol. 29, no. 7, pp. 1597-1607, 2014.
-
(2014)
Journal of Bone and Mineral Research
, vol.29
, Issue.7
, pp. 1597-1607
-
-
Ross, R.D.1
Edwards, L.H.2
Acerbo, A.S.3
-
52
-
-
77953481395
-
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength
-
M. S. Ominsky, F. Vlasseros, J. Jolette et al., "Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength, " Journal of Bone and Mineral Research, vol. 25, no. 5, pp. 948-959, 2010.
-
(2010)
Journal of Bone and Mineral Research
, vol.25
, Issue.5
, pp. 948-959
-
-
Ominsky, M.S.1
Vlasseros, F.2
Jolette, J.3
-
53
-
-
84894866129
-
Multiple doses of sclerostin antibody romosozumab in healthy men and postmenopausal womenwith lowbone mass: A randomized, doubleblind, placebo-controlled study
-
D. Padhi, M. Allison, A. J. Kivitz et al., "Multiple doses of sclerostin antibody romosozumab in healthy men and postmenopausal womenwith lowbone mass: A randomized, doubleblind, placebo-controlled study, " Journal of Clinical Pharmacology, vol. 54, no. 2, pp. 168-178, 2014.
-
(2014)
Journal of Clinical Pharmacology
, vol.54
, Issue.2
, pp. 168-178
-
-
Padhi, D.1
Allison, M.2
Kivitz, A.J.3
-
54
-
-
23744447531
-
Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
-
M. R. McClung, J. SanMartin, P. D. Miller et al., "Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass, " Archives of Internal Medicine, vol. 165, no. 15, pp. 1762-1768, 2005.
-
(2005)
Archives of Internal Medicine
, vol.165
, Issue.15
, pp. 1762-1768
-
-
McClung, M.R.1
SanMartin, J.2
Miller, P.D.3
-
55
-
-
84893044528
-
Romosozumab in postmenopausal women with low bone mineral density
-
M. R. McClung, A. Grauer, S. Boonen et al., "Romosozumab in postmenopausal women with low bone mineral density, " The New England Journal of Medicine, vol. 370, no. 5, pp. 412-420, 2014.
-
(2014)
The New England Journal of Medicine
, vol.370
, Issue.5
, pp. 412-420
-
-
McClung, M.R.1
Grauer, A.2
Boonen, S.3
-
56
-
-
84975107282
-
OP0251 effects of 2 years of treatment with romosozumab followed by 1 year of denosumab or placebo in postmenopausal women with low bone mineral density
-
M. R. McClung, A. Chines, J. P. Brown et al., "OP0251 effects of 2 years of treatment with romosozumab followed by 1 year of denosumab or placebo in postmenopausal women with low bone mineral density, " Annals of the Rheumatic Diseases, vol. 74, supplement 2, pp. 166-167, 2015.
-
(2015)
Annals of the Rheumatic Diseases
, vol.74
, pp. 166-167
-
-
McClung, M.R.1
Chines, A.2
Brown, J.P.3
-
57
-
-
84897586287
-
Single-and multiple-dose randomized studies of blosozumab, a monoclonal antibody against sclerostin, in healthy postmenopausal women
-
J. McColm, L. Hu, T. Womack, C. C. Tang, and A. Y. Chiang, "Single-and multiple-dose randomized studies of blosozumab, a monoclonal antibody against sclerostin, in healthy postmenopausal women, " Journal of Bone andMineral Research, vol. 29, no. 4, pp. 935-943, 2014.
-
(2014)
Journal of Bone AndMineral Research
, vol.29
, Issue.4
, pp. 935-943
-
-
McColm, J.1
Hu, L.2
Womack, T.3
Tang, C.C.4
Chiang, A.Y.5
-
58
-
-
84930642961
-
The effect of discontinuing treatment with blosozumab: Follow-up results of a phase 2 randomized clinical trial in postmenopausal women with low bone mineral density
-
C. P. Recknor, R. R. Recker, C. T. Benson et al., "The effect of discontinuing treatment with blosozumab: follow-up results of a phase 2 randomized clinical trial in postmenopausal women with low bone mineral density, " Journal of Bone and Mineral Research, vol. 30, no. 9, pp. 1717-1725, 2015.
-
(2015)
Journal of Bone and Mineral Research
, vol.30
, Issue.9
, pp. 1717-1725
-
-
Recknor, C.P.1
Recker, R.R.2
Benson, C.T.3
-
60
-
-
84920159820
-
Mechanical load increases in bone formation via a sclerostin-independent pathway
-
A. Morse, M. M. McDonald, N. H. Kelly et al., "Mechanical load increases in bone formation via a sclerostin-independent pathway, " Journal of Bone and Mineral Research, vol. 29, no. 1, pp. 2456-2467, 2014.
