메뉴 건너뛰기




Volumn , Issue , 2016, Pages 17-25

Peroxisome Proliferator-Activated Receptor Ligands and Their Role in Chronic Myeloid Leukemia: Therapeutic Strategies

Author keywords

cancer; chemotherapy; chronic myeloid leukemia; peroxisome proliferator activated receptors

Indexed keywords

IMATINIB; LIGAND; ORGANIC CATION TRANSPORTER 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR LIGAND; UNCLASSIFIED DRUG;

EID: 84973922761     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12737     Document Type: Review
Times cited : (39)

References (91)
  • 1
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists
    • Grommes C., Landreth G.E., Heneka M.T. (2004) Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists. Lancet Oncol;5:419–429.
    • (2004) Lancet Oncol , vol.5 , pp. 419-429
    • Grommes, C.1    Landreth, G.E.2    Heneka, M.T.3
  • 2
    • 84908143823 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-beta/delta (PPAR-beta/delta) inhibits human breast cancer cell line tumorigenicity
    • Yao P.L., Morales J.L., Zhu B., Kang B.H., Gonzalez F.J., Peters J.M. (2014) Activation of peroxisome proliferator-activated receptor-beta/delta (PPAR-beta/delta) inhibits human breast cancer cell line tumorigenicity. Mol Cancer Ther;13:1008–1017.
    • (2014) Mol Cancer Ther , vol.13 , pp. 1008-1017
    • Yao, P.L.1    Morales, J.L.2    Zhu, B.3    Kang, B.H.4    Gonzalez, F.J.5    Peters, J.M.6
  • 4
    • 68849097535 scopus 로고    scopus 로고
    • All-trans retinoic acid can intensify the growth inhibition and differentiation induction effect of rosiglitazone on multiple myeloma cells
    • Huang H., Wu D., Fu J., Chen G., Chang W., Chow H.C., Leung A.Y., Liang R. (2009) All-trans retinoic acid can intensify the growth inhibition and differentiation induction effect of rosiglitazone on multiple myeloma cells. Eur J Haematol;83:191–202.
    • (2009) Eur J Haematol , vol.83 , pp. 191-202
    • Huang, H.1    Wu, D.2    Fu, J.3    Chen, G.4    Chang, W.5    Chow, H.C.6    Leung, A.Y.7    Liang, R.8
  • 5
    • 10744219838 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia
    • Zang C., Liu H., Posch M.G., Waechter M., Facklam M., Fenner M.H., Ruthardt M. (2004) Peroxisome proliferator-activated receptor γ ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. Leuk Res;28:387–397.
    • (2004) Leuk Res , vol.28 , pp. 387-397
    • Zang, C.1    Liu, H.2    Posch, M.G.3    Waechter, M.4    Facklam, M.5    Fenner, M.H.6    Ruthardt, M.7
  • 7
    • 7044222416 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Daley G.Q. (2004) Chronic myeloid leukemia. Cell;119:314–316.
    • (2004) Cell , vol.119 , pp. 314-316
    • Daley, G.Q.1
  • 8
    • 60749136424 scopus 로고    scopus 로고
    • Targeted drugs in chronic myeloid leukemia
    • Gora-Tybor J., Robak T. (2008) Targeted drugs in chronic myeloid leukemia. Curr Med Chem;15:3036–3051.
    • (2008) Curr Med Chem , vol.15 , pp. 3036-3051
    • Gora-Tybor, J.1    Robak, T.2
  • 10
    • 0041887308 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation
    • Blanquart C., Barbier O., Fruchart J.C., Staels B., Glineur C. (2003) Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol;85:267–273.
    • (2003) J Steroid Biochem Mol Biol , vol.85 , pp. 267-273
    • Blanquart, C.1    Barbier, O.2    Fruchart, J.C.3    Staels, B.4    Glineur, C.5
  • 14
    • 84875297293 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor a ligands as anticancer drugs targeting mitochondrial metabolism
    • Grabacka M., Pierzchalska M., Reiss K. (2013) Peroxisome proliferator activated receptor a ligands as anticancer drugs targeting mitochondrial metabolism. Curr Pharm Biotechnol;14:342.
