-
1
-
-
84941331228
-
-
Alzheimer's Disease International, Alzheimer's Disease International, London
-
World Alzheimer report 2015: the global impact of dementia, an analysis of prevalence, incidence, costs and trends 2015, Alzheimer's Disease International, Alzheimer's Disease International, London.
-
(2015)
World Alzheimer report 2015: the global impact of dementia, an analysis of prevalence, incidence, costs and trends
-
-
-
2
-
-
79956142378
-
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:263-269.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 263-269
-
-
McKhann, G.M.1
Knopman, D.S.2
Chertkow, H.3
-
3
-
-
84900988440
-
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
-
Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol 2014, 13:614-629.
-
(2014)
Lancet Neurol
, vol.13
, pp. 614-629
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
-
4
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H, Braak E Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
6
-
-
56349116391
-
Molecular genetics of Alzheimer's disease: an update
-
Brouwers N, Sleegers K, Van Broeckhoven C Molecular genetics of Alzheimer's disease: an update. Ann Med 2008, 40:562-583.
-
(2008)
Ann Med
, vol.40
, pp. 562-583
-
-
Brouwers, N.1
Sleegers, K.2
Van Broeckhoven, C.3
-
7
-
-
33846913643
-
Early-onset Alzheimer's disease is associated with greater pathologic burden
-
Marshall GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL Early-onset Alzheimer's disease is associated with greater pathologic burden. J Geriatr Psychiatry Neurol 2007, 20:29-33.
-
(2007)
J Geriatr Psychiatry Neurol
, vol.20
, pp. 29-33
-
-
Marshall, G.A.1
Fairbanks, L.A.2
Tekin, S.3
Vinters, H.V.4
Cummings, J.L.5
-
8
-
-
84930456033
-
The patterns of inheritance in early-onset dementia: Alzheimer's disease and frontotemporal dementia
-
Jarmolowicz AI, Chen HY, Panegyres PK The patterns of inheritance in early-onset dementia: Alzheimer's disease and frontotemporal dementia. Am J Alzheimers Dis Other Demen 2014, 30:299-306.
-
(2014)
Am J Alzheimers Dis Other Demen
, vol.30
, pp. 299-306
-
-
Jarmolowicz, A.I.1
Chen, H.Y.2
Panegyres, P.K.3
-
9
-
-
84862995971
-
The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers
-
Wallon D, Rousseau S, Rovelet-Lecrux A, et al. The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers. J Alzheimers Dis 2012, 30:847-856.
-
(2012)
J Alzheimers Dis
, vol.30
, pp. 847-856
-
-
Wallon, D.1
Rousseau, S.2
Rovelet-Lecrux, A.3
-
10
-
-
0035187434
-
Genetic risk of Alzheimer's disease: advising relatives
-
Liddell MB, Lovestone S, Owen MJ Genetic risk of Alzheimer's disease: advising relatives. Br J Psychiatry 2001, 178:7-11.
-
(2001)
Br J Psychiatry
, vol.178
, pp. 7-11
-
-
Liddell, M.B.1
Lovestone, S.2
Owen, M.J.3
-
11
-
-
0025768826
-
Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies
-
van Duijn CM, Clayton D, Chandra V, et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991, 20(suppl 2):S13-S20.
-
(1991)
Int J Epidemiol
, vol.20
, pp. S13-S20
-
-
van Duijn, C.M.1
Clayton, D.2
Chandra, V.3
-
12
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009, 41:1088-1093.
-
(2009)
Nat Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
-
13
-
-
79955484414
-
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011, 43:429-435.
-
(2011)
Nat Genet
, vol.43
, pp. 429-435
-
-
Hollingworth, P.1
Harold, D.2
Sims, R.3
-
14
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009, 41:1094-1099.
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
-
15
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
-
Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011, 43:436-441.
-
(2011)
Nat Genet
, vol.43
, pp. 436-441
-
-
Naj, A.C.1
Jun, G.2
Beecham, G.W.3
-
16
-
-
77952307991
-
Genome-wide analysis of genetic loci associated with Alzheimer disease
-
Seshadri S, Fitzpatrick AL, Ikram MA, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010, 303:1832-1840.