-
(2014)
Journal of Bone and Mineral Research
, vol.29
, Issue.1
, pp. 2456-2467
-
-
Morse, A.1
McDonald, M.M.2
Kelly, N.H.3
-
61
-
-
84890100598
-
Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity
-
M.-K. Chang, I. Kramer, H. Keller et al., "Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity, " Journal of Bone and Mineral Research, vol. 29, no. 1, pp. 29-42, 2014.
-
(2014)
Journal of Bone and Mineral Research
, vol.29
, Issue.1
, pp. 29-42
-
-
Chang, M.-K.1
Kramer, I.2
Keller, H.3
-
62
-
-
84909957930
-
Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength
-
A. Morse, N. Y. C. Yu, L. Peacock et al., "Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength, " Bone, vol. 71, pp. 155-163, 2015.
-
(2015)
Bone
, vol.71
, pp. 155-163
-
-
Morse, A.1
Yu, N.Y.C.2
Peacock, L.3
-
63
-
-
80052478948
-
Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats
-
X. Li, M. S. Ominsky, K. S. Warmington et al., "Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats, " Endocrinology, vol. 152, no. 9, pp. 3312-3322, 2011.
-
(2011)
Endocrinology
, vol.152
, Issue.9
, pp. 3312-3322
-
-
Li, X.1
Ominsky, M.S.2
Warmington, K.S.3
-
64
-
-
0141796739
-
The effects of parathyroid hormone, alendronate, or both in men with osteoporosis
-
J. S. Finkelstein, A. Hayes, J. L. Hunzelman, J. J. Wyland, H. Lee, and R. M. Neer, "The effects of parathyroid hormone, alendronate, or both in men with osteoporosis, " The New England Journal of Medicine, vol. 349, no. 13, pp. 1216-1226, 2003.
-
(2003)
The New England Journal of Medicine
, vol.349
, Issue.13
, pp. 1216-1226
-
-
Finkelstein, J.S.1
Hayes, A.2
Hunzelman, J.L.3
Wyland, J.J.4
Lee, H.5
Neer, R.M.6
-
65
-
-
33747682160
-
Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men
-
J. S. Finkelstein, B. Z. Leder, S.-A. M. Burnett et al., "Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men, " The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 8, pp. 2882-2887, 2006.
-
(2006)
The Journal of Clinical Endocrinology & Metabolism
, vol.91
, Issue.8
, pp. 2882-2887
-
-
Finkelstein, J.S.1
Leder, B.Z.2
Burnett, S.-A.M.3
-
66
-
-
84878535482
-
Time-dependent effects of sclerostin antibody on a mouse fracture healing model
-
L. Cui, H. Cheng, C. Song et al., "Time-dependent effects of sclerostin antibody on a mouse fracture healing model, " Journal of Musculoskeletal & Neuronal Interactions, vol. 13, no. 2, pp. 178-184, 2013.
-
(2013)
Journal of Musculoskeletal & Neuronal Interactions
, vol.13
, Issue.2
, pp. 178-184
-
-
Cui, L.1
Cheng, H.2
Song, C.3
-
67
-
-
84903303547
-
Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats
-
P. K. Suen, Y.-X. He, D. H. K. Chow et al., "Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats, " Journal of Orthopaedic Research, vol. 32, no. 8, pp. 997-1005, 2014.
-
(2014)
Journal of Orthopaedic Research
, vol.32
, Issue.8
, pp. 997-1005
-
-
Suen, P.K.1
He, Y.-X.2
Chow, D.H.K.3
-
68
-
-
79955635177
-
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
-
M. S. Ominsky, C. Li, X. Li et al., "Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones, " Journal of Bone and Mineral Research, vol. 26, no. 5, pp. 1012-1021, 2011.
-
(2011)
Journal of Bone and Mineral Research
, vol.26
, Issue.5
, pp. 1012-1021
-
-
Ominsky, M.S.1
Li, C.2
Li, X.3
-
69
-
-
84865509876
-
Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats
-
M. M. McDonald, A. Morse, K. Mikulec et al., "Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats, " Journal of Orthopaedic Research, vol. 30, no. 10, pp. 1541-1548, 2012.
-
(2012)
Journal of Orthopaedic Research
, vol.30
, Issue.10
, pp. 1541-1548
-
-
McDonald, M.M.1
Morse, A.2
Mikulec, K.3
-
70
-
-
84870243397
-
Effects of sclerostin antibody on healing of a non-critical size femoral bone defect
-
M. U. Jawad, K. E. Fritton, T. Ma et al., "Effects of sclerostin antibody on healing of a non-critical size femoral bone defect, " Journal of Orthopaedic Research, vol. 31, no. 1, pp. 155-163, 2013.
