A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Journal of Molecular Biology

Volumn 428, Issue 3, 2016, Pages 538-553

  Jiang, Li ^a   Liu, Ping ^a   Bank, Claudia ^b   Renzette, Nicholas ^a   Prachanronarong, Kristina ^a   Yilmaz, Lutfu S ^a   Caffrey, Daniel R ^a   Zeldovich, Konstantin B ^a   Schiffer, Celia A ^a   Kowalik, Timothy F ^a   Jensen, Jeffrey D ^b   Finberg, Robert W ^a   Wang, Jennifer P ^a   Bolon, Daniel N A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b EPFL   (Switzerland)

Author keywords

adaptive; experimental fitness; neuraminidase inhibitor; oseltamivir; systematic mutation

Indexed keywords

OSELTAMIVIR; SIALIDASE; ANTIVIRUS AGENT; ENZYME INHIBITOR; VIRUS PROTEIN;

ARTICLE; DRUG BINDING; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; INFLUENZA A; INFLUENZA A VIRUS (H1N1); NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; VIRUS STRAIN; ANIMAL; ANTIVIRAL RESISTANCE; CELL LINE; CHEMICAL STRUCTURE; DOG; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; INFLUENZA A VIRUS; INFLUENZA, HUMAN; METABOLISM; ORTHOMYXOVIRIDAE INFECTIONS; POINT MUTATION; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOGS; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MODELS, MOLECULAR; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; POINT MUTATION; VIRAL PROTEINS;

EID: 84958759356     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.11.027     Document Type: Article

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