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Volumn 13, Issue 11, 2015, Pages 1487-1501

Structure, dynamics, and functionality of tankyrase inhibitor-induced degradasomes

Author keywords

[No Author keywords available]

Indexed keywords

B TRANSDUCING REPEAT CONTAINING PROTEIN; BETA CATENIN; CYTOPLASM PROTEIN; G 007LK; MULTIPROTEIN COMPLEX; PROTEIN; TANKYRASE INHIBITOR; UBIQUITIN; UNCLASSIFIED DRUG; AXIN; G007-LK; SULFONE; TANKYRASE; TNKS PROTEIN, HUMAN; TRIAZOLE DERIVATIVE;

EID: 84947079246     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-15-0125     Document Type: Article
Times cited : (36)

References (50)
  • 1
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 2
    • 77950877526 scopus 로고    scopus 로고
    • Wnt signalling and the control of cellular metabolism
    • Sethi JK, Vidal-Puig A. Wnt signalling and the control of cellular metabolism. Biochem J 2010;427:1-17.
    • (2010) Biochem J , vol.427 , pp. 1-17
    • Sethi, J.K.1    Vidal-Puig, A.2
  • 3
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/b-Catenin signaling and disease
    • Clevers H, Nusse R. Wnt/b-Catenin signaling and disease. Cell 2012;149:1192-205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 4
    • 84862171364 scopus 로고    scopus 로고
    • The many faces and functions of b-catenin
    • Valenta T, Hausmann G, Basler K. The many faces and functions of b-catenin. EMBO J 2012;31:2714-36.
    • (2012) EMBO J , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 5
    • 33845351956 scopus 로고    scopus 로고
    • B-catenin destruction complex: Insights and questions from a structural perspective
    • Kimelman D, Xu W. b-catenin destruction complex: insights and questions from a structural perspective. Oncogene 2006;25:7482-91.
    • (2006) Oncogene , vol.25 , pp. 7482-7491
    • Kimelman, D.1    Xu, W.2
  • 6
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/b-Catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X. Wnt/b-Catenin signaling: components, mechanisms, and diseases. Dev Cell 2009;17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 7
    • 81355161240 scopus 로고    scopus 로고
    • Inhibition of GSK3 by Wnt signalling-two contrasting models
    • Metcalfe C, Bienz M. Inhibition of GSK3 by Wnt signalling-two contrasting models. J Cell Sci 2011;124:3537-44.
    • (2011) J Cell Sci , vol.124 , pp. 3537-3544
    • Metcalfe, C.1    Bienz, M.2
  • 8
    • 84861972831 scopus 로고    scopus 로고
    • Wnt signaling through inhibition of b-catenin degradation in an intact Axin1 complex
    • Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, et al. Wnt signaling through inhibition of b-catenin degradation in an intact Axin1 complex. Cell 2012;149:1245-56.
    • (2012) Cell , vol.149 , pp. 1245-1256
    • Li, V.S.1    Ng, S.S.2    Boersema, P.J.3    Low, T.Y.4    Karthaus, W.R.5    Gerlach, J.P.6
  • 9
    • 84911462377 scopus 로고    scopus 로고
    • Tankyrases: Structure, function and therapeutic implications in cancer
    • Haikarainen T, Krauss S, Lehtio L. Tankyrases: structure, function and therapeutic implications in cancer. Curr Pharm Des 2014;20:6472-88.
    • (2014) Curr Pharm des , vol.20 , pp. 6472-6488
    • Haikarainen, T.1    Krauss, S.2    Lehtio, L.3
  • 10
    • 36749045682 scopus 로고    scopus 로고
    • Tankyrase function at telomeres, spindle poles, and beyond
    • Hsiao SJ, Smith S. Tankyrase function at telomeres, spindle poles, and beyond. Biochimie 2008;90:83-92.
    • (2008) Biochimie , vol.90 , pp. 83-92
    • Hsiao, S.J.1    Smith, S.2
  • 12
    • 4243067196 scopus 로고    scopus 로고
    • The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    • Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol 2003;1:e10.
    • (2003) PLoS Biol , vol.1 , pp. e10
    • Lee, E.1    Salic, A.2    Krüger, R.3    Heinrich, R.4    Kirschner, M.W.5
  • 13
    • 84880330905 scopus 로고    scopus 로고
    • Tankyrases as drug targets
    • Lehtiö L, Chi N-W, Krauss S. Tankyrases as drug targets. FEBS J 2013;280:3576-93.
    • (2013) FEBS J , vol.280 , pp. 3576-3593
    • Lehtiö, L.1    Chi, N.-W.2    Krauss, S.3
  • 14
