메뉴 건너뛰기




Volumn 15, Issue 8, 2016, Pages 857-868

Genetic variations underlying Alzheimer's disease: Evidence from genome-wide association studies and beyond

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

EID: 84973308454     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(16)00127-7     Document Type: Review
Times cited : (218)

References (108)
  • 2
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:263-269.
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3
  • 3
    • 84900988440 scopus 로고    scopus 로고
    • Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
    • Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol 2014, 13:614-629.
    • (2014) Lancet Neurol , vol.13 , pp. 614-629
    • Dubois, B.1    Feldman, H.H.2    Jacova, C.3
  • 4
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 6
    • 56349116391 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease: an update
    • Brouwers N, Sleegers K, Van Broeckhoven C Molecular genetics of Alzheimer's disease: an update. Ann Med 2008, 40:562-583.
    • (2008) Ann Med , vol.40 , pp. 562-583
    • Brouwers, N.1    Sleegers, K.2    Van Broeckhoven, C.3
  • 8
    • 84930456033 scopus 로고    scopus 로고
    • The patterns of inheritance in early-onset dementia: Alzheimer's disease and frontotemporal dementia
    • Jarmolowicz AI, Chen HY, Panegyres PK The patterns of inheritance in early-onset dementia: Alzheimer's disease and frontotemporal dementia. Am J Alzheimers Dis Other Demen 2014, 30:299-306.
    • (2014) Am J Alzheimers Dis Other Demen , vol.30 , pp. 299-306
    • Jarmolowicz, A.I.1    Chen, H.Y.2    Panegyres, P.K.3
  • 9
    • 84862995971 scopus 로고    scopus 로고
    • The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers
    • Wallon D, Rousseau S, Rovelet-Lecrux A, et al. The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers. J Alzheimers Dis 2012, 30:847-856.
    • (2012) J Alzheimers Dis , vol.30 , pp. 847-856
    • Wallon, D.1    Rousseau, S.2    Rovelet-Lecrux, A.3
  • 10
    • 0035187434 scopus 로고    scopus 로고
    • Genetic risk of Alzheimer's disease: advising relatives
    • Liddell MB, Lovestone S, Owen MJ Genetic risk of Alzheimer's disease: advising relatives. Br J Psychiatry 2001, 178:7-11.
    • (2001) Br J Psychiatry , vol.178 , pp. 7-11
    • Liddell, M.B.1    Lovestone, S.2    Owen, M.J.3
  • 11
    • 0025768826 scopus 로고
    • Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies
    • van Duijn CM, Clayton D, Chandra V, et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991, 20(suppl 2):S13-S20.
    • (1991) Int J Epidemiol , vol.20 , pp. S13-S20
    • van Duijn, C.M.1    Clayton, D.2    Chandra, V.3
  • 12
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    • Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009, 41:1088-1093.
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3
  • 13
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    • Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011, 43:429-435.
    • (2011) Nat Genet , vol.43 , pp. 429-435
    • Hollingworth, P.1    Harold, D.2    Sims, R.3
  • 14
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    • Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009, 41:1094-1099.
    • (2009) Nat Genet , vol.41 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3
  • 15
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011, 43:436-441.
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3
  • 16
    • 77952307991 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic loci associated with Alzheimer disease
    • Seshadri S, Fitzpatrick AL, Ikram MA, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010, 303:1832-1840.
    • (2010) JAMA , vol.303 , pp. 1832-1840
    • Seshadri, S.1    Fitzpatrick, A.L.2    Ikram, M.A.3
  • 17
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013, 45:1452-1458.
    • (2013) Nat Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3
  • 18
    • 55049142500 scopus 로고    scopus 로고
    • Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
    • Bertram L, Lange C, Mullin K, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet 2008, 83:623-632.
    • (2008) Am J Hum Genet , vol.83 , pp. 623-632
    • Bertram, L.1    Lange, C.2    Mullin, K.3
  • 20
    • 84920703987 scopus 로고    scopus 로고
    • Alzheimer's disease risk genes and mechanisms of disease pathogenesis
    • Karch CM, Goate AM Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry 2015, 77:43-51.