-
(2010)
JAMA
, vol.303
, pp. 1832-1840
-
-
Seshadri, S.1
Fitzpatrick, A.L.2
Ikram, M.A.3
-
17
-
-
84888317489
-
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
-
Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013, 45:1452-1458.
-
(2013)
Nat Genet
, vol.45
, pp. 1452-1458
-
-
Lambert, J.C.1
Ibrahim-Verbaas, C.A.2
Harold, D.3
-
18
-
-
55049142500
-
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
-
Bertram L, Lange C, Mullin K, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet 2008, 83:623-632.
-
(2008)
Am J Hum Genet
, vol.83
, pp. 623-632
-
-
Bertram, L.1
Lange, C.2
Mullin, K.3
-
20
-
-
84920703987
-
Alzheimer's disease risk genes and mechanisms of disease pathogenesis
-
Karch CM, Goate AM Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry 2015, 77:43-51.
-
(2015)
Biol Psychiatry
, vol.77
, pp. 43-51
-
-
Karch, C.M.1
Goate, A.M.2
-
21
-
-
79959396151
-
The three new pathways leading to Alzheimer's disease
-
Morgan K The three new pathways leading to Alzheimer's disease. Neuropathol Appl Neurobiol 2011, 37:353-357.
-
(2011)
Neuropathol Appl Neurobiol
, vol.37
, pp. 353-357
-
-
Morgan, K.1
-
22
-
-
84937580795
-
Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities and plans
-
Saykin JS, Shen L, Yao X, et al. Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities and plans. Alzheimers Dement 2015, 11:792-814.
-
(2015)
Alzheimers Dement
, vol.11
, pp. 792-814
-
-
Saykin, J.S.1
Shen, L.2
Yao, X.3
-
23
-
-
84936074140
-
Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci
-
Humphries C, Kohli MA, Whitehead P, Mash DC, Pericak-Vance MA, Gilbert J Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci. Mol Cell Neurosci 2015, 67:37-45.
-
(2015)
Mol Cell Neurosci
, vol.67
, pp. 37-45
-
-
Humphries, C.1
Kohli, M.A.2
Whitehead, P.3
Mash, D.C.4
Pericak-Vance, M.A.5
Gilbert, J.6
-
24
-
-
84892971323
-
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
-
Shulman JM, Imboywa S, Giagtzoglou N, et al. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet 2014, 23:870-877.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 870-877
-
-
Shulman, J.M.1
Imboywa, S.2
Giagtzoglou, N.3
-
25
-
-
84890231680
-
Beyond GWASs: illuminating the dark road from association to function
-
Edwards SL, Beesley J, French JD, Dunning AM Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet 2013, 93:779-797.
-
(2013)
Am J Hum Genet
, vol.93
, pp. 779-797
-
-
Edwards, S.L.1
Beesley, J.2
French, J.D.3
Dunning, A.M.4
-
26
-
-
34247506244
-
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system
-
Bell RD, Sagare AP, Friedman AE, et al. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab 2007, 27:909-918.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 909-918
-
-
Bell, R.D.1
Sagare, A.P.2
Friedman, A.E.3
-
27
-
-
84855821393
-
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
-
Bettens K, Brouwers N, Engelborghs S, et al. Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk. Mol Neurodegener 2012, 7:3.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 3
-
-
Bettens, K.1
Brouwers, N.2
Engelborghs, S.3
-
28
-
-
84899674587
-
Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings
-
Rosenthal SL, Barmada MM, Wang X, Demirci FY, Kamboh MI Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings. PLoS One 2014, 9:e95152.
-
(2014)
PLoS One
, vol.9
-
-
Rosenthal, S.L.1
Barmada, M.M.2
Wang, X.3
Demirci, F.Y.4
Kamboh, M.I.5
-
29
-
-
79960363619
-
Alzheimer's risk variants in the Clusterin gene are associated with alternative splicing
-
Szymanski M, Wang R, Bassett SS, Avramopoulos D Alzheimer's risk variants in the Clusterin gene are associated with alternative splicing. Transl Psychiatry 2011, 1:e18.
-
(2011)
Transl Psychiatry
, vol.1
-
-
Szymanski, M.1
Wang, R.2
Bassett, S.S.3
Avramopoulos, D.4
-
30
-
-
33646492644
-
Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms
-
Nilselid AM, Davidsson P, Nagga K, Andreasen N, Fredman P, Blennow K Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Neurochem Int 2006, 48:718-728.
