Distortion of the major histocompatibility complex class i binding groove to accommodate an insulin-derived 10-mer peptide

Journal of Biological Chemistry

Volumn 290, Issue 31, 2015, Pages 18924-18933

  Motozono, Chihiro ^a,b   Pearson, James A ^a   De Leenheer, Evy ^a   Rizkallah, Pierre J ^a   Beck, Konrad ^c   Trimby, Andrew ^a   Sewell, Andrew K ^a   Wong, F Susan ^a   Cole, David K ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; INSULIN;

BINDING MODES; BINDING POCKETS; C-TERMINAL PEPTIDES; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS; MHC PEPTIDE; TYPE 1 DIABETES;

PEPTIDES;

EPITOPE; INSULIN; INSULIN PEPTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 1; PEPTIDE FRAGMENT; PROTEIN BINDING;

ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; NONOBESE DIABETIC MOUSE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; BINDING SITES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 1; HISTOCOMPATIBILITY ANTIGENS CLASS I; INSULIN; MICE, INBRED NOD; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS;

EID: 84940541934     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.622522     Document Type: Article

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