    • (2015) Biol Psychiatry , vol.77 , pp. 43-51
    • Karch, C.M.1    Goate, A.M.2
  • 21
    • 79959396151 scopus 로고    scopus 로고
    • The three new pathways leading to Alzheimer's disease
    • Morgan K The three new pathways leading to Alzheimer's disease. Neuropathol Appl Neurobiol 2011, 37:353-357.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 353-357
    • Morgan, K.1
  • 22
    • 84937580795 scopus 로고    scopus 로고
    • Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities and plans
    • Saykin JS, Shen L, Yao X, et al. Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities and plans. Alzheimers Dement 2015, 11:792-814.
    • (2015) Alzheimers Dement , vol.11 , pp. 792-814
    • Saykin, J.S.1    Shen, L.2    Yao, X.3
  • 24
    • 84892971323 scopus 로고    scopus 로고
    • Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
    • Shulman JM, Imboywa S, Giagtzoglou N, et al. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet 2014, 23:870-877.
    • (2014) Hum Mol Genet , vol.23 , pp. 870-877
    • Shulman, J.M.1    Imboywa, S.2    Giagtzoglou, N.3
  • 25
    • 84890231680 scopus 로고    scopus 로고
    • Beyond GWASs: illuminating the dark road from association to function
    • Edwards SL, Beesley J, French JD, Dunning AM Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet 2013, 93:779-797.
    • (2013) Am J Hum Genet , vol.93 , pp. 779-797
    • Edwards, S.L.1    Beesley, J.2    French, J.D.3    Dunning, A.M.4
  • 26
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system
    • Bell RD, Sagare AP, Friedman AE, et al. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab 2007, 27:909-918.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 909-918
    • Bell, R.D.1    Sagare, A.P.2    Friedman, A.E.3
  • 27
    • 84855821393 scopus 로고    scopus 로고
    • Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    • Bettens K, Brouwers N, Engelborghs S, et al. Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk. Mol Neurodegener 2012, 7:3.
    • (2012) Mol Neurodegener , vol.7 , pp. 3
    • Bettens, K.1    Brouwers, N.2    Engelborghs, S.3
  • 28
    • 84899674587 scopus 로고    scopus 로고
    • Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings
    • Rosenthal SL, Barmada MM, Wang X, Demirci FY, Kamboh MI Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings. PLoS One 2014, 9:e95152.
    • (2014) PLoS One , vol.9
    • Rosenthal, S.L.1    Barmada, M.M.2    Wang, X.3    Demirci, F.Y.4    Kamboh, M.I.5
  • 29
    • 79960363619 scopus 로고    scopus 로고
    • Alzheimer's risk variants in the Clusterin gene are associated with alternative splicing
    • Szymanski M, Wang R, Bassett SS, Avramopoulos D Alzheimer's risk variants in the Clusterin gene are associated with alternative splicing. Transl Psychiatry 2011, 1:e18.
    • (2011) Transl Psychiatry , vol.1
    • Szymanski, M.1    Wang, R.2    Bassett, S.S.3    Avramopoulos, D.4
  • 30
    • 33646492644 scopus 로고    scopus 로고
    • Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms
    • Nilselid AM, Davidsson P, Nagga K, Andreasen N, Fredman P, Blennow K Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Neurochem Int 2006, 48:718-728.
    • (2006) Neurochem Int , vol.48 , pp. 718-728
    • Nilselid, A.M.1    Davidsson, P.2    Nagga, K.3    Andreasen, N.4    Fredman, P.5    Blennow, K.6
  • 31
    • 79960826290 scopus 로고    scopus 로고
    • Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
    • Schurmann B, Wiese B, Bickel H, et al. Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. J Alzheimers Dis 2011, 25:421-424.
    • (2011) J Alzheimers Dis , vol.25 , pp. 421-424
    • Schurmann, B.1    Wiese, B.2    Bickel, H.3
  • 32
    • 77954510398 scopus 로고    scopus 로고
    • Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
    • Thambisetty M, Simmons A, Velayudhan L, et al. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 2010, 67:739-748.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 739-748
    • Thambisetty, M.1    Simmons, A.2    Velayudhan, L.3
  • 33
    • 84884812572 scopus 로고    scopus 로고
    • Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease
    • Tan MS, Yu JT, Tan L Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease. Trends Mol Med 2013, 19:594-603.
    • (2013) Trends Mol Med , vol.19 , pp. 594-603
    • Tan, M.S.1    Yu, J.T.2    Tan, L.3
  • 34
    • 84888306100 scopus 로고    scopus 로고
    • Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
    • Chapuis J, Hansmannel F, Gistelinck M, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 2013, 18:1225-1234.
