The effect of age on human adipose-derived stem cells

Plastic and Reconstructive Surgery

Volumn 131, Issue 1, 2013, Pages 27-37

  Wu, Wei ^a   Niklason, Laura ^a   Steinbacher, Derek M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; OSTEOCALCIN; RUNX2 PROTEIN, HUMAN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR RUNX2;

ABDOMINAL SUBCUTANEOUS FAT; ADULT; AGED; AGING; ANGIOGENESIS; ARTICLE; BONE DEVELOPMENT; CELL AGING; CELL CULTURE; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; HUMAN; INFANT; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TELOMERE;

ADULT; AGED; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; CELL AGING; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FLOW CYTOMETRY; HUMANS; INFANT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOCALCIN; OSTEOGENESIS; REAL-TIME POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT, ABDOMINAL; TELOMERE;

EID: 84872068303     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e3182729cfc     Document Type: Article

References (37)

1. Cherubino M, Rubin JP, Miljkovic N, Kelmendi-Doko A, Marra KG. Adipose-derived stem cells for wound healing applications. Ann Plast Surg. 2011;66:210-215.
2. Tiryaki T, Findikli N, Tiryaki D. Staged stem cell-enriched tissue (SET) injections for soft tissue augmentation in hostile recipient areas: A preliminary report. Aesthetic Plast Surg. 2011;35:965-971.
3. Levi B, James AW, Nelson ER, et al. Studies in adiposederived stromal cells: Migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 2011;127:1130-1140.
4. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279- 4295.
5. Yu G, Floyd ZE, Wu X, Halvorsen YD, Gimble JM. Isolation of human adipose-derived stem cells from lipoaspirates. Methods Mol Biol. 2011;702:17-27.
6. Gimble JM, Bunnell BA, Guilak F. Human adipose-derived cells: An update on the transition to clinical translation. Regen Med. 2012;7:225-235.
7. Wall ME, Bernacki SH, Loboa EG. Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells. Tissue Eng. 2007;13:1291-1298.
8. Kern S, Eichler H, Stoeve J, Klu?ter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294- 1301.
9. Cheung WK, Working DM, Galuppo LD, Leach JK. Osteogenic comparison of expanded and uncultured adipose stromal cells. Cytotherapy 2010;12:554-562.
10. Mesima?ki K, Lindroos B, To?rnwall J, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg. 2009;38:201-209.
11. Levi B, Hyun JS, Nelson ER, et al. Nonintegrating knockdown and customized scaffold design enhances human adipose- derived stem cells in skeletal repair. Stem Cells 2011; 29:2018-2029.
12. Eto H, Suga H, Inoue K, et al. Adipose injury-associated factors mitigate hypoxia in ischemic tissues through activation of adipose-derived stem/progenitor/stromal cells and induction of angiogenesis. Am J Pathol. 2011;178:2322-2332.
13. Conejero JA, Lee JA, Parrett BM, et al. Repair of palatal bone defects using osteogenically differentiated fat-derived stem cells. Plast Reconstr Surg. 2006;117:857-863.
14. Sethe S, Scutt A, Stolzing A. Aging of mesenchymal stem cells. Ageing Res Rev. 2006;5:91-116.
15. Maslov AY, Barone TA, Plunkett RJ, Pruitt SC. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci. 2004;24:1726- 1733.
16. Campisi J. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 2005;120:513- 522.
17. Markel TA, Crisostomo PR, Manukyan MC, et al. Are neonatal stem cells as effective as adult stem cells in providing ischemic protection? J Surg Res. 2009;152:325-330.
18. Jiang Y, Mishima H, Sakai S, Liu Y-k, Ohyabu, Y, Uemura T. Gene expression analysis of major lineage-defining factors in human bone marrow cells: Effect of aging, gender, and agerelated disorders. J Orthop Res. 2008;26:910-917.
19. Shi YY, Nacamuli RP, Salim A, Longaker MT. The osteogenic potential of adipose-derived mesenchymal cells is maintained with aging. Plast Reconstr Surg. 2005;116:1686-1696.
20. Chen HT, Lee MJ, Chen CH, et al. Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med. 2012;16:582-593.
21. Levi B, Nelson ER, Li S, et al. Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells 2011;29:1241-1255.
22. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.
23. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T)method. Nat Protoc. 2008;3:1101-1108.
24. Stolzing A, Jones E, McGonagle D, Scutt A. Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies. Mech Ageing Dev. 2008; 129:163-173.
25. Zhou S, Greenberger JS, Epperly MW, et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 2008;7:335-343.
26. Wilson SM, Goldwasser MS, Clark SG, et al. Adipose-derived mesenchymal stem cells enhance healing of mandibular defects in the ramus of swine. J Oral Maxillofac Surg. 2012;70: e193-e203.
27. Asumda FZ, Chase PB. Age-related changes in rat bonemarrow mesenchymal stem cell plasticity.BMCCell Biol. 2011; 12:44.
28. Hacia JG, Lee CC, Jimenez DF, et al. Age-related gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cells. J Cell Biochem. 2008;103:1198-1210.
29. Maijenburg MW, Kleijer M, Vermeul K, et al. The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging. Haematologica 2012;97:179-183.
30. Backly RM, Cancedda R. Bone marrow stem cells in clinical application: Harnessing paracrine roles and niche mechanisms. Adv Biochem Eng Biotechnol. 2010;123:265-292.
31. Salgado AJ, Reis RL, Sousa NJ, Gimble JM. Adipose tissue derived stem cells secretome: Soluble factors and their roles in regenerative medicine. Curr Stem Cell Res Ther. 2010;5: 103-110.
32. Nakanishi C, Nagaya N, Ohnishi S, et al. Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow. Circ J. 2011;75:2260- 2268.
33. Sowa Y, Imura T, Numajiri T, Nishino K, Fushiki S. Adiposederived stem cells produce factors enhancing peripheral nerve regeneration: Influence of age and anatomic site of origin. Stem Cells Dev. 2012;21:1852-1862.
34. Lee K, Kim H, Kim JM, et al. Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function. J Cell Mol Med. 2011;15:2082-2094.
35. Kilroy GE, Foster SJ, Wu X, et al. Cytokine profile of human adipose-derived stem cells: Expression of angiogenic, hematopoietic, and pro-inflammatory factors. J Cell Physiol. 2007; 212:702-709.
36. Nishikawa K, Nakashima T, Takeda S, et al. Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest. 2010;120:3455-3465.
37. Tsai CC, Chen YJ, Yew TL, et al. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. Blood 2011;117: 459-469.