    • 84907677397 scopus 로고    scopus 로고
    • Recent advances in the structure-based rational design of TNKSIs
    • Zhan P, Song YN, Itoh Y, Suzuki T, Liu X. Recent advances in the structure-based rational design of TNKSIs. Mol Bio Syst 2014;10:2783-99.
    • (2014) Mol Bio Syst , vol.10 , pp. 2783-2799
    • Zhan, P.1    Song, Y.N.2    Itoh, Y.3    Suzuki, T.4    Liu, X.5
  • 15
    • 78651385875 scopus 로고    scopus 로고
    • Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth
    • Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res 2011;71:197-205.
    • (2011) Cancer Res , vol.71 , pp. 197-205
    • Waaler, J.1    Machon, O.2    Von Kries, J.P.3    Wilson, S.R.4    Lundenes, E.5    Wedlich, D.6
  • 16
    • 84861843671 scopus 로고    scopus 로고
    • A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
    • Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res 2012;72:2822-32.
    • (2012) Cancer Res , vol.72 , pp. 2822-2832
    • Waaler, J.1    Machon, O.2    Tumova, L.3    Dinh, H.4    Korinek, V.5    Wilson, S.R.6
  • 17
    • 84896500154 scopus 로고    scopus 로고
    • LEF1 and B9L shield b-catenin from inactivation by Axin, desensitizing colorectal cancer cells to Tankyrase inhibitors
    • de la Roche M, Ibrahim AEK, Mieszczanek J, Bienz M. LEF1 and B9L shield b-catenin from inactivation by Axin, desensitizing colorectal cancer cells to Tankyrase inhibitors. Cancer Res 2014;74:1495-505.
    • (2014) Cancer Res , vol.74 , pp. 1495-1505
    • De La Roche, M.1    Ibrahim, A.E.K.2    Mieszczanek, J.3    Bienz, M.4
  • 18
    • 84861699364 scopus 로고    scopus 로고
    • The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
    • Mendoza-Topaz C, Mieszczanek J, Bienz M. The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. Open Biol 2011;1:110013.
    • (2011) Open Biol , vol.1 , pp. 110013
    • Mendoza-Topaz, C.1    Mieszczanek, J.2    Bienz, M.3
  • 19
    • 84876230312 scopus 로고    scopus 로고
    • Structural basis and SAR for G007-LK, a lead stage 1, 2, 4-Triazole based specific Tankyrase 1/2 inhibitor
    • Voronkov A, Holsworth DD, Waaler J, Wilson SR, Ekblad B, Perdreau-Dahl H, et al. Structural basis and SAR for G007-LK, a lead stage 1, 2, 4-Triazole based specific Tankyrase 1/2 inhibitor. J Med Chem 2013;56:3012-23.
    • (2013) J Med Chem , vol.56 , pp. 3012-3023
    • Voronkov, A.1    Holsworth, D.D.2    Waaler, J.3    Wilson, S.R.4    Ekblad, B.5    Perdreau-Dahl, H.6
  • 20
    • 84877720042 scopus 로고    scopus 로고
    • A novel Tankyrase small-molecule inhibitor suppresses APC mutation-drivencolorectal tumor growth
    • Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, et al. A novel Tankyrase small-molecule inhibitor suppresses APC mutation-drivencolorectal tumor growth. Cancer Res 2013;73:3132-44.
    • (2013) Cancer Res , vol.73 , pp. 3132-3144
    • Lau, T.1    Chan, E.2    Callow, M.3    Waaler, J.4    Boggs, J.5    Blake, R.A.6
  • 22
    • 0029030937 scopus 로고
    • EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif
    • Mu FT, Callaghan JM, Steele-Mortimer O, Stenmark H, Parton RG, Campbell PL, et al. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J Biol Chem 1995;270:13503-11.
    • (1995) J Biol Chem , vol.270 , pp. 13503-13511
    • Mu, F.T.1    Callaghan, J.M.2    Steele-Mortimer, O.3    Stenmark, H.4    Parton, R.G.5    Campbell, P.L.6
  • 23
    • 0033638333 scopus 로고    scopus 로고
    • Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins
    • Zhou P, Bogacki R, McReynolds L, Howley PM. Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins. Mol Cell 2000;6:751-56.
    • (2000) Mol Cell , vol.6 , pp. 751-756
    • Zhou, P.1    Bogacki, R.2    McReynolds, L.3    Howley, P.M.4
  • 25
    • 68449083213 scopus 로고    scopus 로고
    • A versatile viral system for expression and depletion of proteins in mammalian cells
    • Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, et al. A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One 2009;4:e6529.
    • (2009) PLoS One , vol.4 , pp. e6529
    • Campeau, E.1    Ruhl, V.E.2    Rodier, F.3    Smith, C.L.4    Rahmberg, B.L.5    Fuss, J.O.6