    • (2013) Curr Pharm Biotechnol , vol.14 , pp. 342
    • Grabacka, M.1    Pierzchalska, M.2    Reiss, K.3
  • 15
    • 3242784885 scopus 로고    scopus 로고
    • Mechanism of the nuclear receptor molecular switch
    • Nagy L., Schwabe J.W. (2004) Mechanism of the nuclear receptor molecular switch. Trends Biochem Sci;29:317–324.
    • (2004) Trends Biochem Sci , vol.29 , pp. 317-324
    • Nagy, L.1    Schwabe, J.W.2
  • 16
    • 0031030718 scopus 로고    scopus 로고
    • Ligand-induced peroxisome proliferator-activated receptor alpha conformational change
    • Dowell P., Peterson V.J., Zabriskie T.M., Leid M. (1997) Ligand-induced peroxisome proliferator-activated receptor alpha conformational change. J Biol Chem;272:2013–2020.
    • (1997) J Biol Chem , vol.272 , pp. 2013-2020
    • Dowell, P.1    Peterson, V.J.2    Zabriskie, T.M.3    Leid, M.4
  • 17
    • 33646524699 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and inflammation
    • Moraes L.A., Piqueras L., Bishop-Bailey D. (2006) Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther;110:371–385.
    • (2006) Pharmacol Ther , vol.110 , pp. 371-385
    • Moraes, L.A.1    Piqueras, L.2    Bishop-Bailey, D.3
  • 18
    • 0037389926 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: a critical review on endogenous pathways for ligand generation
    • Bishop-Bailey D., Wray J. (2003) Peroxisome proliferator-activated receptors: a critical review on endogenous pathways for ligand generation. Prostaglandins Other Lipid Mediat;71:1–22.
    • (2003) Prostaglandins Other Lipid Mediat , vol.71 , pp. 1-22
    • Bishop-Bailey, D.1    Wray, J.2
  • 24
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Järvinen H. (2004) Thiazolidinediones. N Engl J Med;351:1106–1118.
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Järvinen, H.1
  • 25
    • 71949101616 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) but not PPARα serves as a plasma free fatty acid sensor in liver
    • Sanderson L.M., Degenhardt T., Koppen A., Kalkhoven E., Desvergne B., Müller M., Kersten S. (2009) Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) but not PPARα serves as a plasma free fatty acid sensor in liver. Mol Cell Biol;29:6257–6267.
    • (2009) Mol Cell Biol , vol.29 , pp. 6257-6267
    • Sanderson, L.M.1    Degenhardt, T.2    Koppen, A.3    Kalkhoven, E.4    Desvergne, B.5    Müller, M.6    Kersten, S.7
  • 29
    • 0347753697 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptors and cancers: complex stories
    • Michalik L., Desvergne B., Wahli W. (2004) Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat Rev Cancer;4:61–70.
    • (2004) Nat Rev Cancer , vol.4 , pp. 61-70
    • Michalik, L.1    Desvergne, B.2    Wahli, W.3
  • 31
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I., Green S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature;347:645–650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 33
    • 0033832034 scopus 로고    scopus 로고
    • Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARα activators restores tissue homeostasis
    • Kömüves L.G., Hanley K., Man M.-Q., Elias P.M., Williams M.L., Feingold K.R. (2000) Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARα activators restores tissue homeostasis. J Invest Dermatol;115:361–367.
    • (2000) J Invest Dermatol , vol.115 , pp. 361-367
    • Kömüves, L.G.1    Hanley, K.2    Man, M.-Q.3    Elias, P.M.4    Williams, M.L.5    Feingold, K.R.6
  • 35
    • 44249122635 scopus 로고    scopus 로고
    • PPAR ligands for cancer chemoprevention
    • Yasui Y., Kim M., Tanaka T. (2008) PPAR ligands for cancer chemoprevention. PPAR Res;2008:548919. doi: 10.1155/2008/548919.
    • (2008) PPAR Res , vol.2008 , pp. 548919
    • Yasui, Y.1    Kim, M.2    Tanaka, T.3
  • 36
    • 0033889189 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α is an androgen-responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma
    • Collett G.P., Betts A.M., Johnson M.I., Pulimood A.B., Cook S., Neal D.E., Robson C.N. (2000) Peroxisome proliferator-activated receptor α is an androgen-responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma. Clin Cancer Res;6:3241–3248.