-
(2006)
Neurochem Int
, vol.48
, pp. 718-728
-
-
Nilselid, A.M.1
Davidsson, P.2
Nagga, K.3
Andreasen, N.4
Fredman, P.5
Blennow, K.6
-
31
-
-
79960826290
-
Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
-
Schurmann B, Wiese B, Bickel H, et al. Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. J Alzheimers Dis 2011, 25:421-424.
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 421-424
-
-
Schurmann, B.1
Wiese, B.2
Bickel, H.3
-
32
-
-
77954510398
-
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
-
Thambisetty M, Simmons A, Velayudhan L, et al. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 2010, 67:739-748.
-
(2010)
Arch Gen Psychiatry
, vol.67
, pp. 739-748
-
-
Thambisetty, M.1
Simmons, A.2
Velayudhan, L.3
-
33
-
-
84884812572
-
Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease
-
Tan MS, Yu JT, Tan L Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease. Trends Mol Med 2013, 19:594-603.
-
(2013)
Trends Mol Med
, vol.19
, pp. 594-603
-
-
Tan, M.S.1
Yu, J.T.2
Tan, L.3
-
34
-
-
84888306100
-
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
-
Chapuis J, Hansmannel F, Gistelinck M, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 2013, 18:1225-1234.
-
(2013)
Mol Psychiatry
, vol.18
, pp. 1225-1234
-
-
Chapuis, J.1
Hansmannel, F.2
Gistelinck, M.3
-
35
-
-
0032699774
-
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor
-
Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol 1999, 29:3440-3449.
-
(1999)
Eur J Immunol
, vol.29
, pp. 3440-3449
-
-
Ulyanova, T.1
Blasioli, J.2
Woodford-Thomas, T.A.3
Thomas, M.L.4
-
36
-
-
84881503738
-
CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing
-
Malik M, Simpson JF, Parikh I, et al. CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci 2013, 33:13320-13325.
-
(2013)
J Neurosci
, vol.33
, pp. 13320-13325
-
-
Malik, M.1
Simpson, J.F.2
Parikh, I.3
-
37
-
-
84898770218
-
CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
-
Raj T, Ryan KJ, Replogle JM, et al. CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility. Hum Mol Genet 2014, 23:2729-2736.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 2729-2736
-
-
Raj, T.1
Ryan, K.J.2
Replogle, J.M.3
-
38
-
-
84878433339
-
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013, 78:631-643.
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
-
39
-
-
84856228504
-
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites
-
Brouwers N, Van Cauwenberghe C, Engelborghs S, et al. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Mol Psychiatry 2011, 17:223-233.
-
(2011)
Mol Psychiatry
, vol.17
, pp. 223-233
-
-
Brouwers, N.1
Van Cauwenberghe, C.2
Engelborghs, S.3
-
40
-
-
84872462981
-
Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease
-
Szigeti K, Lal D, Li Y, et al. Genome-wide scan for copy number variation association with age at onset of Alzheimer's disease. J Alzheimers Dis 2013, 33:517-523.
-
(2013)
J Alzheimers Dis
, vol.33
, pp. 517-523
-
-
Szigeti, K.1
Lal, D.2
Li, Y.3
-
41
-
-
84860488892
-
A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline
-
Keenan BT, Shulman JM, Chibnik LB, et al. A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet 2012, 21:2377-2388.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 2377-2388
-
-
Keenan, B.T.1
Shulman, J.M.2
Chibnik, L.B.3
-
42
-
-
84878933308
-
CR1 coding variant p.Ser1610Thr in Alzheimer disease and related endophenotypes
-
Van Cauwenberghe C, Bettens K, Engelborghs S, et al. CR1 coding variant p.Ser1610Thr in Alzheimer disease and related endophenotypes. Neurobiol Aging 2013, 34:2235.e1-2235.e6.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 2235.e1-2235.e6
-
-
Van Cauwenberghe, C.1
Bettens, K.2
Engelborghs, S.3
-
43
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva E, Meng Y, Lee JH, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007, 39:168-177.
-
(2007)
Nat Genet
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
-
44
-
-
84875661996
-
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
-
Miyashita A, Koike A, Jun G, et al. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One 2013, 8:e58618.