-
(2013)
Journal of Orthopaedic Research
, vol.31
, Issue.1
, pp. 155-163
-
-
Jawad, M.U.1
Fritton, K.E.2
Ma, T.3
-
71
-
-
84954394462
-
Sclerostin antibody treatment improves fracture outcomes in a type i diabetic mouse model
-
C. S. Yee, L. Xie, S. Hatsell et al., "Sclerostin antibody treatment improves fracture outcomes in a type i diabetic mouse model, " Bone, vol. 82, pp. 122-134, 2016.
-
(2016)
Bone
, vol.82
, pp. 122-134
-
-
Yee, C.S.1
Xie, L.2
Hatsell, S.3
-
72
-
-
84880166280
-
Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model
-
M. S. Virk, F. Alaee, H. Tang, M. S. Ominsky, H. Z. Ke, and J. R. Lieberman, "Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model, "The Journal of Bone&Joint Surgery-American Volume, vol. 95, no. 8, pp. 694-701, 2013.
-
(2013)
The Journal of Bone&Joint Surgery-American Volume
, vol.95
, Issue.8
, pp. 694-701
-
-
Virk, M.S.1
Alaee, F.2
Tang, H.3
Ominsky, M.S.4
Ke, H.Z.5
Lieberman, J.R.6
-
73
-
-
84890536535
-
Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model
-
F. Alaee, M. S. Virk, H. Tang et al., "Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model, " Journal of Orthopaedic Research, vol. 32, no. 2, pp. 197-203, 2014.
-
(2014)
Journal of Orthopaedic Research
, vol.32
, Issue.2
, pp. 197-203
-
-
Alaee, F.1
Virk, M.S.2
Tang, H.3
-
75
-
-
84865490988
-
Strongly enhanced levels of sclerostin during human fracture healing
-
K. Sarahrudi, A. Thomas, C. Albrecht, and S. Aharinejad, "Strongly enhanced levels of sclerostin during human fracture healing, " Journal of Orthopaedic Research, vol. 30, no. 10, pp. 1549-1555, 2012.
-
(2012)
Journal of Orthopaedic Research
, vol.30
, Issue.10
, pp. 1549-1555
-
-
Sarahrudi, K.1
Thomas, A.2
Albrecht, C.3
Aharinejad, S.4
-
76
-
-
77956822573
-
Sclerostin antibody treatment enhances metaphyseal bone healing in rats
-
F. Agholme, X. Li, H. Isaksson, H. Z. Ke, and P. Aspenberg, "Sclerostin antibody treatment enhances metaphyseal bone healing in rats, " Journal of Bone and Mineral Research, vol. 25, no. 11, pp. 2412-2418, 2010.
-
(2010)
Journal of Bone and Mineral Research
, vol.25
, Issue.11
, pp. 2412-2418
-
-
Agholme, F.1
Li, X.2
Isaksson, H.3
Ke, H.Z.4
Aspenberg, P.5
-
77
-
-
84867570636
-
Sclerostin antibody increases bone volume and enhances implant fixation in a rat model
-
A. S. Virdi, M. Liu, K. Sena et al., "Sclerostin antibody increases bone volume and enhances implant fixation in a rat model, " The Journal of Bone & Joint Surgery-American Volume, vol. 94, no. 18, pp. 1670-1680, 2012.
-
(2012)
The Journal of Bone & Joint Surgery-American Volume
, vol.94
, Issue.18
, pp. 1670-1680
-
-
Virdi, A.S.1
Liu, M.2
Sena, K.3
-
78
-
-
84870317669
-
Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model
-
S. Liu, A. S. Virdi, K. Sena, and D. R. Sumner, "Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model, " Arthritis and Rheumatism, vol. 64, no. 12, pp. 4012-4020, 2012.
-
(2012)
Arthritis and Rheumatism
, vol.64
, Issue.12
, pp. 4012-4020
-
-
Liu, S.1
Virdi, A.S.2
Sena, K.3
Sumner, D.R.4
-
79
-
-
84921692188
-
Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis
-
A. S. Virdi, J. Irish, K. Sena et al., "Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis, " The Journal of Bone & Joint Surgery-AmericanVolume, vol. 97, no. 2, pp. 133-140, 2015.
-
(2015)
The Journal of Bone & Joint Surgery-AmericanVolume
, vol.97
, Issue.2
, pp. 133-140
-
-
Virdi, A.S.1
Irish, J.2
Sena, K.3
-
80
-
-
70349920691
-
A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis
-
A. Eddleston, M. Marenzana, A. R. Moore et al., "A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis, " Journal of Bone and Mineral Research, vol. 24, no. 10, pp. 1662-1671, 2009.