    • (2000) Clin Cancer Res , vol.6 , pp. 3241-3248
    • Collett, G.P.1    Betts, A.M.2    Johnson, M.I.3    Pulimood, A.B.4    Cook, S.5    Neal, D.E.6    Robson, C.N.7
  • 37
    • 33745103705 scopus 로고    scopus 로고
    • In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer
    • Saidi S.A., Holland C.M., Charnock-Jones D.S., Smith S.K. (2006) In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer. Mol Cancer;5:13.
    • (2006) Mol Cancer , vol.5 , pp. 13
    • Saidi, S.A.1    Holland, C.M.2    Charnock-Jones, D.S.3    Smith, S.K.4
  • 39
    • 0035866756 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in Rats1
    • Tanaka T., Kohno H., Yoshitani S.-I., Takashima S., Okumura A., Murakami A., Hosokawa M. (2001) Ligands for peroxisome proliferator-activated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in Rats1. Cancer Res;61:2424–2428.
    • (2001) Cancer Res , vol.61 , pp. 2424-2428
    • Tanaka, T.1    Kohno, H.2    Yoshitani, S.-I.3    Takashima, S.4    Okumura, A.5    Murakami, A.6    Hosokawa, M.7
  • 40
    • 34547104596 scopus 로고    scopus 로고
    • The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic
    • Scatena R., Bottoni P., Botta G., Martorana G.E., Giardina B. (2007) The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic. Am J Physiol Cell Physiol;293:C12–C21.
    • (2007) Am J Physiol Cell Physiol , vol.293 , pp. C12-C21
    • Scatena, R.1    Bottoni, P.2    Botta, G.3    Martorana, G.E.4    Giardina, B.5
  • 42
    • 35448982383 scopus 로고    scopus 로고
    • Biology of PPARγ in cancer: a critical review on existing lacunae
    • Krishnan A., Nair S.A., Pillai M.R. (2007) Biology of PPARγ in cancer: a critical review on existing lacunae. Curr Mol Med;7:532–540.
    • (2007) Curr Mol Med , vol.7 , pp. 532-540
    • Krishnan, A.1    Nair, S.A.2    Pillai, M.R.3
  • 44
    • 1542313738 scopus 로고    scopus 로고
    • Induction of differentiation and peroxisome proliferator-activated receptor γ expression in colon cancer cell lines by troglitazone
    • Kato M., Kusumi T., Tsuchida S., Tanaka M., Sasaki M., Kudo H. (2004) Induction of differentiation and peroxisome proliferator-activated receptor γ expression in colon cancer cell lines by troglitazone. J Cancer Res Clin Oncol;130:73–79.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 73-79
    • Kato, M.1    Kusumi, T.2    Tsuchida, S.3    Tanaka, M.4    Sasaki, M.5    Kudo, H.6
  • 45
    • 0037899628 scopus 로고    scopus 로고
    • Use of the peroxisome proliferator-activated receptor (PPAR) γ ligand troglitazone as treatment for refractory breast cancer: a phase II study
    • Burstein H.J., Demetri G.D., Mueller E., Sarraf P., Spiegelman B.M., Winer E.P. (2003) Use of the peroxisome proliferator-activated receptor (PPAR) γ ligand troglitazone as treatment for refractory breast cancer: a phase II study. Breast Cancer Res Treat;79:391–397.
    • (2003) Breast Cancer Res Treat , vol.79 , pp. 391-397
    • Burstein, H.J.1    Demetri, G.D.2    Mueller, E.3    Sarraf, P.4    Spiegelman, B.M.5    Winer, E.P.6
  • 46
    • 84903303562 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma agonist rosiglitazone inhibits migration and invasion of prostate cancer cells through inhibition of the CXCR4/CXCL12 axis
    • Qin L., Gong C., Chen A.M., Guo F.J., Xu F., Ren Y., Liao H. (2014) Peroxisome proliferatoractivated receptor gamma agonist rosiglitazone inhibits migration and invasion of prostate cancer cells through inhibition of the CXCR4/CXCL12 axis. Mol Med Rep;10:695–700.