    • (2013) Mol Psychiatry , vol.18 , pp. 1225-1234
    • Chapuis, J.1    Hansmannel, F.2    Gistelinck, M.3
  • 36
    • 84881503738 scopus 로고    scopus 로고
    • CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing
    • Malik M, Simpson JF, Parikh I, et al. CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci 2013, 33:13320-13325.
    • (2013) J Neurosci , vol.33 , pp. 13320-13325
    • Malik, M.1    Simpson, J.F.2    Parikh, I.3
  • 37
    • 84898770218 scopus 로고    scopus 로고
    • CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
    • Raj T, Ryan KJ, Replogle JM, et al. CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility. Hum Mol Genet 2014, 23:2729-2736.
    • (2014) Hum Mol Genet , vol.23 , pp. 2729-2736
    • Raj, T.1    Ryan, K.J.2    Replogle, J.M.3
  • 38
    • 84878433339 scopus 로고    scopus 로고
    • Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
    • Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013, 78:631-643.
    • (2013) Neuron , vol.78 , pp. 631-643
    • Griciuc, A.1    Serrano-Pozo, A.2    Parrado, A.R.3
  • 39
    • 84856228504 scopus 로고    scopus 로고
    • Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites
    • Brouwers N, Van Cauwenberghe C, Engelborghs S, et al. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Mol Psychiatry 2011, 17:223-233.
    • (2011) Mol Psychiatry , vol.17 , pp. 223-233
    • Brouwers, N.1    Van Cauwenberghe, C.2    Engelborghs, S.3
  • 40
    • 84872462981 scopus 로고    scopus 로고
    • Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease
    • Szigeti K, Lal D, Li Y, et al. Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease. J Alzheimers Dis 2013, 33:517-523.
    • (2013) J Alzheimers Dis , vol.33 , pp. 517-523
    • Szigeti, K.1    Lal, D.2    Li, Y.3
  • 41
    • 84860488892 scopus 로고    scopus 로고
    • A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline
    • Keenan BT, Shulman JM, Chibnik LB, et al. A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet 2012, 21:2377-2388.
    • (2012) Hum Mol Genet , vol.21 , pp. 2377-2388
    • Keenan, B.T.1    Shulman, J.M.2    Chibnik, L.B.3
  • 42
    • 84878933308 scopus 로고    scopus 로고
    • CR1 coding variant p.Ser1610Thr in Alzheimer disease and related endophenotypes
    • Van Cauwenberghe C, Bettens K, Engelborghs S, et al. CR1 coding variant p.Ser1610Thr in Alzheimer disease and related endophenotypes. Neurobiol Aging 2013, 34:2235.e1-2235.e6.
    • (2013) Neurobiol Aging , vol.34 , pp. 2235.e1-2235.e6
    • Van Cauwenberghe, C.1    Bettens, K.2    Engelborghs, S.3
  • 43
    • 33846613222 scopus 로고    scopus 로고
    • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    • Rogaeva E, Meng Y, Lee JH, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007, 39:168-177.
    • (2007) Nat Genet , vol.39 , pp. 168-177
    • Rogaeva, E.1    Meng, Y.2    Lee, J.H.3
  • 44
    • 84875661996 scopus 로고    scopus 로고
    • SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
    • Miyashita A, Koike A, Jun G, et al. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One 2013, 8:e58618.
    • (2013) PLoS One , vol.8
    • Miyashita, A.1    Koike, A.2    Jun, G.3
  • 46
    • 0036869032 scopus 로고    scopus 로고
    • Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA
    • Lintzel J, Franke I, Riedel IB, Schaller HC, Hampe W Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA. Biol Chem 2002, 383:1727-1733.
    • (2002) Biol Chem , vol.383 , pp. 1727-1733
    • Lintzel, J.1    Franke, I.2    Riedel, I.B.3    Schaller, H.C.4    Hampe, W.5
  • 47
    • 84922718986 scopus 로고    scopus 로고
    • Coding mutations in SORL1 and Alzheimer disease
    • Vardarajan BN, Zhang Y, Lee JH, et al. Coding mutations in SORL1 and Alzheimer disease. Ann Neurol 2015, 77:215-227.
    • (2015) Ann Neurol , vol.77 , pp. 215-227
    • Vardarajan, B.N.1    Zhang, Y.2    Lee, J.H.3
  • 48
    • 84875922261 scopus 로고    scopus 로고
    • Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ε4, and the risk of late-onset Alzheimer disease in African Americans
    • Reitz C, Jun G, Naj A, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ε4, and the risk of late-onset Alzheimer disease in African Americans. JAMA 2013, 309:1483-1492.
