Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 24, 2016, Pages E3441-E3450

  Grace, Peter M ^a,b   Strand, Keith A ^a   Galer, Erika L ^a   Urban, Daniel J ^c   Wang, Xiaohui ^a,d   Baratta, Michael V ^a   Fabisiak, Timothy J ^a   Anderson, Nathan D ^a   Cheng, Kejun ^e   Greene, Lisa I ^a   Berkelhammer, Debra ^a   Zhang, Yingning ^a   Ellis, Amanda L ^a   Yin, Hang Hubert ^a,f   Campeau, Serge ^a   Ricei, Kenner C ^e   Roth, Bryan L ^c   Maier, Steven F ^a   Watkins, Linda R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^e NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^f TSINGHUA UNIVERSITY   (China)

Author keywords

DAMP; Danger signals; Opioid induced hyperalgesia; P2X7R; TLR4

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MORPHINE; CLOZAPINE; CLOZAPINE N-OXIDE; IL1B PROTEIN, RAT; NLRP3 PROTEIN, RAT;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC CONSTRICTION INJURY; CHRONIC PAIN; CONTROLLED STUDY; DRUG SENSITIZATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; MALE; MICROGLIA; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD DORSAL HORN; ANALOGS AND DERIVATIVES; ANIMAL; FISCHER 344 RAT; METABOLISM; NEURALGIA; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CHRONIC PAIN; CLOZAPINE; INFLAMMASOMES; INTERLEUKIN-1BETA; MALE; MICROGLIA; MORPHINE; NEURALGIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SPINAL CORD DORSAL HORN;

EID: 84974686692     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602070113     Document Type: Article

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