    • (2014) Mol Med Rep , vol.10 , pp. 695-700
    • Qin, L.1    Gong, C.2    Chen, A.M.3    Guo, F.J.4    Xu, F.5    Ren, Y.6    Liao, H.7
  • 47
    • 84900894282 scopus 로고    scopus 로고
    • The PPARgamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells
    • Yan S., Yang X., Chen T., Xi Z., Jiang X. (2014) The PPARgamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Cancer Gene Ther;21:188–193.
    • (2014) Cancer Gene Ther , vol.21 , pp. 188-193
    • Yan, S.1    Yang, X.2    Chen, T.3    Xi, Z.4    Jiang, X.5
  • 49
    • 10744231241 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator activated receptor γ ligands on growth and gene expression profiles of gastric cancer cells
    • Leung W., Bai A., Chan V., Yu J., Chan M., To K., Wu J. (2004) Effect of peroxisome proliferator activated receptor γ ligands on growth and gene expression profiles of gastric cancer cells. Gut;53:331–338.
    • (2004) Gut , vol.53 , pp. 331-338
    • Leung, W.1    Bai, A.2    Chan, V.3    Yu, J.4    Chan, M.5    To, K.6    Wu, J.7
  • 50
    • 0035497756 scopus 로고    scopus 로고
    • PPARγ agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells
    • Kitamura S., Miyazaki Y., Hiraoka S., Nagasawa Y., Toyota M., Takakura R., Kiyohara T. (2001) PPARγ agonists inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells. Int J Cancer;94:335–342.
    • (2001) Int J Cancer , vol.94 , pp. 335-342
    • Kitamura, S.1    Miyazaki, Y.2    Hiraoka, S.3    Nagasawa, Y.4    Toyota, M.5    Takakura, R.6    Kiyohara, T.7
  • 52
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner E., Müller C., Koshizuka K., Williamson E.A., Park D., Asou H., Shintaku P. (1998) Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA;95:8806–8811.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8806-8811
    • Elstner, E.1    Müller, C.2    Koshizuka, K.3    Williamson, E.A.4    Park, D.5    Asou, H.6    Shintaku, P.7
  • 53
    • 0036014980 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-γ in hematologic malignancies
    • Konopleva M., Andreeff M. (2002) Role of peroxisome proliferator-activated receptor-γ in hematologic malignancies. Curr Opin Hematol;9:294–302.
    • (2002) Curr Opin Hematol , vol.9 , pp. 294-302
    • Konopleva, M.1    Andreeff, M.2
  • 54
    • 85047698730 scopus 로고    scopus 로고
    • Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity
    • Yamakawa-Karakida N., Sugita K., Inukai T., Goi K., Nakamura M., Uno K., Sato H. (2002) Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity. Cell Death Differ;9:513–526.
    • (2002) Cell Death Differ , vol.9 , pp. 513-526
    • Yamakawa-Karakida, N.1    Sugita, K.2    Inukai, T.3    Goi, K.4    Nakamura, M.5    Uno, K.6    Sato, H.7
  • 55
    • 33645283642 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells
    • Yasugi E., Horiuchi A., Uemura I., Okuma E., Nakatsu M., Saeki K., Kamisaka Y. (2006) Peroxisome proliferator-activated receptor γ ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. Dev Growth Differ;48:177–188.
    • (2006) Dev Growth Differ , vol.48 , pp. 177-188
    • Yasugi, E.1    Horiuchi, A.2    Uemura, I.3    Okuma, E.4    Nakatsu, M.5    Saeki, K.6    Kamisaka, Y.7
  • 56
    • 33745798598 scopus 로고    scopus 로고
    • Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis
    • Schlezinger J.J., Emberley J.K., Sherr D.H. (2006) Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci;92:433–444.
    • (2006) Toxicol Sci , vol.92 , pp. 433-444
    • Schlezinger, J.J.1    Emberley, J.K.2    Sherr, D.H.3
  • 57
    • 33846651029 scopus 로고    scopus 로고
    • Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-γ agonists induced apoptosis in human monocyte leukemia cells in vitro
    • Liu J.-J., Liu P.-Q., Lin D.-J., Xiao R.-Z., Huang M., Li X.-D., He Y. (2007) Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-γ agonists induced apoptosis in human monocyte leukemia cells in vitro. Ann Hematol;86:173–183.
