HectDI E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 3753-3767

  Tran, Hoanh ^a   Bustos, Daisy ^a   Yeh, Ronald ^a   Rubinfeld, Bonnee ^a   Lam, Cynthia ^a   Shriver, Stephanie ^a   Zilberleyb, Inna ^a   Lee, Michelle W ^a   Phu, Lilian ^a   Sarkar, Anjali A ^b   Zohn, Irene E ^b   Wertz, Ingrid E ^a   Kirkpatrick, Donald S ^a   Polakis, Paul ^a  

^a GENENTECH INC   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYPOSIS COLI; E3 LIGASE; NEGATIVE REGULATORS; POLYUBIQUITIN; POLYUBIQUITYLATION; PROTEIN FUNCTIONS; UBIQUITIN LIGASES; UBIQUITYLATION; WNT SIGNALING; WNT SIGNALING PATHWAYS;

BIOCHEMISTRY; BIOLOGY;

PHOSPHORYLATION;

APC PROTEIN; AXIN; BETA CATENIN; POLYUBIQUITIN; PROTEIN HECTD1; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WNT3A PROTEIN; APC PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; GENE SILENCING; INTRACELLULAR SIGNALING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION; WNT SIGNALING PATHWAY; ANIMAL; CELL STRAIN HEK293; GENETICS; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN BINDING;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; AXIN PROTEIN; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MICE; POLYUBIQUITIN; PROTEIN BINDING; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; WNT SIGNALING PATHWAY;

MLCS; MLOWN;

EID: 84873674014     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.415240     Document Type: Article

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