Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

Journal of Clinical Investigation

Volumn 126, Issue 6, 2016, Pages 2191-2204

  Cole, David K ^a   Bulek, Anna M ^a   Dolton, Garry ^a   Schauenberg, Andrea J ^a   Szomolay, Barbara ^a,b   Rittase, William ^c   Trimby, Andrew ^a   Jothikumar, Prithiviraj ^c   Fuller, Anna ^a   Skowera, Ania ^d,e   Rossjohn, Jamie ^a,f   Zhu, Cheng ^c,g   Miles, John J ^a,h   Peakman, Mark ^d,e   Wooldridge, Linda ⁱ   Rizkallah, Pierre J ^a   Sewell, Andrew K ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^f MONASH UNIVERSITY   (Australia)

^g GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^h QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

ⁱ UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERED PEPTIDE LIGAND; LIGAND; PREPROINSULIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; HLA A ANTIGEN; INSULIN; LYMPHOCYTE ANTIGEN RECEPTOR; OLIGOPEPTIDE; PROTEIN BINDING; PROTEIN PRECURSOR;

ARTICLE; AUTOIMMUNITY; BACTEROIDES THETAIOTAOMICRON; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CELL CLONE; CLOSTRIDIUM; CLOSTRIDIUM ASPARAGIFORME; CONTROLLED STUDY; CROSS REACTION; ENTHALPY; ENTROPY; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; IMMUNOLOGY; KINETICS; METABOLISM; MOLECULAR MODEL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; AUTOIMMUNITY; CLONE CELLS; CROSS REACTIONS; HLA-A ANTIGENS; HUMANS; INSULIN; KINETICS; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN PRECURSORS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 84973164846     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI85679     Document Type: Article

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