    • (2007) Ann Hematol , vol.86 , pp. 173-183
    • Liu, J.-J.1    Liu, P.-Q.2    Lin, D.-J.3    Xiao, R.-Z.4    Huang, M.5    Li, X.-D.6    He, Y.7
  • 58
    • 34247554294 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells
    • Lee Y.-R., Yu H.-N., Noh E.-M., Kim J.-S., Song E.-K., Han M.-K., Kim B.-S. (2007) Peroxisome proliferator-activated receptor γ and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells. Int J Hematol;85:231–237.
    • (2007) Int J Hematol , vol.85 , pp. 231-237
    • Lee, Y.-R.1    Yu, H.-N.2    Noh, E.-M.3    Kim, J.-S.4    Song, E.-K.5    Han, M.-K.6    Kim, B.-S.7
  • 59
    • 77957241136 scopus 로고    scopus 로고
    • Anticancer role of PPAR γ agonists in hematological malignancies found in the vasculature, marrow, and eyes
    • Simpson-Haidaris P., Pollock S., Ramon S., Guo N., Woeller C., Feldon S., Phipps R. (2010) Anticancer role of PPAR γ agonists in hematological malignancies found in the vasculature, marrow, and eyes. PPAR Res;2010:814609. doi: 10.1155/2010/814609.
    • (2010) PPAR Res , vol.2010 , pp. 814609
    • Simpson-Haidaris, P.1    Pollock, S.2    Ramon, S.3    Guo, N.4    Woeller, C.5    Feldon, S.6    Phipps, R.7
  • 62
    • 0033544955 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures
    • Basu-Modak S., Braissant O., Escher P., Desvergne B., Honegger P., Wahli W. (1999) Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. J Biol Chem;274:35881–35888.
    • (1999) J Biol Chem , vol.274 , pp. 35881-35888
    • Basu-Modak, S.1    Braissant, O.2    Escher, P.3    Desvergne, B.4    Honegger, P.5    Wahli, W.6
  • 63
    • 0032030951 scopus 로고    scopus 로고
    • Member of the peroxisome proliferator-activated receptor family of transcription factors is differentially expressed by oligodendrocytes
    • Granneman J., Skoff R., Yang X. (1998) Member of the peroxisome proliferator-activated receptor family of transcription factors is differentially expressed by oligodendrocytes. J Neurosci Res;51:563–573.
    • (1998) J Neurosci Res , vol.51 , pp. 563-573
    • Granneman, J.1    Skoff, R.2    Yang, X.3
  • 65
    • 0033695265 scopus 로고    scopus 로고
    • Emerging concepts in metabolic abnormalities associated with coronary artery disease
    • Plutzky J. (2000) Emerging concepts in metabolic abnormalities associated with coronary artery disease. Curr Opin Cardiol;15:416–421.
    • (2000) Curr Opin Cardiol , vol.15 , pp. 416-421
    • Plutzky, J.1
  • 66
    • 4644363465 scopus 로고    scopus 로고
    • A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands
    • Crowe D.L., Chandraratna R. (2004) A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. Breast Cancer Res;6:R546–R555.
    • (2004) Breast Cancer Res , vol.6 , pp. R546-R555
    • Crowe, D.L.1    Chandraratna, R.2
  • 67
    • 17044375811 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors
    • Strakova N., Ehrmann J., Bartos J., Malikova J., Dolezel J., Kolar Z. (2004) Peroxisome proliferator-activated receptors (PPAR) agonists affect cell viability, apoptosis and expression of cell cycle related proteins in cell lines of glial brain tumors. Neoplasma;52:126–136.
    • (2004) Neoplasma , vol.52 , pp. 126-136
    • Strakova, N.1    Ehrmann, J.2    Bartos, J.3    Malikova, J.4    Dolezel, J.5    Kolar, Z.6
  • 70
    • 0034004952 scopus 로고    scopus 로고
    • Thiazolidinedione suppresses the expression of erythroid phenotype in erythroleukemia cell line K562
    • Hirase N., Yanase T., Mu Y.-M., Muta K., Umemura T., Takayanagi R., Nawata H. (2000) Thiazolidinedione suppresses the expression of erythroid phenotype in erythroleukemia cell line K562. Leuk Res;24:393–400.
