Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Science Translational Medicine

Volumn 7, Issue 304, 2015, Pages

  Modhiran, Naphak ^a   Watterson, Daniel ^a   Muller, David A ^a   Panetta, Adele K ^a   Sester, David P ^a   Liu, Lidong ^a,b   Hume, David A ^a,c   Stacey, Katryn J ^a   Young, Paul R ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; PATTERN RECOGNITION RECEPTOR; POLYMYXIN B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; VIRUS PROTEIN;

ACYLATION; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; DENGUE; DENGUE VIRUS; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IL 1BETA GENE; IL 6 GENE; IMMUNE RESPONSE; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RHODOBACTER SPHAEROIDES; VIRUS REPLICATION; VIRUS TRANSMISSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL ADHESION; DISEASE MODEL; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PATHOLOGY;

ANIMALS; CELL ADHESION; CYTOKINES; DENGUE VIRUS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; IMMUNOMODULATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MICE; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84941247956     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaa3863     Document Type: Article

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