-
(2009)
Journal of Bone and Mineral Research
, vol.24
, Issue.10
, pp. 1662-1671
-
-
Eddleston, A.1
Marenzana, M.2
Moore, A.R.3
-
81
-
-
84883818516
-
Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
-
X.-X. Chen, W. Baum, D. Dwyer et al., "Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis, " Annals of the Rheumatic Diseases, vol. 72, no. 10, pp. 1732-1736, 2013.
-
(2013)
Annals of the Rheumatic Diseases
, vol.72
, Issue.10
, pp. 1732-1736
-
-
Chen, X.-X.1
Baum, W.2
Dwyer, D.3
-
82
-
-
84873964702
-
Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus
-
C. Hamann, M. Rauner, Y. Höhna et al., "Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus, " Journal of Bone and Mineral Research, vol. 28, no. 3, pp. 627-638, 2013.
-
(2013)
Journal of Bone and Mineral Research
, vol.28
, Issue.3
, pp. 627-638
-
-
Hamann, C.1
Rauner, M.2
Höhna, Y.3
-
83
-
-
84872844733
-
Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta
-
B. P. Sinder, M. M. Eddy, M. S. Ominsky, M. S. Caird, J. C. Marini, and K. M. Kozloff, "Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta, " Journal of Bone and Mineral Research, vol. 28, no. 1, pp. 73-80, 2013.
-
(2013)
Journal of Bone and Mineral Research
, vol.28
, Issue.1
, pp. 73-80
-
-
Sinder, B.P.1
Eddy, M.M.2
Ominsky, M.S.3
Caird, M.S.4
Marini, J.C.5
Kozloff, K.M.6
-
84
-
-
84942783491
-
The potential use of antisclerostin therapy in chronic kidney disease- mineral and bone disorder
-
A. G. Costa, J. P. Bilezikian, and E. M. Lewiecki, "The potential use of antisclerostin therapy in chronic kidney disease- mineral and bone disorder, " Current Opinion in Nephrology and Hypertension, vol. 24, no. 4, pp. 324-329, 2015.
-
(2015)
Current Opinion in Nephrology and Hypertension
, vol.24
, Issue.4
, pp. 324-329
-
-
Costa, A.G.1
Bilezikian, J.P.2
Lewiecki, E.M.3
-
85
-
-
84940112283
-
Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model
-
Y. Ren, X. Han, S. P. Ho et al., "Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model, " FASEB Journal, vol. 29, no. 7, pp. 2702-2711, 2015.
-
(2015)
FASEB Journal
, vol.29
, Issue.7
, pp. 2702-2711
-
-
Ren, Y.1
Han, X.2
Ho, S.P.3
-
86
-
-
84903529224
-
Effect of sclerostin antibody treatment in a mouse model of severe osteogenesis imperfecta
-
A. Roschger, P. Roschger, P. Keplingter et al., "Effect of sclerostin antibody treatment in a mouse model of severe osteogenesis imperfecta, " Bone, vol. 66, pp. 182-188, 2014.
-
(2014)
Bone
, vol.66
, pp. 182-188
-
-
Roschger, A.1
Roschger, P.2
Keplingter, P.3
-
87
-
-
17644376504
-
Intravenous neridronate in children with osteogenesis imperfecta: A randomized controlled study
-
D. Gatti, F. Antoniazzi, R. Prizzi et al., "Intravenous neridronate in children with osteogenesis imperfecta: A randomized controlled study, " Journal of Bone andMineral Research, vol. 20, no. 5, pp. 758-763, 2005.
-
(2005)
Journal of Bone AndMineral Research
, vol.20
, Issue.5
, pp. 758-763
-
-
Gatti, D.1
Antoniazzi, F.2
Prizzi, R.3
-
88
-
-
2342567864
-
Skeletal effects and functional outcome with olpadronate in children with osteogenesis imperfecta: A 2-year randomised placebo-controlled study
-
R. Sakkers, D. Kok, R. Engelbert et al., "Skeletal effects and functional outcome with olpadronate in children with osteogenesis imperfecta: A 2-year randomised placebo-controlled study, " The Lancet, vol. 363, no. 9419, pp. 1427-1431, 2004.
-
(2004)
The Lancet
, vol.363
, Issue.9419
, pp. 1427-1431
-
-
Sakkers, R.1
Kok, D.2
Engelbert, R.3
-
89
-
-
52949116400
-
Bisphosphonate-induced osteopetrosis: Novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases
-
M. P. Whyte, W. H. McAlister, D. V. Novack, K. L. Clements, P. L. Schoenecker, and D. Wenkert, "Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases, " Journal of Bone and Mineral Research, vol. 23, no. 10, pp. 1698-1707, 2008.
