Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis

Clinical Immunology

Volumn 143, Issue 1, 2012, Pages 73-82

  Colmegna, Inés ^a,b   Pryshchep, Sergey ^a,c   Oishi, Hisashi ^a,d   Goronzy, Jörg J ^a   Weyand, Cornelia M ^a  

^a STANFORD UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

CD34; ERK signaling; Hematopoietic progenitor cells; Rheumatoid arthritis; STAT signaling

Indexed keywords

B RAF KINASE; CD34 ANTIGEN; CELL CYCLE PROTEIN; CELL SURFACE RECEPTOR; FLT3 LIGAND; INTERLEUKIN 3; INTERLEUKIN 6; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; STAT3 PROTEIN; STAT5 PROTEIN; STEM CELL FACTOR;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; STEM CELL EXPANSION;

ANTIGENS, CD34; ARTHRITIS, RHEUMATOID; CELL PROLIFERATION; CYCLINS; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLOW CYTOMETRY; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION PROFILING; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-6 RECEPTOR ALPHA SUBUNIT; MALE; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, CONFOCAL; MIDDLE AGED; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR;

EID: 84858079013     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2012.01.007     Document Type: Article

References (45)

1. Gorman C.L., Cope A.P. Immune-mediated pathways in chronic inflammatory arthritis. Best Pract. Res. Clin. Rheumatol. 2008, 22:221-238.
2. Goronzy J.J., Weyand C.M. Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res. Ther. 2009, 11:249.
3. Colmegna I., Diaz-Borjon A., Fujii H., Schaefer L., Goronzy J.J., Weyand C.M. Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum. 2008, 58:990-1000.
4. Martinez-Agosto J.A., Mikkola H.K., Hartenstein V., Banerjee U. The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 2007, 21:3044-3060.
5. Metcalf D. Hematopoietic cytokines. Blood 2008, 111:485-491.
6. Snowden J.A., Nink V., Cooley M., Zaunders J., Keir M., Wright L., Milliken S.T., Brooks P.M., Biggs J.C. Composition and function of peripheral blood stem and progenitor cell harvests from patients with severe active rheumatoid arthritis. Br. J. Haematol. 1998, 103:601-609.
7. Porta C., Caporali R., Epis O., Ramaioli I., Invernizzi R., Rovati B., Comolli G., Danova M., Montecucco C. Impaired bone marrow hematopoietic progenitor cell function in rheumatoid arthritis patients candidated to autologous hematopoietic stem cell transplantation. Bone Marrow Transplant. 2004, 33:721-728.
8. Papadaki H.A., Marsh J.C., Eliopoulos G.D. Bone marrow stem cells and stromal cells in autoimmune cytopenias. Leuk. Lymphoma 2002, 43:753-760.
9. Ruger B., Giurea A., Wanivenhaus A.H., Zehetgruber H., Hollemann D., Yanagida G., Groger M., Petzelbauer P., Smolen J.S., Hoecker P., Fischer M.B. Endothelial precursor cells in the synovial tissue of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 2004, 50:2157-2166.
10. Hughes L.B., Reynolds R.J., Brown E.E., Kelley J.M., Thomson B., Conn D.L., Jonas B.L., Westfall A.O., Padilla M.A., Callahan L.F., Smith E.A., Brasington R.D., Edberg J.C., Kimberly R.P., Moreland L.W., Plenge R.M., Bridges S.L. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis Rheum. 2010, 62:3547-3553.
11. Perez O.D., Nolan G.P. Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level. Immunol. Rev. 2006, 210:208-228.
12. Bradley H.L., Hawley T.S., Bunting K.D. Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells. Blood 2002, 100:3983-3989.
13. Chambers S.M., Shaw C.A., Gatza C., Fisk C.J., Donehower L.A., Goodell M.A. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007, 5:e201.
14. Rossi D.J., Jamieson C.H., Weissman I.L. Stems cells and the pathways to aging and cancer. Cell 2008, 132:681-696.
15. Weyand C.M., Fujii H., Shao L., Goronzy J.J. Rejuvenating the immune system in rheumatoid arthritis. Nat. Rev. Rheumatol. 2009, 5:583-588.
16. Tajima S., Tsuji K., Ebihara Y., Sui X., Tanaka R., Muraoka K., Yoshida M., Yamada K., Yasukawa K., Taga T., Kishimoto T., Nakahata T. Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells. J. Exp. Med. 1996, 184:1357-1364.
17. Yu Q., Ciemerych M.A., Sicinski P. Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins. Oncogene 2005, 24:7114-7119.
18. Murphy M.J., Wilson A., Trumpp A. More than just proliferation: Myc function in stem cells. Trends Cell Biol. 2005, 15:128-137.