-
(2013)
PLoS One
, vol.8
-
-
Miyashita, A.1
Koike, A.2
Jun, G.3
-
45
-
-
33744965388
-
SorLA signaling by regulated intramembrane proteolysis
-
Bohm C, Seibel NM, Henkel B, Steiner H, Haass C, Hampe W SorLA signaling by regulated intramembrane proteolysis. J Biol Chem 2006, 281:14547-14553.
-
(2006)
J Biol Chem
, vol.281
, pp. 14547-14553
-
-
Bohm, C.1
Seibel, N.M.2
Henkel, B.3
Steiner, H.4
Haass, C.5
Hampe, W.6
-
46
-
-
0036869032
-
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA
-
Lintzel J, Franke I, Riedel IB, Schaller HC, Hampe W Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA. Biol Chem 2002, 383:1727-1733.
-
(2002)
Biol Chem
, vol.383
, pp. 1727-1733
-
-
Lintzel, J.1
Franke, I.2
Riedel, I.B.3
Schaller, H.C.4
Hampe, W.5
-
47
-
-
84922718986
-
Coding mutations in SORL1 and Alzheimer disease
-
Vardarajan BN, Zhang Y, Lee JH, et al. Coding mutations in SORL1 and Alzheimer disease. Ann Neurol 2015, 77:215-227.
-
(2015)
Ann Neurol
, vol.77
, pp. 215-227
-
-
Vardarajan, B.N.1
Zhang, Y.2
Lee, J.H.3
-
48
-
-
84875922261
-
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ε4, and the risk of late-onset Alzheimer disease in African Americans
-
Reitz C, Jun G, Naj A, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ε4, and the risk of late-onset Alzheimer disease in African Americans. JAMA 2013, 309:1483-1492.
-
(2013)
JAMA
, vol.309
, pp. 1483-1492
-
-
Reitz, C.1
Jun, G.2
Naj, A.3
-
49
-
-
85020160519
-
ABCA7 deletion associated with Alzheimer's disease in African Americans
-
for the Alzheimer Disease Genetics Consortium
-
Cukier HN, Kunkle BW, Rolati S, et al. ABCA7 deletion associated with Alzheimer's disease in African Americans. Alzheimers Dement 2015, 11(suppl):P485-P486. for the Alzheimer Disease Genetics Consortium.
-
(2015)
Alzheimers Dement
, vol.11
, pp. P485-P486
-
-
Cukier, H.N.1
Kunkle, B.W.2
Rolati, S.3
-
50
-
-
84937526438
-
Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study
-
Cuyvers E, De Roeck A, Van den Bossche T, et al. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study. Lancet Neurol 2015, 14:814-822.
-
(2015)
Lancet Neurol
, vol.14
, pp. 814-822
-
-
Cuyvers, E.1
De Roeck, A.2
Van den Bossche, T.3
-
51
-
-
84929432198
-
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
-
Steinberg S, Stefansson H, Jonsson T, et al. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. Nat Genet 2015, 47:445-447.
-
(2015)
Nat Genet
, vol.47
, pp. 445-447
-
-
Steinberg, S.1
Stefansson, H.2
Jonsson, T.3
-
52
-
-
84939654955
-
Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci
-
Vardarajan BN, Ghani M, Kahn A, et al. Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci. Ann Neurol 2015, 78:487-498.
-
(2015)
Ann Neurol
, vol.78
, pp. 487-498
-
-
Vardarajan, B.N.1
Ghani, M.2
Kahn, A.3
-
53
-
-
84908207773
-
The contribution of genetic variants to disease depends on the ruler
-
Witte JS, Visscher PM, Wray NR The contribution of genetic variants to disease depends on the ruler. Nat Rev Genet 2014, 15:765-776.
-
(2014)
Nat Rev Genet
, vol.15
, pp. 765-776
-
-
Witte, J.S.1
Visscher, P.M.2
Wray, N.R.3
-
55
-
-
84873031286
-
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
-
Lee SH, Harold D, Nyholt DR, et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet 2013, 22:832-841.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 832-841
-
-
Lee, S.H.1
Harold, D.2
Nyholt, D.R.3
-
56
-
-
32244435907
-
Role of genes and environments for explaining Alzheimer disease
-
Gatz M, Reynolds CA, Fratiglioni L, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 2006, 63:168-174.