-
(2008)
Journal of Bone and Mineral Research
, vol.23
, Issue.10
, pp. 1698-1707
-
-
Whyte, M.P.1
McAlister, W.H.2
Novack, D.V.3
Clements, K.L.4
Schoenecker, P.L.5
Wenkert, D.6
-
90
-
-
79951705431
-
Alendronate for the treatment of pediatric osteogenesis imperfecta: A randomized placebo-controlled study
-
L. M. Ward, F. Rauch, M. P. Whyte et al., "Alendronate for the treatment of pediatric osteogenesis imperfecta: A randomized placebo-controlled study, " Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 2, pp. 355-364, 2011.
-
(2011)
Journal of Clinical Endocrinology and Metabolism
, vol.96
, Issue.2
, pp. 355-364
-
-
Ward, L.M.1
Rauch, F.2
Whyte, M.P.3
-
91
-
-
67649638902
-
Risedronate in the treatment of mild pediatric osteogenesis imperfecta: A randomized placebo-controlled study
-
F. Rauch, C. F. Munns, C. Land, M. Cheung, and F. H. Glorieux, "Risedronate in the treatment of mild pediatric osteogenesis imperfecta: A randomized placebo-controlled study, " Journal of Bone and Mineral Research, vol. 24, no. 7, pp. 1282-1289, 2009.
-
(2009)
Journal of Bone and Mineral Research
, vol.24
, Issue.7
, pp. 1282-1289
-
-
Rauch, F.1
Munns, C.F.2
Land, C.3
Cheung, M.4
Glorieux, F.H.5
-
92
-
-
19044396835
-
Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement
-
A. D. Letocha, H. L. Cintas, J. F. Troendle et al., "Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement, " Journal of Bone andMineral Research, vol. 20, no. 6, pp. 977-986, 2005.
-
(2005)
Journal of Bone AndMineral Research
, vol.20
, Issue.6
, pp. 977-986
-
-
Letocha, A.D.1
Cintas, H.L.2
Troendle, J.F.3
-
93
-
-
0036001310
-
Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety
-
J. L. Vahle, M. Sato, G. G. Long et al., "Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety, " Toxicologic Pathology, vol. 30, no. 3, pp. 312-321, 2002.
-
(2002)
Toxicologic Pathology
, vol.30
, Issue.3
, pp. 312-321
-
-
Vahle, J.L.1
Sato, M.2
Long, G.G.3
-
94
-
-
0037304052
-
Positive linear growth and bone responses to growth hormone treatment in children with types III and IV osteogenesis imperfecta: High predictive value of the carboxyterminal propeptide of type i procollagen
-
J. C. Marini, E. Hopkins, F. H. Glorieux et al., "Positive linear growth and bone responses to growth hormone treatment in children with types III and IV osteogenesis imperfecta: high predictive value of the carboxyterminal propeptide of type I procollagen, " Journal of Bone and Mineral Research, vol. 18, no. 2, pp. 237-243, 2003.
-
(2003)
Journal of Bone and Mineral Research
, vol.18
, Issue.2
, pp. 237-243
-
-
Marini, J.C.1
Hopkins, E.2
Glorieux, F.H.3
-
95
-
-
84874412598
-
Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
-
M. Roudier, X. Li, Q.-T. Niu et al., "Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury, " Arthritis and Rheumatism, vol. 65, no. 3, pp. 721-731, 2013.
-
(2013)
Arthritis and Rheumatism
, vol.65
, Issue.3
, pp. 721-731
-
-
Roudier, M.1
Li, X.2
Niu, Q.-T.3
-
96
-
-
84900813623
-
Involvement of the Wnt-catenin signalling antagonists, sclerostin and dickkopf-related protein 1
-
in chronic periodontitis
-
M. H. Napimoga, C. Nametala, F. L. Da Silva et al., "Involvement of the Wnt-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis, " Journal of Clinical Periodontology, vol. 41, no. 6, pp. 550-557, 2014.
-
(2014)
Journal of Clinical Periodontology
, vol.41
, Issue.6
, pp. 550-557
-
-
Napimoga, M.H.1
Nametala, C.2
Da Silva, F.L.3
-
97
-
-
84903216781
-
Dental and periodontal phenotype in sclerostin knockout mice
-
U. Kuchler, U. Y. Schwarze, T. Dobsak et al., "Dental and periodontal phenotype in sclerostin knockout mice, " International Journal of Oral Science, vol. 6, no. 2, pp. 70-76, 2014.
-
(2014)
International Journal of Oral Science
, vol.6
, Issue.2
, pp. 70-76
-
-
Kuchler, U.1
Schwarze, U.Y.2
Dobsak, T.3
-
98
-
-
84931826722
-
Activation of the canonical Wnt signaling pathway induces cementum regeneration
-
P. Han, S. Ivanovski, R. Crawford, and Y. Xiao, "Activation of the canonical Wnt signaling pathway induces cementum regeneration, " Journal of Bone andMineral Research, vol. 30, no. 7, pp. 1160-1174, 2015.
