Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

PLoS Pathogens

Volumn 12, Issue 5, 2016, Pages

  Mann, Paul A ^a   Müller, Anna ^b,c   Wolff, Kerstin A ^a   Fischmann, Thierry ^a   Wang, Hao ^a   Reed, Patricia ^d   Hou, Yan ^a   Li, Wenjin ^b   Müller, Christa E ^b   Xiao, Jianying ^a   Murgolo, Nicholas ^a   Sher, Xinwei ^a   Mayhood, Todd ^a   Sheth, Payal R ^a   Mirza, Asra ^a   Labroli, Marc ^a   Xiao, Li ^a   McCoy, Mark ^a   Gill, Charles J ^a   Pinho, Mariana G ^d   Schneider, Tanja ^b,c   Roemer, Terry ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c German Center for Infection Research (DZIF)   (Germany)

^d INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

2 EPIMERASE; ANTIBIOTIC AGENT; BETA LACTAM; CAP5P PROTEIN; EPIMERASE; IMIPENEM; MNAA PROTEIN; TEICHOIC ACID; TUNICAMYCIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLMANNOSAMINE; BACTERIAL PROTEIN; ISOMERASE;

ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIAL GENOME; BIOFILM; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIMERIZATION; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC COMPLEMENTATION; LOSS OF FUNCTION MUTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PROTEIN PURIFICATION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; ANIMAL; BIOSYNTHESIS; CELL WALL; CHEMISTRY; DISEASE MODEL; FLUORESCENCE MICROSCOPY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL SENSITIVITY TEST; NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS INFECTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BACTERIAL PROTEINS; BIOFILMS; CELL WALL; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, FLUORESCENCE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RACEMASES AND EPIMERASES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; TEICHOIC ACIDS;

EID: 84973279372     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005585     Document Type: Article

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