19. Woost P.G., Solchaga L.A., Meyerson H.J., Shankey T.V., Goolsby C.L., Jacobberger J.W. High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow. Blood 2011, 117:e131-141.
20. Miranda M.B., Xu H., Torchia J.A., Johnson D.E. Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk. Res. 2005, 29:1293-1306.
21. Shelton J.G., Steelman L.S., Lee J.T., Knapp S.L., Blalock W.L., Moye P.W., Franklin R.A., Pohnert S.C., Mirza A.M., McMahon M., McCubrey J.A. Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene 2003, 22:2478-2492.
22. Chang F., Steelman L.S., Lee J.T., Shelton J.G., Navolanic P.M., Blalock W.L., Franklin R.A., McCubrey J.A. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 2003, 17:1263-1293.
23. Ronnstrand L. Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol. Life Sci. 2004, 61:2535-2548.
24. Si J., Collins S.J. IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner. Blood 2002, 100:4401-4409.
25. Kenworthy A.K. Nanoclusters digitize Ras signalling. Nat. Cell Biol. 2007, 9:875-877.
26. McCubrey J.A., Steelman L.S., Chappell W.H., Abrams S.L., Wong E.W., Chang F., Lehmann B., Terrian D.M., Milella M., Tafuri A., Stivala F., Libra M., Basecke J., Evangelisti C., Martelli A.M., Franklin R.A. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim. Biophys. Acta 2007, 1773:1263-1284.
27. Tian T., Harding A., Inder K., Plowman S., Parton R.G., Hancock J.F. Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nat. Cell Biol. 2007, 9:905-914.
28. Schonland S.O., Lopez C., Widmann T., Zimmer J., Bryl E., Goronzy J.J., Weyand C.M. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:13471-13476.
29. Fujii H., Shao L., Colmegna I., Goronzy J.J., Weyand C.M. Telomerase insufficiency in rheumatoid arthritis. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:4360-4365.
30. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
31. Lyman S.D., Jacobsen S.E. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 1998, 91:1101-1134.
32. McKenna H.J., Stocking K.L., Miller R.E., Brasel K., De Smedt T., Maraskovsky E., Maliszewski C.R., Lynch D.H., Smith J., Pulendran B., Roux E.R., Teepe M., Lyman S.D., Peschon J.J. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000, 95:3489-3497.
33. Thoren L.A., Liuba K., Bryder D., Nygren J.M., Jensen C.T., Qian H., Antonchuk J., Jacobsen S.E. Kit regulates maintenance of quiescent hematopoietic stem cells. J. Immunol. 2008, 180:2045-2053.
34. Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111.
35. Coppo P., Dusanter-Fourt I., Millot G., Nogueira M.M., Dugray A., Bonnet M.L., Mitjavila-Garcia M.T., Le Pesteur D., Guilhot F., Vainchenker W., Sainteny F., Turhan A.G. Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells. Oncogene 2003, 22:4102-4110.
36. Ando K., Ajchenbaum-Cymbalista F., Griffin J.D. Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:9571-9575.
37. Katz M., Amit I., Yarden Y. Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim. Biophys. Acta 2007, 1773:1161-1176.
38. Balmanno K., Cook S.J. Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ. 2009, 16:368-377.
39. Milella M., Konopleva M., Precupanu C.M., Tabe Y., Ricciardi M.R., Gregorj C., Collins S.J., Carter B.Z., D'Angelo C., Petrucci M.T., Foa R., Cognetti F., Tafuri A., Andreeff M. MEK blockade converts AML differentiating response to retinoids into extensive apoptosis. Blood 2007, 109:2121-2129.
40. Kornblau S.M., Womble M., Qiu Y.H., Jackson C.E., Chen W., Konopleva M., Estey E.H., Andreeff M. Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood 2006, 108:2358-2365.
41. Yamamoto T., Ebisuya M., Ashida F., Okamoto K., Yonehara S., Nishida E. Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression. Curr. Biol. 2006, 16:1171-1182.
42. Singh K., Deshpande P., Pryshchep S., Colmegna I., Liarski V., Weyand C.M., Goronzy J.J. ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. J. Immunol. 2009, 183:8258-8267.
43. Bluml S., Binder N.B., Niederreiter B., Polzer K., Hayer S., Tauber S., Schett G., Scheinecker C., Kollias G., Selzer E., Bilban M., Smolen J.S., Superti-Furga G., Redlich K. Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum. 2010, 62:1608-1619.
44. Shao L., Goronzy J.J., Weyand C.M. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol. Med. 2010, 2:415-427.
45. Shao L., Fujii H., Colmegna I., Oishi H., Goronzy J.J., Weyand C.M. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J. Exp. Med. 2009, 206:1435-1449.