Identification of a crucial energetic footprint on the α1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by Tax peptide/HLA-A2-specific T cell receptors

Journal of Experimental Medicine

Volumn 193, Issue 5, 2001, Pages 551-562

  Baker, Brian M ^a   Turner, Richard V ^c   Gagnon, Susan J ^c   Wiley, Don C ^a,b   Biddison, William E ^c,d  

^a HARVARD UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Binding kinetics; CD8+T cell; Major histocompatibility complex class I peptide complex; T cell activation; T cell receptor

Indexed keywords

HLA A2 ANTIGEN; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TAX PROTEIN;

ALPHA HELIX; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL LINE; CONTROLLED STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; T LYMPHOCYTE ACTIVATION;

ALANINE; AMINO ACID SUBSTITUTION; ANTIGEN PRESENTATION; BINDING SITES; CELL LINE; CIRCULAR DICHROISM; GENE PRODUCTS, TAX; HLA-A2 ANTIGEN; HUMANS; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ANTIGEN, T-CELL; TEMPERATURE;

EID: 0035809315     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.5.551     Document Type: Article

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