Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals

Neurobiology of Aging

Volumn 35, Issue 4, 2014, Pages 935.e11-935.e12

  Liu, Yao Wen ^a,c,d   He, Yong Han ^a,c   Zhang, Yun Xia ^b   Cai, Wang Wei ^b   Yang, Li Qin ^a,c   Xu, Liang You ^e   Kong, Qing Peng ^a,c  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e Dujiangyan Longevity Research Centre   (China)

Author keywords

A673T; Alzheimer's disease; Amyloid precursor protein; Chinese; Longevity

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; APP GENE; ARTICLE; CHINESE; CONTROLLED STUDY; DNA DETERMINATION; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LONGEVITY; NEUROPROTECTION; NORMAL HUMAN; PRIORITY JOURNAL; VERY ELDERLY;

A673T; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; CHINESE; LONGEVITY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; HUMANS; LONGEVITY; MALE; MIDDLE AGED;

EID: 85058205844     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.09.023     Document Type: Article

References (11)

1. Brouwers N., Sleegers K., Van Broeckhoven C. Molecular genetics of Alzheimer's disease: an update. Ann. Med. 2008, 40:562-583.
2. Evert J., Lawler E., Bogan H., Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J.Gerontol. Biol. Sci. Med. Sci. 2003, 58:M232-M237.
3. Herskind A.M., McGue M., Holm N.V., Sörensen T.I., Harvald B., Vaupel J.W. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 1996, 97:319-323.
4. Jonsson T., Atwal J.K., Steinberg S., Snaedal J., Jonsson P.V., Bjornsson S., Stefansson H., Sulem P., Gudbjartsson D., Maloney J., Hoyte K., Gustafson A., Liu Y., Lu Y., Bhangale T., Graham R.R., Huttenlocher J., Bjornsdottir G., Andreassen O.A., Jönsson E.G., Palotie A., Behrens T.W., Magnusson O.T., Kong A., Thorsteinsdottir U., Watts R.J., Stefansson K. Amutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012, 488:96-99.
5. Kero M., Paetau A., Polvikoski T., Tanskanen M., Sulkava R., Jansson L., Myllykangas L., Tienari P.J. Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population. Neurobiol. Aging 2013, 34:1518.e1-1518.e3.
6. Plassman B.L., Langa K.M., Fisher G.G., Heeringa S.G., Weir D.R., Ofstedal M.B., Burke J.R., Hurd M.D., Potter G.G., Rodgers W.L., Steffens D.C., Willis R.J., Wallace R.B. Prevalence of dementia in the United States: the Aging, Demographics, and Memory Study. Neuroepidemiology 2007, 29:125-132.
7. Prince M., Jackson J. World Alzheimer Report 2009-Executive Summary. Alzheimer's Disease International 2009, 1-22. Available at. http://www.alz.co.uk/research/files/WorldAlzheimerReport-ExecutiveSummary.pdf.
8. Seng Ting S.K., Chong M.-S., Kandiah N., Hameed S., Tan L., Au W.-L., Prakash K.M., Pavanni R., Lee T.-S., Foo J.-N., Bei J.X., Yu X.Q., Liu J.J., Zhao Y., Lee W.L., Tan E.K. Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases. Neurobiol. Aging 2013, 34:2441.e7-2441.e8.
9. Exome Variant Server, NHLBI GO Exome Sequencing Project (ESP), Seattle, WA, 2012. Available at: http://evs.gs.washington.edu/EVS/.
10. Westendorp R.G., Van Heemst D., Rozing M.P., Frölich M., Mooijaart S.P., Blauw G.J., Beekman M., Heijmans B.T., De Craen A.J., Slagboom P.E., Leiden Longevity Study Group Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: the Leiden Longevity Study. J.Am. Geriatr. Soc. 2009, 57:1634-1637.
11. WHO. 2012. Dementia cases set to triple by 2050 but still largely ignored.Available at: http://www.who.int/mediacentre/news/releases/2012/dementia_20120411/en/.