    • (2000) Leuk Res , vol.24 , pp. 393-400
    • Hirase, N.1    Yanase, T.2    Mu, Y.-M.3    Muta, K.4    Umemura, T.5    Takayanagi, R.6    Nawata, H.7
  • 71
    • 0016640079 scopus 로고
    • Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome
    • Lozzio C.B., Lozzio B.B. (1975) Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood;45:321–334.
    • (1975) Blood , vol.45 , pp. 321-334
    • Lozzio, C.B.1    Lozzio, B.B.2
  • 72
    • 0018395453 scopus 로고
    • Induction of erythroid differentiation in the human leukaemia cell line K562
    • Andersson L.C. (1979) Induction of erythroid differentiation in the human leukaemia cell line K562. Nature;278:364–365.
    • (1979) Nature , vol.278 , pp. 364-365
    • Andersson, L.C.1
  • 73
    • 0019975969 scopus 로고
    • Constitutive expression of platelet glycoproteins by the human leukemia cell line K562
    • Gewirtz A.M., Burger D., Rado T.A., Benz E.J., Hoffman R. (1982) Constitutive expression of platelet glycoproteins by the human leukemia cell line K562. Blood;60:785–789.
    • (1982) Blood , vol.60 , pp. 785-789
    • Gewirtz, A.M.1    Burger, D.2    Rado, T.A.3    Benz, E.J.4    Hoffman, R.5
  • 74
    • 34548820698 scopus 로고    scopus 로고
    • A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Δ12, 14 prostaglandin J2 production
    • Hasegawa H., Yamada Y., Komiyama K., Hayashi M., Ishibashi M., Sunazuka T., Izuhara T. (2007) A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Δ12, 14 prostaglandin J2 production. Blood;110:1664–1674.
    • (2007) Blood , vol.110 , pp. 1664-1674
    • Hasegawa, H.1    Yamada, Y.2    Komiyama, K.3    Hayashi, M.4    Ishibashi, M.5    Sunazuka, T.6    Izuhara, T.7
  • 75
    • 33749634311 scopus 로고    scopus 로고
    • Report dual PPARα/γLigand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines
    • Zang C., Liu H., Waechter M., Eucker J., Bertz J., Possinger K., Koeffler H.P. (2006) Report dual PPARα/γLigand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines. Cell Cycle;5:2237–2243.
    • (2006) Cell Cycle , vol.5 , pp. 2237-2243
    • Zang, C.1    Liu, H.2    Waechter, M.3    Eucker, J.4    Bertz, J.5    Possinger, K.6    Koeffler, H.P.7
  • 76
    • 84962175456 scopus 로고    scopus 로고
    • Differential effects of peroxisome proliferator-activated receptor agonists on doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells
    • Yousefi B., Samadi N., Baradaran B., Rameshknia V., Shafiei-Irannejad V., Majidinia M., Targhaze N., Zarghami N. (2015) Differential effects of peroxisome proliferator-activated receptor agonists on doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Cell Mol Biol;61:118–122.
    • (2015) Cell Mol Biol , vol.61 , pp. 118-122
    • Yousefi, B.1    Samadi, N.2    Baradaran, B.3    Rameshknia, V.4    Shafiei-Irannejad, V.5    Majidinia, M.6    Targhaze, N.7    Zarghami, N.8
  • 77
    • 12644265334 scopus 로고    scopus 로고
    • Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
    • Tontonoz P., Singer S., Forman B.M., Sarraf P., Fletcher J.A., Fletcher C.D., Brun R.P. (1997) Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc Natl Acad Sci USA;94:237–241.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 237-241
    • Tontonoz, P.1    Singer, S.2    Forman, B.M.3    Sarraf, P.4    Fletcher, J.A.5    Fletcher, C.D.6    Brun, R.P.7
  • 78
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P., Nagy L., Alvarez J.G., Thomazy V.A., Evans R.M. (1998) PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell;93:241–252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 79
    • 0032696319 scopus 로고    scopus 로고
    • Thiazolidinedione induces apoptosis and monocytic differentiation in the promyelocytic leukemia cell line HL60
    • Hirase N., Yanase T., Mu Y.-M., Muta K., Umemura T., Takayanagi R., Nawata H. (1999) Thiazolidinedione induces apoptosis and monocytic differentiation in the promyelocytic leukemia cell line HL60. Oncology;57(Suppl. 2):17–26.