    • (2013) JAMA , vol.309 , pp. 1483-1492
    • Reitz, C.1    Jun, G.2    Naj, A.3
  • 49
    • 85020160519 scopus 로고    scopus 로고
    • ABCA7 deletion associated with Alzheimer's disease in African Americans
    • for the Alzheimer Disease Genetics Consortium
    • Cukier HN, Kunkle BW, Rolati S, et al. ABCA7 deletion associated with Alzheimer's disease in African Americans. Alzheimers Dement 2015, 11(suppl):P485-P486. for the Alzheimer Disease Genetics Consortium.
    • (2015) Alzheimers Dement , vol.11 , pp. P485-P486
    • Cukier, H.N.1    Kunkle, B.W.2    Rolati, S.3
  • 50
    • 84937526438 scopus 로고    scopus 로고
    • Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study
    • Cuyvers E, De Roeck A, Van den Bossche T, et al. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study. Lancet Neurol 2015, 14:814-822.
    • (2015) Lancet Neurol , vol.14 , pp. 814-822
    • Cuyvers, E.1    De Roeck, A.2    Van den Bossche, T.3
  • 51
    • 84929432198 scopus 로고    scopus 로고
    • Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
    • Steinberg S, Stefansson H, Jonsson T, et al. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. Nat Genet 2015, 47:445-447.
    • (2015) Nat Genet , vol.47 , pp. 445-447
    • Steinberg, S.1    Stefansson, H.2    Jonsson, T.3
  • 52
    • 84939654955 scopus 로고    scopus 로고
    • Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci
    • Vardarajan BN, Ghani M, Kahn A, et al. Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci. Ann Neurol 2015, 78:487-498.
    • (2015) Ann Neurol , vol.78 , pp. 487-498
    • Vardarajan, B.N.1    Ghani, M.2    Kahn, A.3
  • 53
    • 84908207773 scopus 로고    scopus 로고
    • The contribution of genetic variants to disease depends on the ruler
    • Witte JS, Visscher PM, Wray NR The contribution of genetic variants to disease depends on the ruler. Nat Rev Genet 2014, 15:765-776.
    • (2014) Nat Rev Genet , vol.15 , pp. 765-776
    • Witte, J.S.1    Visscher, P.M.2    Wray, N.R.3
  • 55
    • 84873031286 scopus 로고    scopus 로고
    • Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
    • Lee SH, Harold D, Nyholt DR, et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet 2013, 22:832-841.
    • (2013) Hum Mol Genet , vol.22 , pp. 832-841
    • Lee, S.H.1    Harold, D.2    Nyholt, D.R.3
  • 56
    • 32244435907 scopus 로고    scopus 로고
    • Role of genes and environments for explaining Alzheimer disease
    • Gatz M, Reynolds CA, Fratiglioni L, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 2006, 63:168-174.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 168-174
    • Gatz, M.1    Reynolds, C.A.2    Fratiglioni, L.3
  • 57
    • 79952489475 scopus 로고    scopus 로고
    • Estimating missing heritability for disease from genome-wide association studies
    • Lee SH, Wray NR, Goddard ME, Visscher PM Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011, 88:294-305.
    • (2011) Am J Hum Genet , vol.88 , pp. 294-305
    • Lee, S.H.1    Wray, N.R.2    Goddard, M.E.3    Visscher, P.M.4
  • 58
    • 36249023276 scopus 로고    scopus 로고
    • Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
    • Seshadri S, Wolf PA Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study. Lancet Neurol 2007, 6:1106-1114.
    • (2007) Lancet Neurol , vol.6 , pp. 1106-1114
    • Seshadri, S.1    Wolf, P.A.2
  • 59
    • 80052070571 scopus 로고    scopus 로고
    • APOE and Alzheimer disease: a major gene with semi-dominant inheritance
    • Genin E, Hannequin D, Wallon D, et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 2011, 16:903-907.
    • (2011) Mol Psychiatry , vol.16 , pp. 903-907
    • Genin, E.1    Hannequin, D.2    Wallon, D.3
  • 60
    • 84889590173 scopus 로고    scopus 로고
    • Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia
    • Cuyvers E, Bettens K, Philtjens S, et al. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia. Neurobiol Aging 2014, 35:726-729.