  • 26
    • 77950510375 scopus 로고    scopus 로고
    • PtdIns (3) P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
    • Sagona AP, Nezis IP, Pedersen NM, Liestol K, Poulton J, Rusten TE, et al. PtdIns (3) P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol 2010;12:362-71.
    • (2010) Nat Cell Biol , vol.12 , pp. 362-371
    • Sagona, A.P.1    Nezis, I.P.2    Pedersen, N.M.3    Liestol, K.4    Poulton, J.5    Rusten, T.E.6
  • 28
    • 84927153784 scopus 로고    scopus 로고
    • Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
    • Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, et al. Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Nature 2015;520:234-38.
    • (2015) Nature , vol.520 , pp. 234-238
    • Raiborg, C.1    Wenzel, E.M.2    Pedersen, N.M.3    Olsvik, H.4    Schink, K.O.5    Schultz, S.W.6
  • 29
    • 0030949463 scopus 로고    scopus 로고
    • Activation of b-Catenin-Tcf signaling in colon cancer by mutations in b-Catenin or APC
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of b-Catenin-Tcf signaling in colon cancer by mutations in b-Catenin or APC. Science 1997;275:1787-90.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6
  • 30
    • 77956551196 scopus 로고    scopus 로고
    • Systematic comparison of constitutive promoters and the Doxycycline-inducible promoter
    • Qin JY, Zhang L, Clift KL, Hulur I, Xiang AP, Ren B-Z, et al. Systematic comparison of constitutive promoters and the Doxycycline-inducible promoter. PLoS ONE 2010;5:e10611.
    • (2010) PLoS ONE , vol.5 , pp. e10611
    • Qin, J.Y.1    Zhang, L.2    Clift, K.L.3    Hulur, I.4    Xiang, A.P.5    Ren, B.-Z.6
  • 33
    • 56849086074 scopus 로고    scopus 로고
    • APC is essential for targeting phosphorylated b-catenin to the SCFb-TrCP ubiquitin ligase
    • Su Y, Fu C, Ishikawa S, Stella A, Kojima M, Shitoh K, et al. APC is essential for targeting phosphorylated b-catenin to the SCFb-TrCP ubiquitin ligase. Mol Cell 2008;32:652-61.
    • (2008) Mol Cell , vol.32 , pp. 652-661
    • Su, Y.1    Fu, C.2    Ishikawa, S.3    Stella, A.4    Kojima, M.5    Shitoh, K.6
  • 34
    • 0033602227 scopus 로고    scopus 로고
    • The F-box protein b-TrCP associates with phosphorylated b-catenin and regulates its activity in the cell
    • Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, et al. The F-box protein b-TrCP associates with phosphorylated b-catenin and regulates its activity in the cell. Curr Biol 1999;9:207-11.
    • (1999) Curr Biol , vol.9 , pp. 207-211
    • Hart, M.1    Concordet, J.P.2    Lassot, I.3    Albert, I.4    Del los Santos, R.5    Durand, H.6
  • 35
    • 12444265752 scopus 로고    scopus 로고
    • Development and applications of a b-catenin oligonucleotide microarray: B-catenin mutations are dominantly found in the proximal colon cancers with microsatellite instability
    • Kim I-J, Kang HC, Park J-H, Shin Y, Ku J-L, Lim S-B, et al. Development and applications of a b-catenin oligonucleotide microarray: b-catenin mutations are dominantly found in the proximal colon cancers with microsatellite instability. Clin Cancer Res 2003;9:2920-5.
    • (2003) Clin Cancer Res , vol.9 , pp. 2920-2925
    • Kim, I.-J.1    Kang, H.C.2    Park, J.-H.3    Shin, Y.4    Ku, J.-L.5    Lim, S.-B.6
  • 36
    • 0034976147 scopus 로고    scopus 로고
    • From fixed to FRAP: Measuring protein mobility and activity in living cells
    • Reits EAJ, Neefjes JJ. From fixed to FRAP: measuring protein mobility and activity in living cells. Nat Cell Biol 2001;3:E145-7.
    • (2001) Nat Cell Biol , vol.3 , pp. E145-E147
    • Reits, E.A.J.1    Neefjes, J.J.2
  • 37
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012;487:330-7.
    • (2012) Nature , vol.487 , pp. 330-337
    • Cancer Genome Atlas Network1
  • 38
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013;13:11-26.
    • (2013) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 39
    • 58249122326 scopus 로고    scopus 로고
    • Small moleculemediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    • Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan C-W, et al. Small moleculemediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009;5:100-7.