    • (1999) Oncology , vol.57 , pp. 17-26
    • Hirase, N.1    Yanase, T.2    Mu, Y.-M.3    Muta, K.4    Umemura, T.5    Takayanagi, R.6    Nawata, H.7
  • 80
    • 20144387787 scopus 로고    scopus 로고
    • Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro
    • Liu J.J., Huang R.W., Lin D.J., Peng J., Wu X.Y., Lin Q., Pan X.L. (2005) Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. Ann Oncol;16:455–459.
    • (2005) Ann Oncol , vol.16 , pp. 455-459
    • Liu, J.J.1    Huang, R.W.2    Lin, D.J.3    Peng, J.4    Wu, X.Y.5    Lin, Q.6    Pan, X.L.7
  • 81
    • 68649093475 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone–induced apoptosis in leukemia k562 cells and its mechanisms of action
    • Liu J.J., Hu T., Wu X.Y., Wang C.Z., Xu Y., Zhang Y., Xiao R.Z. (2009) Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone–induced apoptosis in leukemia k562 cells and its mechanisms of action. Int J Toxicol;28:123–131.
    • (2009) Int J Toxicol , vol.28 , pp. 123-131
    • Liu, J.J.1    Hu, T.2    Wu, X.Y.3    Wang, C.Z.4    Xu, Y.5    Zhang, Y.6    Xiao, R.Z.7
  • 82
    • 33751192473 scopus 로고    scopus 로고
    • Journal club what are caspases 3 and 7 doing upstream of the mitochondria?
    • Kuribayashi K., Mayes P.A., El-Deiry W.S. (2006) Journal club what are caspases 3 and 7 doing upstream of the mitochondria? Cancer Biol Ther;5:763–765.
    • (2006) Cancer Biol Ther , vol.5 , pp. 763-765
    • Kuribayashi, K.1    Mayes, P.A.2    El-Deiry, W.S.3
  • 85
    • 0030725774 scopus 로고    scopus 로고
    • Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (P210BCR-ABL activates p65 NF-kappaB)
    • Hamdane M., David-Cordonnier M.-H., D'Halluin J.C. (1997) Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (P210BCR-ABL activates p65 NF-kappaB). Oncogene;15:2267–2275.
    • (1997) Oncogene , vol.15 , pp. 2267-2275
    • Hamdane, M.1    David-Cordonnier, M.-H.2    D'Halluin, J.C.3
  • 86
    • 33646430295 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18
    • Liu H., Zang C., Fenner M.H., Liu D., Possinger K., Koeffler H.P., Elstner E. (2006) Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18. Blood;107:3683–3692.
    • (2006) Blood , vol.107 , pp. 3683-3692
    • Liu, H.1    Zang, C.2    Fenner, M.H.3    Liu, D.4    Possinger, K.5    Koeffler, H.P.6    Elstner, E.7
  • 87
    • 84905283334 scopus 로고    scopus 로고
    • Akt and p53R2, partners that dictate the progression and invasiveness of cancer
    • Yousefi B., Samadi N., Ahmadi Y. (2014) Akt and p53R2, partners that dictate the progression and invasiveness of cancer. DNA Repair;22:24–29.
    • (2014) DNA Repair , vol.22 , pp. 24-29
    • Yousefi, B.1    Samadi, N.2    Ahmadi, Y.3
  • 88
    • 84866319957 scopus 로고    scopus 로고
    • Peroxisome proliferator–activated receptor activation increases imatinib uptake and killing of chronic myeloid leukemia cells
    • Wang L., Giannoudis A., Austin G., Clark R.E. (2012) Peroxisome proliferator–activated receptor activation increases imatinib uptake and killing of chronic myeloid leukemia cells. Exp Hematol;40:811–819 e2.
    • (2012) Exp Hematol , vol.40 , pp. 811-819
    • Wang, L.1    Giannoudis, A.2    Austin, G.3    Clark, R.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.