    • (2014) Neurobiol Aging , vol.35 , pp. 726-729
    • Cuyvers, E.1    Bettens, K.2    Philtjens, S.3
  • 62
    • 85020144222 scopus 로고    scopus 로고
    • Low-frequency variant imputation identifies rare variant candidate loci in a GWAS of late-onset Alzheimer disease in the IGAP Consortium
    • for The International Genomics of Alzheimer's Project (IGAP)
    • Kunkle B, Grenier-Boley B, Vronskaya M, et al. Low-frequency variant imputation identifies rare variant candidate loci in a GWAS of late-onset Alzheimer disease in the IGAP Consortium. Alzheimers Dement 2015, 11(suppl):P333-P334. for The International Genomics of Alzheimer's Project (IGAP).
    • (2015) Alzheimers Dement , vol.11 , pp. P333-P334
    • Kunkle, B.1    Grenier-Boley, B.2    Vronskaya, M.3
  • 63
    • 84873726158 scopus 로고    scopus 로고
    • Alzheimer's disease genes and cognition in the nondemented general population
    • Verhaaren BF, Vernooij MW, Koudstaal PJ, et al. Alzheimer's disease genes and cognition in the nondemented general population. Biol Psychiatry 2013, 73:429-434.
    • (2013) Biol Psychiatry , vol.73 , pp. 429-434
    • Verhaaren, B.F.1    Vernooij, M.W.2    Koudstaal, P.J.3
  • 64
    • 84898858439 scopus 로고    scopus 로고
    • Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions
    • Ebbert MT, Ridge PG, Wilson AR, et al. Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions. Biol Psychiatry 2014, 75:732-737.
    • (2014) Biol Psychiatry , vol.75 , pp. 732-737
    • Ebbert, M.T.1    Ridge, P.G.2    Wilson, A.R.3
  • 65
    • 77958102016 scopus 로고    scopus 로고
    • Statistical analysis strategies for association studies involving rare variants
    • Bansal V, Libiger O, Torkamani A, Schork NJ Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet 2010, 11:773-783.
    • (2010) Nat Rev Genet , vol.11 , pp. 773-783
    • Bansal, V.1    Libiger, O.2    Torkamani, A.3    Schork, N.J.4
  • 66
    • 84872057940 scopus 로고    scopus 로고
    • TREM2 variants in Alzheimer's disease
    • Guerreiro R, Wojtas A, Bras J, et al. TREM2 variants in Alzheimer's disease. N Engl J Med 2013, 368:117-127.
    • (2013) N Engl J Med , vol.368 , pp. 117-127
    • Guerreiro, R.1    Wojtas, A.2    Bras, J.3
  • 67
    • 84872088087 scopus 로고    scopus 로고
    • Variant of TREM2 associated with the risk of Alzheimer's disease
    • Jonsson T, Stefansson H, Steinberg S, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 2013, 368:107-116.
    • (2013) N Engl J Med , vol.368 , pp. 107-116
    • Jonsson, T.1    Stefansson, H.2    Steinberg, S.3
  • 68
    • 84938418325 scopus 로고    scopus 로고
    • What happens to microglial TREM2 in Alzheimer's disease: immunoregulatory turned into immunopathogenic?
    • Lue LF, Schmitz C, Walker DG What happens to microglial TREM2 in Alzheimer's disease: immunoregulatory turned into immunopathogenic?. Neuroscience 2015, 302:138-150.
    • (2015) Neuroscience , vol.302 , pp. 138-150
    • Lue, L.F.1    Schmitz, C.2    Walker, D.G.3
  • 69
    • 84904479732 scopus 로고    scopus 로고
    • TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
    • 243ra86
    • Kleinberger G, Yamanishi Y, Suarez-Calvet M, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med 2014, 6:243ra86.
    • (2014) Sci Transl Med , vol.6
    • Kleinberger, G.1    Yamanishi, Y.2    Suarez-Calvet, M.3
  • 70
    • 84902243410 scopus 로고    scopus 로고
    • Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2
    • Ulrich JD, Finn MB, Wang Y, et al. Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2. Mol Neurodegener 2014, 9:20.
    • (2014) Mol Neurodegener , vol.9 , pp. 20
    • Ulrich, J.D.1    Finn, M.B.2    Wang, Y.3
  • 71
    • 84866368227 scopus 로고    scopus 로고
    • High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease
    • Pottier C, Hannequin D, Coutant S, et al. High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease. Mol Psychiatry 2012, 17:875-879.
