The poly(ADP-ribose) polymerase enzyme Tankyrase antagonizes activity of the β-catenin destruction complex through ADP-ribosylation of Axin and APC2

Journal of Biological Chemistry

Volumn 291, Issue 24, 2016, Pages 12747-12760

  Croy, Heather E ^a   Fuller, Caitlyn N ^a   Giannotti, Jemma ^a   Robinson, Paige ^a   Foley, Andrew V A ^a   Yamulla, Robert J ^a   Cosgriff, Sean ^a   Greaves, Bradford D ^a   Von Kleeck, Ryan A ^a   An, Hyun Hyung ^a   Powers, Catherine M ^a   Tran, Julie K ^a   Tocker, Aaron M ^a   Jacob, Kimberly D ^a   Davis, Beckley K ^a   Roberts, David M ^a  

^a FRANKLIN AND MARSHALL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELL SIGNALING; DISEASES; ENZYME ACTIVITY; ENZYMES; ONCOLOGY; PROTEINS; PROTEOLYSIS; SCAFFOLDS (BIOLOGY);

ADENOMATOUS POLYPOSIS COLI; COLON CANCER CELLS; COMPLEX REGULATION; NEGATIVE REGULATORS; POLY(ADP-RIBOSE) POLYMERASE; TUMOR SUPPRESSORS; UBIQUITIN-MEDIATED PROTEOLYSIS; WNT SIGNALING PATHWAYS;

ENZYME INHIBITION;

7,8 DIHYDRO 2 [4 (TRIFLUOROMETHYL)PHENYL] 5H THIOPYRANO[4,3 D]PYRIMIDIN 4 OL; APC PROTEIN; APC2 PROTEIN; AXIN; BETA CATENIN; TANKYRASE; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE RIBOSE; APC2 PROTEIN, DROSOPHILA; APC2 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DROSOPHILA PROTEIN; PROTEIN BINDING; TNKS PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL EXPERIMENT; APC2 GENE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DNA BINDING MOTIF; DROSOPHILA MELANOGASTER; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SUBSTRATE COMPLEX; FEMALE; GENE DELETION; GENETIC TRANSFECTION; HUMAN; MALE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SW480 CELL LINE; TRANSGENE; TWO HYBRID SYSTEM; UBIQUITINATION; WNT SIGNALING PATHWAY; AMINO ACID SEQUENCE; ANIMAL; DROSOPHILA; ENZYME SPECIFICITY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HCT 116 CELL LINE; METABOLISM; TRANSGENIC ANIMAL; TUMOR CELL LINE; WESTERN BLOTTING;

ADENOSINE DIPHOSPHATE RIBOSE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXIN PROTEIN; BETA CATENIN; BLOTTING, WESTERN; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HCT116 CELLS; HUMANS; MALE; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TANKYRASES; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84974530738     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.705442     Document Type: Article

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