-
(2006)
Arch Gen Psychiatry
, vol.63
, pp. 168-174
-
-
Gatz, M.1
Reynolds, C.A.2
Fratiglioni, L.3
-
57
-
-
79952489475
-
Estimating missing heritability for disease from genome-wide association studies
-
Lee SH, Wray NR, Goddard ME, Visscher PM Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011, 88:294-305.
-
(2011)
Am J Hum Genet
, vol.88
, pp. 294-305
-
-
Lee, S.H.1
Wray, N.R.2
Goddard, M.E.3
Visscher, P.M.4
-
58
-
-
36249023276
-
Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
-
Seshadri S, Wolf PA Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study. Lancet Neurol 2007, 6:1106-1114.
-
(2007)
Lancet Neurol
, vol.6
, pp. 1106-1114
-
-
Seshadri, S.1
Wolf, P.A.2
-
59
-
-
80052070571
-
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
-
Genin E, Hannequin D, Wallon D, et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 2011, 16:903-907.
-
(2011)
Mol Psychiatry
, vol.16
, pp. 903-907
-
-
Genin, E.1
Hannequin, D.2
Wallon, D.3
-
60
-
-
84889590173
-
Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia
-
Cuyvers E, Bettens K, Philtjens S, et al. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia. Neurobiol Aging 2014, 35:726-729.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 726-729
-
-
Cuyvers, E.1
Bettens, K.2
Philtjens, S.3
-
62
-
-
85020144222
-
Low-frequency variant imputation identifies rare variant candidate loci in a GWAS of late-onset Alzheimer disease in the IGAP Consortium
-
for The International Genomics of Alzheimer's Project (IGAP)
-
Kunkle B, Grenier-Boley B, Vronskaya M, et al. Low-frequency variant imputation identifies rare variant candidate loci in a GWAS of late-onset Alzheimer disease in the IGAP Consortium. Alzheimers Dement 2015, 11(suppl):P333-P334. for The International Genomics of Alzheimer's Project (IGAP).
-
(2015)
Alzheimers Dement
, vol.11
, pp. P333-P334
-
-
Kunkle, B.1
Grenier-Boley, B.2
Vronskaya, M.3
-
63
-
-
84873726158
-
Alzheimer's disease genes and cognition in the nondemented general population
-
Verhaaren BF, Vernooij MW, Koudstaal PJ, et al. Alzheimer's disease genes and cognition in the nondemented general population. Biol Psychiatry 2013, 73:429-434.
-
(2013)
Biol Psychiatry
, vol.73
, pp. 429-434
-
-
Verhaaren, B.F.1
Vernooij, M.W.2
Koudstaal, P.J.3
-
64
-
-
84898858439
-
Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions
-
Ebbert MT, Ridge PG, Wilson AR, et al. Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactions. Biol Psychiatry 2014, 75:732-737.
-
(2014)
Biol Psychiatry
, vol.75
, pp. 732-737
-
-
Ebbert, M.T.1
Ridge, P.G.2
Wilson, A.R.3
-
65
-
-
77958102016
-
Statistical analysis strategies for association studies involving rare variants
-
Bansal V, Libiger O, Torkamani A, Schork NJ Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet 2010, 11:773-783.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 773-783
-
-
Bansal, V.1
Libiger, O.2
Torkamani, A.3
Schork, N.J.4
-
66
-
-
84872057940
-
TREM2 variants in Alzheimer's disease
-
Guerreiro R, Wojtas A, Bras J, et al. TREM2 variants in Alzheimer's disease. N Engl J Med 2013, 368:117-127.
-
(2013)
N Engl J Med
, vol.368
, pp. 117-127
-
-
Guerreiro, R.1
Wojtas, A.2
Bras, J.3
-
67
-
-
84872088087
-
Variant of TREM2 associated with the risk of Alzheimer's disease
-
Jonsson T, Stefansson H, Steinberg S, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 2013, 368:107-116.
-
(2013)
N Engl J Med
, vol.368
, pp. 107-116
-
-
Jonsson, T.1
Stefansson, H.2
Steinberg, S.3
-
68
-
-
84938418325
-
What happens to microglial TREM2 in Alzheimer's disease: immunoregulatory turned into immunopathogenic?