    • (2012) Mol Psychiatry , vol.17 , pp. 875-879
    • Pottier, C.1    Hannequin, D.2    Coutant, S.3
  • 72
    • 84940054847 scopus 로고    scopus 로고
    • SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease
    • Nicolas G, Charbonnier C, Wallon D, et al. SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease. Mol Psychiatry 2016, 21:831-836.
    • (2016) Mol Psychiatry , vol.21 , pp. 831-836
    • Nicolas, G.1    Charbonnier, C.2    Wallon, D.3
  • 73
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012, 488:96-99.
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3
  • 74
    • 84877618309 scopus 로고    scopus 로고
    • Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
    • Giraldo M, Lopera F, Siniard AL, et al. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiol Aging 2013, 34:2077.e11-2077.e18.
    • (2013) Neurobiol Aging , vol.34 , pp. 2077.e11-2077.e18
    • Giraldo, M.1    Lopera, F.2    Siniard, A.L.3
  • 75
    • 84875261136 scopus 로고    scopus 로고
    • TREM2 is associated with the risk of Alzheimer's disease in Spanish population
    • Benitez BA, Cooper B, Pastor P, et al. TREM2 is associated with the risk of Alzheimer's disease in Spanish population. Neurobiol Aging 2013, 34:1711.e15-1711.e17.
    • (2013) Neurobiol Aging , vol.34 , pp. 1711.e15-1711.e17
    • Benitez, B.A.1    Cooper, B.2    Pastor, P.3
  • 76
    • 84876398977 scopus 로고    scopus 로고
    • TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease
    • Pottier C, Wallon D, Rousseau S, et al. TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. J Alzheimers Dis 2013, 35:45-49.
    • (2013) J Alzheimers Dis , vol.35 , pp. 45-49
    • Pottier, C.1    Wallon, D.2    Rousseau, S.3
  • 77
    • 84892819277 scopus 로고    scopus 로고
    • Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
    • Cruchaga C, Karch CM, Jin SC, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 2014, 505:550-554.
    • (2014) Nature , vol.505 , pp. 550-554
    • Cruchaga, C.1    Karch, C.M.2    Jin, S.C.3
  • 79
    • 84926339944 scopus 로고    scopus 로고
    • PLD3 in non-familial Alzheimer's disease
    • Heilmann S, Drichel D, Clarimon J, et al. PLD3 in non-familial Alzheimer's disease. Nature 2015, 520:E3-E5.
    • (2015) Nature , vol.520 , pp. E3-E5
    • Heilmann, S.1    Drichel, D.2    Clarimon, J.3
  • 80
    • 84926293839 scopus 로고    scopus 로고
    • PLD3 gene variants and Alzheimer's disease
    • Hooli BV, Lill CM, Mullin K, et al. PLD3 gene variants and Alzheimer's disease. Nature 2015, 520:E7-E8.
    • (2015) Nature , vol.520 , pp. E7-E8
    • Hooli, B.V.1    Lill, C.M.2    Mullin, K.3
  • 81
    • 84926335825 scopus 로고    scopus 로고
    • PLD3 variants in population studies
    • van der Lee SJ, Holstege H, Wong TH, et al. PLD3 variants in population studies. Nature 2015, 520:E2-E3.
    • (2015) Nature , vol.520 , pp. E2-E3
    • van der Lee, S.J.1    Holstege, H.2    Wong, T.H.3
  • 82
    • 84923041272 scopus 로고    scopus 로고
    • Rarity of the Alzheimer disease-protective APP A673T variant in the United States
    • Wang LS, Naj AC, Graham RR, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 2015, 72:209-216.
    • (2015) JAMA Neurol , vol.72 , pp. 209-216
    • Wang, L.S.1    Naj, A.C.2    Graham, R.R.3
  • 83
    • 85058205674 scopus 로고    scopus 로고
    • Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease
    • Bamne MN, Demirci FY, Berman S, et al. Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease. Neurobiol Aging 2014, 35:1779.e15-1779.e16.
    • (2014) Neurobiol Aging , vol.35 , pp. 1779.e15-1779.e16
    • Bamne, M.N.1    Demirci, F.Y.2    Berman, S.3
  • 84
    • 85058205844 scopus 로고    scopus 로고
    • Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals
    • Liu YW, He YH, Zhang YX, et al. Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals. Neurobiol Aging 2014, 35:935.e11-935.e12.