    • (2009) Nat Chem Biol , vol.5 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3    Lu, J.4    Ma, Z.5    Fan, C.-W.6
  • 41
    • 84863116261 scopus 로고    scopus 로고
    • [1, 2, 4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1, 2, 4]oxadiazoles: Antagonists of the Wnt pathway that inhibit Tankyrases 1 and 2 via novel adenosine pocket binding
    • Shultz MD, Kirby CA, Stams T, Chin DN, Blank J, Charlat O, et al. [1, 2, 4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1, 2, 4]oxadiazoles: antagonists of the Wnt pathway that inhibit Tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem 2012;55:1127-36.
    • (2012) J Med Chem , vol.55 , pp. 1127-1136
    • Shultz, M.D.1    Kirby, C.A.2    Stams, T.3    Chin, D.N.4    Blank, J.5    Charlat, O.6
  • 42
    • 79960727271 scopus 로고    scopus 로고
    • Ubiquitinligase RNF146 regulates Tankyrase and Axintopromote Wnt signaling
    • Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, etal. Ubiquitinligase RNF146 regulates Tankyrase and Axintopromote Wnt signaling. PLoS One 2011;6:e22595.
    • (2011) PLoS One , vol.6 , pp. e22595
    • Callow, M.G.1    Tran, H.2    Phu, L.3    Lau, T.4    Lee, J.5    Sandoval, W.N.6
  • 43
    • 79955617241 scopus 로고    scopus 로고
    • RNF146 is a poly (ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
    • Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, et al. RNF146 is a poly (ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol 2011;13:623-9.
    • (2011) Nat Cell Biol , vol.13 , pp. 623-629
    • Zhang, Y.1    Liu, S.2    Mickanin, C.3    Feng, Y.4    Charlat, O.5    Michaud, G.A.6
  • 44
    • 33750562735 scopus 로고    scopus 로고
    • Tankyrase recruitment to the lateral membrane in polarized epithelial cells: Regulation by cell-cell contact and protein poly (ADP-ribosyl) ation
    • Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW. Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly (ADP-ribosyl) ation. Biochem J 2006;399:415-25.
    • (2006) Biochem J , vol.399 , pp. 415-425
    • Yeh, T.Y.1    Meyer, T.N.2    Schwesinger, C.3    Tsun, Z.Y.4    Lee, R.M.5    Chi, N.W.6
  • 45
    • 29244462476 scopus 로고    scopus 로고
    • The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
    • Schwarz-Romond T, Merrifield C, Nichols BJ, Bienz M. The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J Cell Sci 2005;118:5269-77.
    • (2005) J Cell Sci , vol.118 , pp. 5269-5277
    • Schwarz-Romond, T.1    Merrifield, C.2    Nichols, B.J.3    Bienz, M.4
  • 46
    • 34547750005 scopus 로고    scopus 로고
    • Dynamic recruitment of axin by Dishevelled protein assemblies
    • Schwarz-Romond T, Metcalfe C, Bienz M. Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci 2007;120:2402-12.
    • (2007) J Cell Sci , vol.120 , pp. 2402-2412
    • Schwarz-Romond, T.1    Metcalfe, C.2    Bienz, M.3
  • 47
    • 0028987249 scopus 로고
    • Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 1995;92:3046-50.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3046-3050
    • Munemitsu, S.1    Albert, I.2    Souza, B.3    Rubinfeld, B.4    Polakis, P.5
  • 48
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an Axin homolog, Conductin, with b-catenin, APC, and GSK3b
    • Behrens J, Jerchow B-A, Würtele M, Grimm J, Asbrand C, Wirtz R, et al. Functional interaction of an Axin homolog, Conductin, with b-catenin, APC, and GSK3b. Science 1998;280:596-9.
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1    Jerchow, B.-A.2    Würtele, M.3    Grimm, J.4    Asbrand, C.5    Wirtz, R.6
  • 50
    • 7644226406 scopus 로고    scopus 로고
    • Tankyrase polymerization iscontrolledbyits sterile alpha motif and poly (ADP-ribose) polymerase domains
    • De Rycker M, Price CM. Tankyrase polymerization iscontrolledbyits sterile alpha motif and poly (ADP-ribose) polymerase domains. Mol Cell Biol 2004;24:9802-12.
    • (2004) Mol Cell Biol , vol.24 , pp. 9802-9812
    • De Rycker, M.1    Price, C.M.2


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