-
Lue LF, Schmitz C, Walker DG What happens to microglial TREM2 in Alzheimer's disease: immunoregulatory turned into immunopathogenic?. Neuroscience 2015, 302:138-150.
-
(2015)
Neuroscience
, vol.302
, pp. 138-150
-
-
Lue, L.F.1
Schmitz, C.2
Walker, D.G.3
-
69
-
-
84904479732
-
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
-
243ra86
-
Kleinberger G, Yamanishi Y, Suarez-Calvet M, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med 2014, 6:243ra86.
-
(2014)
Sci Transl Med
, vol.6
-
-
Kleinberger, G.1
Yamanishi, Y.2
Suarez-Calvet, M.3
-
70
-
-
84902243410
-
Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2
-
Ulrich JD, Finn MB, Wang Y, et al. Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2. Mol Neurodegener 2014, 9:20.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 20
-
-
Ulrich, J.D.1
Finn, M.B.2
Wang, Y.3
-
71
-
-
84866368227
-
High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease
-
Pottier C, Hannequin D, Coutant S, et al. High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease. Mol Psychiatry 2012, 17:875-879.
-
(2012)
Mol Psychiatry
, vol.17
, pp. 875-879
-
-
Pottier, C.1
Hannequin, D.2
Coutant, S.3
-
72
-
-
84940054847
-
SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease
-
Nicolas G, Charbonnier C, Wallon D, et al. SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease. Mol Psychiatry 2016, 21:831-836.
-
(2016)
Mol Psychiatry
, vol.21
, pp. 831-836
-
-
Nicolas, G.1
Charbonnier, C.2
Wallon, D.3
-
73
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012, 488:96-99.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
-
74
-
-
84877618309
-
Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
-
Giraldo M, Lopera F, Siniard AL, et al. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiol Aging 2013, 34:2077.e11-2077.e18.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 2077.e11-2077.e18
-
-
Giraldo, M.1
Lopera, F.2
Siniard, A.L.3
-
75
-
-
84875261136
-
TREM2 is associated with the risk of Alzheimer's disease in Spanish population
-
Benitez BA, Cooper B, Pastor P, et al. TREM2 is associated with the risk of Alzheimer's disease in Spanish population. Neurobiol Aging 2013, 34:1711.e15-1711.e17.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 1711.e15-1711.e17
-
-
Benitez, B.A.1
Cooper, B.2
Pastor, P.3
-
76
-
-
84876398977
-
TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease
-
Pottier C, Wallon D, Rousseau S, et al. TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. J Alzheimers Dis 2013, 35:45-49.
-
(2013)
J Alzheimers Dis
, vol.35
, pp. 45-49
-
-
Pottier, C.1
Wallon, D.2
Rousseau, S.3
-
77
-
-
84892819277
-
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease
-
Cruchaga C, Karch CM, Jin SC, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 2014, 505:550-554.
-
(2014)
Nature
, vol.505
, pp. 550-554
-
-
Cruchaga, C.1
Karch, C.M.2
Jin, S.C.3
-
79
-
-
84926339944
-
PLD3 in non-familial Alzheimer's disease
-
Heilmann S, Drichel D, Clarimon J, et al. PLD3 in non-familial Alzheimer's disease. Nature 2015, 520:E3-E5.
-
(2015)
Nature
, vol.520
, pp. E3-E5
-
-
Heilmann, S.1
Drichel, D.2
Clarimon, J.3
-
80
-
-
84926293839
-
PLD3 gene variants and Alzheimer's disease
-
Hooli BV, Lill CM, Mullin K, et al. PLD3 gene variants and Alzheimer's disease. Nature 2015, 520:E7-E8.
-
(2015)
Nature
, vol.520
, pp. E7-E8
-
-
Hooli, B.V.1
Lill, C.M.2
Mullin, K.3
-
82
-
-
84923041272
-
Rarity of the Alzheimer disease-protective APP A673T variant in the United States
-
Wang LS, Naj AC, Graham RR, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 2015, 72:209-216.