    • (2014) Neurobiol Aging , vol.35 , pp. 935.e11-935.e12
    • Liu, Y.W.1    He, Y.H.2    Zhang, Y.X.3
  • 85
    • 84873454554 scopus 로고    scopus 로고
    • Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population
    • Kero M, Paetau A, Polvikoski T, et al. Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population. Neurobiol Aging 2013, 34:1518.e1-1518.e3.
    • (2013) Neurobiol Aging , vol.34 , pp. 1518.e1-1518.e3
    • Kero, M.1    Paetau, A.2    Polvikoski, T.3
  • 87
    • 84988662285 scopus 로고    scopus 로고
    • Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
    • Bettens K, Vermeulen S, Van Cauwenberghe C, et al. Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations. Mol Neurodegener 2015, 10:30.
    • (2015) Mol Neurodegener , vol.10 , pp. 30
    • Bettens, K.1    Vermeulen, S.2    Van Cauwenberghe, C.3
  • 88
    • 84896360551 scopus 로고    scopus 로고
    • Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation
    • 223ra20
    • Caglayan S, Takagi-Niidome S, Liao F, et al. Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med 2014, 6:223ra20.
    • (2014) Sci Transl Med , vol.6
    • Caglayan, S.1    Takagi-Niidome, S.2    Liao, F.3
  • 89
    • 84943279590 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing
    • Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem 2015, 290:24152-24165.
    • (2015) J Biol Chem , vol.290 , pp. 24152-24165
    • Satoh, K.1    Abe-Dohmae, S.2    Yokoyama, S.3    St George-Hyslop, P.4    Fraser, P.E.5
  • 90
    • 84938912653 scopus 로고    scopus 로고
    • R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: clinical, genetic, and neuropathological study
    • Korvatska O, Leverenz JB, Jayadev S, et al. R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: clinical, genetic, and neuropathological study. JAMA Neurol 2015, 72:920-927.
    • (2015) JAMA Neurol , vol.72 , pp. 920-927
    • Korvatska, O.1    Leverenz, J.B.2    Jayadev, S.3
  • 91
    • 84884592445 scopus 로고    scopus 로고
    • Genic intolerance to functional variation and the interpretation of personal genomes
    • Petrovski S, Wang Q, Heinzen EL, Allen AS, Goldstein DB Genic intolerance to functional variation and the interpretation of personal genomes. PLoS Genet 2013, 9:e1003709.
    • (2013) PLoS Genet , vol.9
    • Petrovski, S.1    Wang, Q.2    Heinzen, E.L.3    Allen, A.S.4    Goldstein, D.B.5
  • 93
    • 84926191670 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
    • for the ODYSSEY LONG TERM Investigators
    • Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015, 372:1489-1499. for the ODYSSEY LONG TERM Investigators.
    • (2015) N Engl J Med , vol.372 , pp. 1489-1499
    • Robinson, J.G.1    Farnier, M.2    Krempf, M.3
  • 94
    • 84926206074 scopus 로고    scopus 로고
    • Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • for the Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators
    • Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015, 372:1500-1509. for the Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators.
    • (2015) N Engl J Med , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1    Giugliano, R.P.2    Wiviott, S.D.3
  • 95
    • 84930442437 scopus 로고    scopus 로고
    • Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia
    • Malik M, Chiles J, Xi HS, et al. Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia. Hum Mol Genet 2015, 24:3557-3570.
    • (2015) Hum Mol Genet , vol.24 , pp. 3557-3570
    • Malik, M.1    Chiles, J.2    Xi, H.S.3
  • 96
    • 84930332837 scopus 로고    scopus 로고
    • Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics
    • American College of Medical Genetics and Genomics Board of Directors
    • Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics. Genet Med 2015, 17:505-507. American College of Medical Genetics and Genomics Board of Directors.
    • (2015) Genet Med , vol.17 , pp. 505-507
  • 97
    • 84884979769 scopus 로고    scopus 로고
    • Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial
    • Mills SM, Mallmann J, Santacruz AM, et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris) 2013, 169:737-743.
    • (2013) Rev Neurol (Paris) , vol.169 , pp. 737-743
    • Mills, S.M.1    Mallmann, J.2    Santacruz, A.M.3
  • 98
    • 80055034288 scopus 로고    scopus 로고
    • Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments
    • Reiman EM, Langbaum JB, Fleisher AS, et al. Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J Alzheimers Dis 2011, 26(suppl 3):321-329.
