Genetic risk of Alzheimer's disease: Advising relatives

British Journal of Psychiatry

Volumn 178, Issue JAN., 2001, Pages 7-11

  Liddell, M B ^a   Lovestone, S ^a   Owen, M J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

ALZHEIMER DISEASE; AUTOSOMAL DOMINANT DISORDER; DEMENTIA; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DNA DETERMINATION; GENETIC COUNSELING; GENETIC EPIDEMIOLOGY; GENETIC RISK; GENOTYPE; LIFESPAN; PEDIGREE; REVIEW; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; GENETIC COUNSELING; GENETIC SCREENING; GENOTYPE; HUMANS; PEDIGREE; RISK FACTORS;

EID: 0035187434     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.178.1.7     Document Type: Review

References (40)

1. Prevalence of dementia and distribution of ApoE alleles in Japanese centenarians: An almost-complete survey in Yamanashi Prefecture, Japan
2. The role of heredity in late-onset Alzheimers disease and vascular dementia
3. Predictive testing for Huntington's disease: I Predictors of uptake in South Wales
4. Conjugal Alzheimer's disease: Is there an increased risk in offspring?
5. Prevalence of dementia in centenarians
6. Clinical genetics and genetic counselling in Alzheimer's disease
7. Age-dependent expression of familial risk in Alzheimer's disease
8. APOE-ε4 count predicts age when prevalence of AD increases, then declines: The Cache County Study
9. Medical and scientific committee Alzheimer's Disease International consensus statement on predictive testing
10. Early-onset autosomal dominant Alzheimer's disease: Prevalence, genetic heterogeneity, and mutation spectrum
11. Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease
12. If we all live long enough, will we all be demented?
13. Consensus report of the working group on 'Molecular and Biochemical Markers of AIzheimer's Disease'
14. Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease
15. The American College of Medical Genetics and American Society of Human Genetics: Statement on the use of apolipoprotein E testing for Alzheimer's disease
16. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease: A meta-analysis
17. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease
18. Prevalence of dementia in the 'oldest old' of a Dutch community
19. Apolipoprotein E allele ε4, dementia, and cognitive decline in a population sample
20. Dementia of the Alzheimer type: Clinical genetics, natural history, and associated conditions
21. Apolipoprotein E and the clinical features of late onset Alzheimer's disease
22. Variation in DCP I, encoding ACE, is associated with susceptibility to Alzheimer's disease
23. Apolipoprotein E ε4 allele, cognitive decline, and deterioration of everyday performance in Alzheimer's disease
24. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease
25. APOE genotype predicts when - Not whether - One is predisposed to develop Alzheimer's disease
26. Incidence and risk of dementia: The Rotterdam study
27. Apolipoprotein E4 alleles as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease
28. Is senile dementia 'age-related' or ageing-related? Evidence from meta-analysis of dementia prevalence in the oldest old
29. Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-I gene mutation
30. Genetic associations with human longevity at the APOE and ACE loci
31. Translating cell biology into therapeutic advances in Alzheimer's disease
32. Apolipoprotein E ε4 allele and the lifetime risk of Alzheimer's disease: What physicians know and what they should know
33. Lifetime risk of dementia and Alzheimer's disease: The impact of mortality on risk estimates in the Framingham study
34. Patterns of risk in first-degree relatives of patients with Alzheimer's disease
35. A population-based study of dementia in 85-year aids
36. The absence of an apolipoprotein ε4 allele is associated with a more aggressive form of Alzheimer's disease
37. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
38. The UK Alzheimer's disease genetics consortium
39. Ageing and the occurrence of dementia: Findings from a population-based cohort with a large sample of nonagenarians