-
(2015)
JAMA Neurol
, vol.72
, pp. 209-216
-
-
Wang, L.S.1
Naj, A.C.2
Graham, R.R.3
-
83
-
-
85058205674
-
Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease
-
Bamne MN, Demirci FY, Berman S, et al. Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease. Neurobiol Aging 2014, 35:1779.e15-1779.e16.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 1779.e15-1779.e16
-
-
Bamne, M.N.1
Demirci, F.Y.2
Berman, S.3
-
84
-
-
85058205844
-
Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals
-
Liu YW, He YH, Zhang YX, et al. Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals. Neurobiol Aging 2014, 35:935.e11-935.e12.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 935.e11-935.e12
-
-
Liu, Y.W.1
He, Y.H.2
Zhang, Y.X.3
-
85
-
-
84873454554
-
Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population
-
Kero M, Paetau A, Polvikoski T, et al. Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population. Neurobiol Aging 2013, 34:1518.e1-1518.e3.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 1518.e1-1518.e3
-
-
Kero, M.1
Paetau, A.2
Polvikoski, T.3
-
87
-
-
84988662285
-
Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
-
Bettens K, Vermeulen S, Van Cauwenberghe C, et al. Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations. Mol Neurodegener 2015, 10:30.
-
(2015)
Mol Neurodegener
, vol.10
, pp. 30
-
-
Bettens, K.1
Vermeulen, S.2
Van Cauwenberghe, C.3
-
88
-
-
84896360551
-
Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation
-
223ra20
-
Caglayan S, Takagi-Niidome S, Liao F, et al. Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med 2014, 6:223ra20.
-
(2014)
Sci Transl Med
, vol.6
-
-
Caglayan, S.1
Takagi-Niidome, S.2
Liao, F.3
-
89
-
-
84943279590
-
ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing
-
Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem 2015, 290:24152-24165.
-
(2015)
J Biol Chem
, vol.290
, pp. 24152-24165
-
-
Satoh, K.1
Abe-Dohmae, S.2
Yokoyama, S.3
St George-Hyslop, P.4
Fraser, P.E.5
-
90
-
-
84938912653
-
R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: clinical, genetic, and neuropathological study
-
Korvatska O, Leverenz JB, Jayadev S, et al. R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: clinical, genetic, and neuropathological study. JAMA Neurol 2015, 72:920-927.
-
(2015)
JAMA Neurol
, vol.72
, pp. 920-927
-
-
Korvatska, O.1
Leverenz, J.B.2
Jayadev, S.3
-
91
-
-
84884592445
-
Genic intolerance to functional variation and the interpretation of personal genomes
-
Petrovski S, Wang Q, Heinzen EL, Allen AS, Goldstein DB Genic intolerance to functional variation and the interpretation of personal genomes. PLoS Genet 2013, 9:e1003709.
-
(2013)
PLoS Genet
, vol.9
-
-
Petrovski, S.1
Wang, Q.2
Heinzen, E.L.3
Allen, A.S.4
Goldstein, D.B.5
-
93
-
-
84926191670
-
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
-
for the ODYSSEY LONG TERM Investigators
-
Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015, 372:1489-1499. for the ODYSSEY LONG TERM Investigators.
-
(2015)
N Engl J Med
, vol.372
, pp. 1489-1499
-
-
Robinson, J.G.1
Farnier, M.2
Krempf, M.3
-
94
-
-
84926206074
-
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
-
for the Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators
-
Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015, 372:1500-1509. for the Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators.
-
(2015)
N Engl J Med
, vol.372
, pp. 1500-1509
-
-
Sabatine, M.S.1
Giugliano, R.P.2
Wiviott, S.D.3
-
95
-
-
84930442437
-
Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia
-
Malik M, Chiles J, Xi HS, et al. Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia. Hum Mol Genet 2015, 24:3557-3570.
-
(2015)
Hum Mol Genet
, vol.24
, pp. 3557-3570
-
-
Malik, M.1
Chiles, J.2
Xi, H.S.3
-
96
-
-
84930332837
-
Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics
-
American College of Medical Genetics and Genomics Board of Directors
-
Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics. Genet Med 2015, 17:505-507. American College of Medical Genetics and Genomics Board of Directors.
-
(2015)
Genet Med
, vol.17
, pp. 505-507
-
-
-
97
-
-
84884979769
-
Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial
-
Mills SM, Mallmann J, Santacruz AM, et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris) 2013, 169:737-743.