    • (2011) J Alzheimers Dis , vol.26 , pp. 321-329
    • Reiman, E.M.1    Langbaum, J.B.2    Fleisher, A.S.3
  • 99
    • 79959193198 scopus 로고    scopus 로고
    • Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors
    • Goldman JS, Hahn SE, Catania JW, et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med 2011, 13:597-605.
    • (2011) Genet Med , vol.13 , pp. 597-605
    • Goldman, J.S.1    Hahn, S.E.2    Catania, J.W.3
  • 100
    • 84878012313 scopus 로고    scopus 로고
    • Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease
    • Rodriguez-Rodriguez E, Sanchez-Juan P, Vazquez-Higuera JL, et al. Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease. J Neural Transm 2013, 120:807-812.
    • (2013) J Neural Transm , vol.120 , pp. 807-812
    • Rodriguez-Rodriguez, E.1    Sanchez-Juan, P.2    Vazquez-Higuera, J.L.3
  • 101
    • 84911906938 scopus 로고    scopus 로고
    • Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach
    • Martiskainen H, Helisalmi S, Viswanathan J, et al. Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach. J Alzheimers Dis 2015, 43:565-573.
    • (2015) J Alzheimers Dis , vol.43 , pp. 565-573
    • Martiskainen, H.1    Helisalmi, S.2    Viswanathan, J.3
  • 102
    • 84952630745 scopus 로고    scopus 로고
    • A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Abeta
    • Sleegers K, Bettens K, De Roeck A, et al. A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Abeta. Alzheimers Dement 2015, 11:1452-1460.
    • (2015) Alzheimers Dement , vol.11 , pp. 1452-1460
    • Sleegers, K.1    Bettens, K.2    De Roeck, A.3
  • 103
    • 84925295495 scopus 로고    scopus 로고
    • Association of Alzheimer's disease GWAS loci with MRI markers of brain aging
    • Chauhan G, Adams HH, Bis JC, et al. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiol Aging 2015, 36:1765.e7-1765.e16.
    • (2015) Neurobiol Aging , vol.36 , pp. 1765.e7-1765.e16
    • Chauhan, G.1    Adams, H.H.2    Bis, J.C.3
  • 104
    • 84934271687 scopus 로고    scopus 로고
    • Predicting Alzheimer's disease using combined imaging-whole genome SNP data
    • Kong D, Giovanello KS, Wang Y, et al. Predicting Alzheimer's disease using combined imaging-whole genome SNP data. J Alzheimers Dis 2015, 46:695-702.
    • (2015) J Alzheimers Dis , vol.46 , pp. 695-702
    • Kong, D.1    Giovanello, K.S.2    Wang, Y.3
  • 105
    • 84884508338 scopus 로고    scopus 로고
    • Incremental value of rare genetic variants for the prediction of multifactorial diseases
    • Mihaescu R, Pencina MJ, Alonso A, et al. Incremental value of rare genetic variants for the prediction of multifactorial diseases. Genome Med 2013, 5:76.
    • (2013) Genome Med , vol.5 , pp. 76
    • Mihaescu, R.1    Pencina, M.J.2    Alonso, A.3
  • 106
    • 84938510452 scopus 로고    scopus 로고
    • Personalized medicine for effective Alzheimer disease treatment
    • Kosik KS Personalized medicine for effective Alzheimer disease treatment. JAMA Neurol 2015, 72:497-498.
    • (2015) JAMA Neurol , vol.72 , pp. 497-498
    • Kosik, K.S.1
  • 107
    • 84946398793 scopus 로고    scopus 로고
    • Precision medicine: clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases
    • Montine TJ, Montine KS Precision medicine: clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases. J Exp Med 2015, 212:601-605.
    • (2015) J Exp Med , vol.212 , pp. 601-605
    • Montine, T.J.1    Montine, K.S.2
  • 108
    • 84896829795 scopus 로고    scopus 로고
    • A genotype-first approach to defining the subtypes of a complex disease
    • Stessman HA, Bernier R, Eichler EE A genotype-first approach to defining the subtypes of a complex disease. Cell 2014, 156:872-877.
    • (2014) Cell , vol.156 , pp. 872-877
    • Stessman, H.A.1    Bernier, R.2    Eichler, E.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.