Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

Pain

Volumn 155, Issue 9, 2014, Pages 1802-1813

  Agalave, Nilesh M ^a   Larsson, Max ^a,b   Abdelmoaty, Sally ^a   Su, Jie ^a   Baharpoor, Azar ^a   Lundbäck, Peter ^a   Palmblad, Karin ^a   Andersson, Ulf ^a   Harris, Helena ^a   Svensson, Camilla I ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Cytokine; HMGB1; Hypersensitivity; Inflammation; Pain; Rheumatoid arthritis; Spinal cord; TLR4

Indexed keywords

COLLAGEN ANTIBODY; HIGH MOBILITY GROUP B1 PROTEIN; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL ARTHRITIS; FEMALE; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; GLIA; HYPERALGESIA; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL CORD;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BEHAVIOR, ANIMAL; FEMALE; HMGB1 PROTEIN; HYPERALGESIA; MALE; MICE; NEUROGLIA; SPINAL CORD; TOLL-LIKE RECEPTOR 4;

EID: 84926416315     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.06.007     Document Type: Article

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