A novel derivative of riccardin D induces cell death through lysosomal rupture in vitro and inhibits tumor growth in vivo

Cancer Letters

Volumn 329, Issue 2, 2013, Pages 207-216

  Wang, Yanyan ^a   Wang, Lining ^a   Hu, Zhongyi ^a   Ji, Yuan ^a   Lin, Zhaomin ^a   Yuan, Huiqing ^a   Ji, Mei ^a   Lou, Hongxiang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Bisbibenzyl; Cathepsin; Lysosome; Necrosis

Indexed keywords

ALPHA TUBULIN; AMINOMETHYLATED RICCARDIN D; ANTINEOPLASTIC AGENT; BENZYL DERIVATIVE; BETA ACTIN; CASPASE; CATHEPSIN B; ETOPOSIDE; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RICCARDIN D; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL DAMAGE; CELL SWELLING; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME RELEASE; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOMAL RUPTURE; MALE; MOUSE; NONHUMAN; ONCOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN CLEAVAGE; PROTEIN SECRETION; TUMOR VOLUME; TUMOR WEIGHT; WEIGHT REDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOSKELETAL PROTEINS; CYTOSKELETON; ETOPOSIDE; HUMANS; INHIBITORY CONCENTRATION 50; LYSOSOMES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NECROSIS; PHENYL ETHERS; STILBENES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84872487402     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.10.042     Document Type: Article

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