Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

Journal of Immunology

Volumn 194, Issue 1, 2015, Pages 463-474

  Tungatt, Katie ^a   Bianchi, Valentina ^a   Crowther, Michael D ^a   Powell, Wendy E ^a   Schauenburg, Andrea J ^a   Trimby, Andrew ^a   Donia, Marco ^b   Miles, John J ^a,c   Holland, Christopher J ^a   Cole, David K ^a   Godkin, Andrew J ^a   Peakman, Mark ^d   Straten, Per Thor ^b   Svane, Inge Marie ^b   Sewell, Andrew K ^a   Dolton, Garry ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPHYCOCYANIN; ANTIBODY; FLUORESCEIN ISOTHIOCYANATE; FLUOROCHROME CONJUGATED ANTIBODY; FLUOROCHROME CONJUGATED PEPTIDE MAJOR HISTOCOMPATIBILITY ANTIGEN MULTIMER; FLUOROCHROME UNCONJUGATED ANTIBODY; PROTEIN KINASE INHIBITOR; REAGENT; T LYMPHOCYTE RECEPTOR; TETRAMER; UNCLASSIFIED DRUG; FLUORESCENT DYE; LYMPHOCYTE ANTIGEN RECEPTOR; PHYCOCYANIN; PROTEIN BINDING;

ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; DISSOCIATION; FLUOROCHROME STAINING; HUMAN; HUMAN CELL; MOLECULAR STABILITY; RECEPTOR BINDING; T LYMPHOCYTE; CELL CULTURE; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; PROCEDURES; STAINING;

ANTIBODIES; CELLS, CULTURED; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; HUMANS; PHYCOCYANIN; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RECEPTORS, ANTIGEN, T-CELL; STAINING AND LABELING; T-LYMPHOCYTES;

EID: 84919681010     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401785     Document Type: Article

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