-
(2015)
Journal of Bone AndMineral Research
, vol.30
, Issue.7
, pp. 1160-1174
-
-
Han, P.1
Ivanovski, S.2
Crawford, R.3
Xiao, Y.4
-
99
-
-
84886247936
-
Sclerostin antibody stimulates bone regeneration after experimental periodontitis
-
A. D. Taut, Q. Jin, J.-H. Chung et al., "Sclerostin antibody stimulates bone regeneration after experimental periodontitis, " Journal of Bone and Mineral Research, vol. 28, no. 11, pp. 2347-2356, 2013.
-
(2013)
Journal of Bone and Mineral Research
, vol.28
, Issue.11
, pp. 2347-2356
-
-
Taut, A.D.1
Jin, Q.2
Chung, J.-H.3
-
100
-
-
84928011338
-
Sclerostin antibody treatment causes greater alveolar crest height and bone mass in an ovariectomized rat model of localized periodontitis
-
H. Chen, X. Xu, M. Liu et al., "Sclerostin antibody treatment causes greater alveolar crest height and bone mass in an ovariectomized rat model of localized periodontitis, " Bone, vol. 76, pp. 141-148, 2015.
-
(2015)
Bone
, vol.76
, pp. 141-148
-
-
Chen, H.1
Xu, X.2
Liu, M.3
-
101
-
-
1442278409
-
Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review
-
K. G. Murphy and J. C. Gunsolley, "Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review, " Annals of Periodontology, vol. 8, no. 1, pp. 266-302, 2003.
-
(2003)
Annals of Periodontology
, vol.8
, Issue.1
, pp. 266-302
-
-
Murphy, K.G.1
Gunsolley, J.C.2
-
102
-
-
84911907516
-
Multiphasic scaffolds for periodontal tissue engineering
-
S. Ivanovski, C. Vaquette, S. Gronthos, D. W. Hutmacher, and P. M. Bartold, "Multiphasic scaffolds for periodontal tissue engineering, " Journal ofDental Research, vol. 93, no. 12, pp. 1212-1221, 2014.
-
(2014)
Journal OfDental Research
, vol.93
, Issue.12
, pp. 1212-1221
-
-
Ivanovski, S.1
Vaquette, C.2
Gronthos, S.3
Hutmacher, D.W.4
Bartold, P.M.5
-
103
-
-
84877641819
-
The relation between renal function and serum sclerostin in adult patients with CKD
-
S. Pelletier, L. Dubourg, M.-C. Carlier, A. Hadj-Aissa, and D. Fouque, "The relation between renal function and serum sclerostin in adult patients with CKD, " Clinical Journal of the American Society of Nephrology, vol. 8, no. 5, pp. 819-823, 2013.
-
(2013)
Clinical Journal of the American Society of Nephrology
, vol.8
, Issue.5
, pp. 819-823
-
-
Pelletier, S.1
Dubourg, L.2
Carlier, M.-C.3
Hadj-Aissa, A.4
Fouque, D.5
-
104
-
-
84907647155
-
Serum sclerostin and adverse outcomes in nondialyzed chronic kidney disease patients
-
M. Kanbay, D. Siriopol, M. Saglam et al., "Serum sclerostin and adverse outcomes in nondialyzed chronic kidney disease patients, " Journal of Clinical Endocrinology andMetabolism, vol. 99, no. 10, pp. E1854-E1861, 2014.
-
(2014)
Journal of Clinical Endocrinology AndMetabolism
, vol.99
, Issue.10
, pp. E1854-E1861
-
-
Kanbay, M.1
Siriopol, D.2
Saglam, M.3
-
105
-
-
84885142378
-
Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: A cross-sectional study
-
V. M. Brandenburg, R. Kramann, R. Koos et al., "Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: A cross-sectional study, " BMC Nephrology, vol. 14, article 219, 2013.
-
(2013)
BMC Nephrology
, vol.14
-
-
Brandenburg, V.M.1
Kramann, R.2
Koos, R.3
-
106
-
-
84875993926
-
Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy
-
R. Kramann, V. M. Brandenburg, L. J. Schurgers et al., "Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy, " NephrologyDialysis Transplantation, vol. 28, no. 4, pp. 856-868, 2013.
-
(2013)
NephrologyDialysis Transplantation
, vol.28
, Issue.4
, pp. 856-868
-
-
Kramann, R.1
Brandenburg, V.M.2
Schurgers, L.J.3
-
107
-
-
54949147219
-
Matrix Gla-protein: The calcification inhibitor in need of Vitamin K
-
L. J. Schurgers, E. C. M. Cranenburg, and C. Vermeer, "Matrix Gla-protein: the calcification inhibitor in need of vitamin K, " Thrombosis and Haemostasis, vol. 100, no. 4, pp. 593-603, 2008.
