Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1767-1770

  Lee, Kyungae ^a   Campbell, Jennifer ^a   Swoboda, Jonathan G ^a   Cuny, Gregory D ^b   Walker, Suzanne ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Antibiotic; Bacteriostatic; Staphylococcus aureus; Structure activity relationship (SAR); Targocil; Triazoloquinazoline; Wall teichoic acids (WTAs)

Indexed keywords

1835F03; 1856A19; 1856K21; ANTIBIOTIC AGENT; POLYMER; TARGOCIL; TRIAZOLOQUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; WALL TEICHOIC ACID;

ANIMAL EXPERIMENT; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BACTERIOSTASIS; BIOSYNTHESIS; CATION EXCHANGE; CHLORINATION; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; SOLID PHASE EXTRACTION; STAPHYLOCOCCUS INFECTION; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; MICROBIAL SENSITIVITY TESTS; QUINAZOLINES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TEICHOIC ACIDS;

STAPHYLOCOCCUS AUREUS;

EID: 76649129529     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.036     Document Type: Article

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