Novel Benzo[a]quinolizidine Analogs Induce Cancer Cell Death through Paraptosis and Apoptosis

Journal of Medicinal Chemistry

Volumn 59, Issue 10, 2016, Pages 5063-5076

  Zheng, Hongbo ^a   Dong, Yiwen ^b   Li, Lin ^a   Sun, Bin ^a,c   Liu, Lei ^a   Yuan, Huiqing ^b   Lou, Hongxiang ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b Ningbo Addiction Research and Treatment Center   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; BENZO[A]QUINOLIZINE DERIVATIVE; CASPASE; QUINOLIZIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IN VITRO STUDY; MTT ASSAY; PARAPTOSIS; STRUCTURE ACTIVITY RELATION; UPREGULATION; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; MOUSE; NEOPLASM; PATHOLOGY; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MOLECULAR STRUCTURE; NEOPLASMS; QUINOLIZIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84971595586     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00484     Document Type: Article

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