Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers

Scientific Reports

Volumn 2, Issue , 2012, Pages

  Holland, Christopher J ^a   Rizkallah, Pierre J ^a   Vollers, Sabrina ^b   Calvo Calle, J Mauricio ^b   Madura, Florian ^a   Fuller, Anna ^a   Sewell, Andrew K ^a   Stern, Lawrence J ^b   Godkin, Andrew ^a,c   Cole, David K ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; CROSS REACTION; HUMAN; HYDROGEN BOND; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; T LYMPHOCYTE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CELLS, CULTURED; CROSS REACTIONS; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HLA-DR1 ANTIGEN; HLA-DR4 ANTIGEN; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; THERMODYNAMICS;

EID: 84866070726     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00629     Document Type: Article

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