Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis

Oncotarget

Volumn 7, Issue 12, 2016, Pages 13285-13296

  O'Hagan Wong, Kelsey ^a   Nadeau, Stéphanie ^b   Carrier Leclerc, Audrey ^b   Apablaza, Felipe ^a   Hamdy, Reggie ^a   Shum Tim, Dominique ^a   Rodier, Francis ^b,c   Colmegna, Inés ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Institut du Cancer de Montreal   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Aging; Gerotarget; Hematopoietic stem and progenitor cells; Mesenchymal stromal cells; Senescence; Senescence associated secretory phenotype

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; DNA; INTERLEUKIN 6; INTERLEUKIN 8; BIOLOGICAL MARKER; IL6 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DAMAGE; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MESENCHYMAL STROMA CELL; MIDDLE AGED; SENESCENCE; SIGNAL TRANSDUCTION; STEM CELL EXPANSION; APOPTOSIS; CELL AGING; CELL CULTURE; CYTOLOGY; HEMATOPOIESIS; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ADOLESCENT; ANTIGENS, CD34; APOPTOSIS; BIOMARKERS; CELL PROLIFERATION; CELLS, CULTURED; CELLULAR SENESCENCE; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-6; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED;

EID: 84971607476     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7690     Document Type: Article

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