-
(2008)
Thrombosis and Haemostasis
, vol.100
, Issue.4
, pp. 593-603
-
-
Schurgers, L.J.1
Cranenburg, E.C.M.2
Vermeer, C.3
-
108
-
-
84859327104
-
A case-control study of calciphylaxis in Japanese endstage renal disease patients
-
M. Hayashi, I. Takamatsu, Y. Kanno, T. Yoshida, T. Abe, and Y. Sato, "A case-control study of calciphylaxis in Japanese endstage renal disease patients, " Nephrology Dialysis Transplantation, vol. 27, no. 4, pp. 1580-1584, 2012.
-
(2012)
Nephrology Dialysis Transplantation
, vol.27
, Issue.4
, pp. 1580-1584
-
-
Hayashi, M.1
Takamatsu, I.2
Kanno, Y.3
Yoshida, T.4
Abe, T.5
Sato, Y.6
-
109
-
-
33644823090
-
Bone morphogenetic proteins and their antagonists: The sclerostin paradigm
-
R. L. van Bezooijen, S. E. Papapoulos, and C. W. Löwik, "Bone morphogenetic proteins and their antagonists: the sclerostin paradigm, " Journal of Endocrinological Investigation, vol. 28, no. 8, supplement, pp. 15-17, 2005.
-
(2005)
Journal of Endocrinological Investigation
, vol.28
, Issue.8
, pp. 15-17
-
-
Van Bezooijen, R.L.1
Papapoulos, S.E.2
Löwik, C.W.3
-
110
-
-
84922803328
-
Uremic toxicity and sclerostin in chronic kidney disease patients
-
L. Desjardins, S. Liabeuf, R. B. Oliveira et al., "Uremic toxicity and sclerostin in chronic kidney disease patients, " Nephrologie & therapeutique, vol. 10, no. 6, pp. 463-470, 2014.
-
(2014)
Nephrologie & Therapeutique
, vol.10
, Issue.6
, pp. 463-470
-
-
Desjardins, L.1
Liabeuf, S.2
Oliveira, R.B.3
-
111
-
-
84885664875
-
Sclerostin: Another bonerelated protein related to all-causemortality in haemodialysis
-
L. Viaene, G. J. Behets, K. Claes et al., "Sclerostin: Another bonerelated protein related to all-causemortality in haemodialysis" Nephrology Dialysis Transplantation, vol. 28, no. 12, pp. 3024-3030, 2013.
-
(2013)
Nephrology Dialysis Transplantation
, vol.28
, Issue.12
, pp. 3024-3030
-
-
Viaene, L.1
Behets, G.J.2
Claes, K.3
-
112
-
-
84922549146
-
High levels of circulating sclerostin are associated with better cardiovascular survival in incident dialysis patients: Results from the NECOSAD study
-
C. Drechsler, P. Evenepoel, M. G. Vervloet et al., "High levels of circulating sclerostin are associated with better cardiovascular survival in incident dialysis patients: results from the NECOSAD study, " Nephrology Dialysis Transplantation, vol. 30, no. 2, pp. 288-293, 2015.
-
(2015)
Nephrology Dialysis Transplantation
, vol.30
, Issue.2
, pp. 288-293
-
-
Drechsler, C.1
Evenepoel, P.2
Vervloet, M.G.3
-
113
-
-
84922932317
-
Anti-sclerostin antibody treatment in a ratmodel of progressive renal osteodystrophy
-
S. M. Moe, N. X. Chen, C. L. Newman et al., "Anti-sclerostin antibody treatment in a ratmodel of progressive renal osteodystrophy, " Journal of Bone andMineral Research, vol. 30, no. 3, pp. 499-509, 2015.
-
(2015)
Journal of Bone AndMineral Research
, vol.30
, Issue.3
, pp. 499-509
-
-
Moe, S.M.1
Chen, N.X.2
Newman, C.L.3
-
114
-
-
84928344693
-
Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions
-
C. L. Newman, N. X. Chen, E. Smith et al., "Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions, " Bone, vol. 77, pp. 50-56, 2015.
-
(2015)
Bone
, vol.77
, pp. 50-56
-
-
Newman, C.L.1
Chen, N.X.2
Smith, E.3
-
115
-
-
84927656291
-
Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097
-
part 4
-
V. Boschert, E.-M. Muth, A. Knappik, C. Frisch, and T. D. Mueller, "Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097, " Acta Crystallographica Section F: Structural Biology Communications, vol. 71, part 4, pp. 388-392, 2015.