-
(2013)
Rev Neurol (Paris)
, vol.169
, pp. 737-743
-
-
Mills, S.M.1
Mallmann, J.2
Santacruz, A.M.3
-
98
-
-
80055034288
-
Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments
-
Reiman EM, Langbaum JB, Fleisher AS, et al. Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J Alzheimers Dis 2011, 26(suppl 3):321-329.
-
(2011)
J Alzheimers Dis
, vol.26
, pp. 321-329
-
-
Reiman, E.M.1
Langbaum, J.B.2
Fleisher, A.S.3
-
99
-
-
79959193198
-
Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors
-
Goldman JS, Hahn SE, Catania JW, et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med 2011, 13:597-605.
-
(2011)
Genet Med
, vol.13
, pp. 597-605
-
-
Goldman, J.S.1
Hahn, S.E.2
Catania, J.W.3
-
100
-
-
84878012313
-
Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease
-
Rodriguez-Rodriguez E, Sanchez-Juan P, Vazquez-Higuera JL, et al. Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease. J Neural Transm 2013, 120:807-812.
-
(2013)
J Neural Transm
, vol.120
, pp. 807-812
-
-
Rodriguez-Rodriguez, E.1
Sanchez-Juan, P.2
Vazquez-Higuera, J.L.3
-
101
-
-
84911906938
-
Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach
-
Martiskainen H, Helisalmi S, Viswanathan J, et al. Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach. J Alzheimers Dis 2015, 43:565-573.
-
(2015)
J Alzheimers Dis
, vol.43
, pp. 565-573
-
-
Martiskainen, H.1
Helisalmi, S.2
Viswanathan, J.3
-
102
-
-
84952630745
-
A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Abeta
-
Sleegers K, Bettens K, De Roeck A, et al. A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Abeta. Alzheimers Dement 2015, 11:1452-1460.
-
(2015)
Alzheimers Dement
, vol.11
, pp. 1452-1460
-
-
Sleegers, K.1
Bettens, K.2
De Roeck, A.3
-
103
-
-
84925295495
-
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging
-
Chauhan G, Adams HH, Bis JC, et al. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiol Aging 2015, 36:1765.e7-1765.e16.
-
(2015)
Neurobiol Aging
, vol.36
, pp. 1765.e7-1765.e16
-
-
Chauhan, G.1
Adams, H.H.2
Bis, J.C.3
-
104
-
-
84934271687
-
Predicting Alzheimer's disease using combined imaging-whole genome SNP data
-
Kong D, Giovanello KS, Wang Y, et al. Predicting Alzheimer's disease using combined imaging-whole genome SNP data. J Alzheimers Dis 2015, 46:695-702.
-
(2015)
J Alzheimers Dis
, vol.46
, pp. 695-702
-
-
Kong, D.1
Giovanello, K.S.2
Wang, Y.3
-
105
-
-
84884508338
-
Incremental value of rare genetic variants for the prediction of multifactorial diseases
-
Mihaescu R, Pencina MJ, Alonso A, et al. Incremental value of rare genetic variants for the prediction of multifactorial diseases. Genome Med 2013, 5:76.
-
(2013)
Genome Med
, vol.5
, pp. 76
-
-
Mihaescu, R.1
Pencina, M.J.2
Alonso, A.3
-
106
-
-
84938510452
-
Personalized medicine for effective Alzheimer disease treatment
-
Kosik KS Personalized medicine for effective Alzheimer disease treatment. JAMA Neurol 2015, 72:497-498.
-
(2015)
JAMA Neurol
, vol.72
, pp. 497-498
-
-
Kosik, K.S.1
-
107
-
-
84946398793
-
Precision medicine: clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases
-
Montine TJ, Montine KS Precision medicine: clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases. J Exp Med 2015, 212:601-605.
-
(2015)
J Exp Med
, vol.212
, pp. 601-605
-
-
Montine, T.J.1
Montine, K.S.2
-
108
-
-
84896829795
-
A genotype-first approach to defining the subtypes of a complex disease
-
Stessman HA, Bernier R, Eichler EE A genotype-first approach to defining the subtypes of a complex disease. Cell 2014, 156:872-877.
-
(2014)
Cell
, vol.156
, pp. 872-877
-
-
Stessman, H.A.1
Bernier, R.2
Eichler, E.E.3
|