TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Science Translational Medicine

Volumn 8, Issue 329, 2016, Pages

  Lee, Sang Ho ^a   Wang, Hao ^a   Labroli, Marc ^a   Koseoglu, Sandra ^a   Zuck, Paul ^a   Mayhood, Todd ^a   Gill, Charles ^a   Mann, Paul ^a   Sher, Xinwei ^a   Ha, Sookhee ^a   Yang, Shu Wei ^a   Mandal, Mihir ^a   Yang, Christine ^a   Liang, Lianzhu ^a   Tan, Zheng ^a   Tawa, Paul ^a   Hou, Yan ^a   Kuvelkar, Reshma ^a   De Vito, Kristine ^a   Wen, Xiujuan ^a   Xiao, Jing ^a   Batchlett, Michelle ^a   Balibar, Carl J ^a   Liu, Jenny ^a   Xiao, Jianying ^a   Murgolo, Nicholas ^a   Garlisi, Charles G ^a   Sheth, Payal R ^a   Flattery, Amy ^a   Su, Jing ^a   Tan, Christopher ^a   Roemer, Terry ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; DICLOXACILLIN; IMIPENEM; LINEZOLID; TAROCIN A; TAROCIN A2; TAROCIN B; TEICHOIC ACID; TUNICAMYCIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BETA LACTAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM ISOLATE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENTIATION; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL WALL; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR MODEL; PHENOTYPE; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

ANIMALS; BACTERIAL PROTEINS; BETA-LACTAMS; BIOSYNTHETIC PATHWAYS; CELL WALL; DICLOXACILLIN; FEMALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PHENOTYPE; STAPHYLOCOCCAL INFECTIONS; TEICHOIC ACIDS; TREATMENT OUTCOME;

EID: 84960425041     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aad7364     Document Type: Article

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