-
(2015)
Acta Crystallographica Section F: Structural Biology Communications
, vol.71
, pp. 388-392
-
-
Boschert, V.1
Muth, E.-M.2
Knappik, A.3
Frisch, C.4
Mueller, T.D.5
-
116
-
-
84901228538
-
Expression of sclerostin scFv and the effect of sclerostin scFv on healing of osteoporotic femur fracture in rats
-
Q. Yao, J. Ni, Y. Hou, L. Ding, L. Zhang, and H. Jiang, "Expression of sclerostin scFv and the effect of sclerostin scFv on healing of osteoporotic femur fracture in rats, " Cell Biochemistry and Biophysics, vol. 69, no. 2, pp. 229-235, 2014.
-
(2014)
Cell Biochemistry and Biophysics
, vol.69
, Issue.2
, pp. 229-235
-
-
Yao, Q.1
Ni, J.2
Hou, Y.3
Ding, L.4
Zhang, L.5
Jiang, H.6
-
118
-
-
28744432803
-
Bone mineral density in sclerosteosis; Affected individuals and gene carriers
-
J. C. Gardner, R. L. van Bezooijen, B. Mervis et al., "Bone mineral density in sclerosteosis; affected individuals and gene carriers, " The Journal of Clinical Endocrinology andMetabolism, vol. 90, no. 12, pp. 6392-6395, 2005.
-
(2005)
The Journal of Clinical Endocrinology AndMetabolism
, vol.90
, Issue.12
, pp. 6392-6395
-
-
Gardner, J.C.1
Van Bezooijen, R.L.2
Mervis, B.3
-
119
-
-
4344584730
-
WNT and-catenin signalling: Diseases and therapies
-
R. T. Moon, A. D. Kohn, G. V. De Ferrari, and A. Kaykas, "WNT and-catenin signalling: diseases and therapies, " Nature Reviews Genetics, vol. 5, no. 9, pp. 691-701, 2004.
-
(2004)
Nature Reviews Genetics
, vol.5
, Issue.9
, pp. 691-701
-
-
Moon, R.T.1
Kohn, A.D.2
De Ferrari, G.V.3
Kaykas, A.4
-
120
-
-
84861986053
-
Wnt/-catenin signaling and disease
-
H. Clevers and R. Nusse, "Wnt/-catenin signaling and disease, " Cell, vol. 149, no. 6, pp. 1192-1205, 2012.
-
(2012)
Cell
, vol.149
, Issue.6
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
121
-
-
84903767326
-
Can we safely target the WNT pathwaY
-
M. Kahn, "Can we safely target the WNT pathwaY" Nature Reviews Drug Discovery, vol. 13, no. 7, pp. 513-532, 2014.
-
(2014)
Nature Reviews Drug Discovery
, vol.13
, Issue.7
, pp. 513-532
-
-
Kahn, M.1
-
122
-
-
84884191372
-
Effects of constitutive-catenin activation on vertebral bone growth and remodeling at different postnatal stages in mice
-
M. Jia, S. Chen, B. Zhang et al., "Effects of constitutive-catenin activation on vertebral bone growth and remodeling at different postnatal stages in mice, " PLoS ONE, vol. 8, no. 9, Article ID e74093, 2013.
-
(2013)
PLoS ONE
, vol.8
, Issue.9
-
-
Jia, M.1
Chen, S.2
Zhang, B.3
-
123
-
-
84931828687
-
Adverse effects of osteocytic constitutive activation of ß-catenin on bone strength and bone growth
-
S. Chen, J. Feng, Q. Bao et al., "Adverse effects of osteocytic constitutive activation of ß-catenin on bone strength and bone growth, " Journal of Bone andMineral Research, vol. 30, no. 7, pp. 1184-1194, 2015.
-
(2015)
Journal of Bone AndMineral Research
, vol.30
, Issue.7
, pp. 1184-1194
-
-
Chen, S.1
Feng, J.2
Bao, Q.3
-
124
-
-
84856783815
-
Updateonbone anabolics inosteoporosis treatment: Rationale, current status, and perspectives
-
R. BaronandE. Hesse, "Updateonbone anabolics inosteoporosis treatment: rationale, current status, and perspectives, " The Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 2, pp. 311-325, 2012.
-
(2012)
The Journal of Clinical Endocrinology and Metabolism
, vol.97
, Issue.2
, pp. 311-325
-
-
Baron, R.1
Hesse, E.2
-
125
-
-
84905673488
-
Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats
-
M. Stolina, D. Dwyer, Q.-T. Niu et al., "Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats, " Bone, vol. 67, pp. 305-313, 2014.
-
(2014)
Bone
, vol.67
, pp. 305-313
-
-
Stolina, M.1
Dwyer, D.2
Niu, Q.-T.3
|