Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats

Journal of Orthopaedic Research

Volumn 30, Issue 10, 2012, Pages 1541-1548

  McDonald, Michelle M ^a   Morse, Alyson ^a   Mikulec, Kathy ^a   Peacock, Lauren ^a   Yu, Nicole ^a   Baldock, Paul A ^b   Birke, Oliver ^a   Liu, Min ^c   Ke, Hua Zhu ^c   Little, David G ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c AMGEN INC   (United States)

Author keywords

bone; defect; formation; repair; sclerostin

Indexed keywords

PROTEIN ANTIBODY; SCLEROSTIN; SCLEROSTIN ANTIBODY; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; BONE DENSITY; BONE REMODELING; BONE TURNOVER; CONTROLLED STUDY; FEMALE; FLUOROCHROME STAINING; FRACTURE HEALING; HISTOLOGY; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; PROXIMAL TIBIA FRACTURE; RAT; SYSTEMIC THERAPY; TREATMENT DURATION;

ANIMALS; ANTIBODIES; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE RESORPTION; FEMALE; FRACTURE HEALING; GENETIC MARKERS; OSTEOGENESIS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; X-RAY MICROTOMOGRAPHY;

EID: 84865509876     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22109     Document Type: Article

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