Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

Nature Structural and Molecular Biology

Volumn 23, Issue 7, 2016, Pages 647-655

  Densham, Ruth M ^a   Garvin, Alexander J ^a   Stone, Helen R ^a   Strachan, Joanna ^a,d   Baldock, Robert A ^b   Daza Martin, Manuel ^a   Fletcher, Alice ^a   Blair Reid, Sarah ^a   Beesley, James ^a   Johal, Balraj ^a   Pearl, Laurence H ^b   Neely, Robert ^a   Keep, Nicholas H ^c   Watts, Felicity Z ^b   Morris, Joanna R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; CAMPTOTHECIN; CISPLATIN; DNA; ETOPOSIDE; HETERODIMER; HISTONE H2AX; HYDROXYUREA; MYC PROTEIN; OLAPARIB; RECQ HELICASE; REPLICATION FACTOR A; SMALL INTERFERING RNA; SMARCAD1 PROTEIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; BARD1 PROTEIN, HUMAN; BRCA1 PROTEIN, HUMAN; CHROMATIN; DNA HELICASE; HISTONE; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN BINDING; RECOMBINANT PROTEIN; SMARCAD1 PROTEIN, HUMAN; TP53BP1 PROTEIN, HUMAN; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN;

ARTICLE; CANCER RESISTANCE; CHROMATIN; DNA REPAIR; ENZYME ACTIVITY; FEMALE; HELA CELL LINE; HISTONE UBIQUITINATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; DNA CLEAVAGE; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR MODEL; RECOMBINATION REPAIR; SIGNAL TRANSDUCTION; UBIQUITINATION;

BINDING SITES; BRCA1 PROTEIN; CAMPTOTHECIN; CHROMATIN; CLONING, MOLECULAR; DNA BREAKS, DOUBLE-STRANDED; DNA CLEAVAGE; DNA HELICASES; DNA, NEOPLASM; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HISTONES; HUMANS; MODELS, MOLECULAR; PHTHALAZINES; PIPERAZINES; PROTEIN BINDING; RECOMBINANT PROTEINS; RECOMBINATIONAL DNA REPAIR; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84973172373     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3236     Document Type: Article

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