Use of a Bacteriophage Lysin to Identify a Novel Target for Antimicrobial Development

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Schuch, Raymond ^a,f   Pelzek, Adam J ^a   Raz, Assaf ^a   Euler, Chad W ^a   Ryan, Patricia A ^a,b   Winer, Benjamin Y ^a   Farnsworth, Andrew ^c   Bhaskaran, Shyam S ^a   Stebbins, C Erec ^a   Xu, Yong ^d   Clifford, Adrienne ^d   Bearss, David J ^d,e   Vankayalapati, Hariprasad ^d,e   Goldberg, Allan R ^d,g   Fischetti, Vincent A ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c Fuller Evolutionary Biology Program   (United States)

^d ASTEX PHARMACEUTICALS   (United Kingdom)

^e UNIVERSITY OF UTAH   (United States)

^f ContraFect Corporation ^*  (United States)

^g Avacyn Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 EPIMERASE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; EPIMERASE; EPIMEROX; PLYG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHRAX; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFECTIVE AGENTS; BACILLUS ANTHRACIS; BACTERIOPHAGES; DNA PRIMERS; FEMALE; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MUCOPROTEINS; POLYMERASE CHAIN REACTION;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 84876059829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060754     Document Type: Article

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