Emodin bidirectionally modulates macrophage polarization and epigenetically regulates macrophage memory

Journal of Biological Chemistry

Volumn 291, Issue 22, 2016, Pages 11491-11503

  Iwanowycz, Stephen ^a   Wang, Junfeng ^a   Altomare, Diego ^b   Hui, Yvonne ^a   Fan, Daping ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; ANTIGEN-ANTIBODY REACTIONS; CELL SIGNALING; GENES; PATHOLOGY; POLARIZATION; POLYMERASE CHAIN REACTION; TRANSCRIPTION;

ANTI-INFLAMMATORIES; CHROMATIN IMMUNOPRECIPITATION; FUNCTIONAL ASSAYS; GENE TRANSCRIPTIONS; HISTONE MODIFICATION; MACROPHAGE PHENOTYPES; QUANTITATIVE REAL TIME PCR; SIGNALING PATHWAYS;

MACROPHAGES;

EMODIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; NITRIC OXIDE; STAT1 PROTEIN; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR-4;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL ISOLATION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; POLARIZATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL POLARITY; CYTOLOGY; DRUG EFFECTS; EPIGENETICS; GENETICS; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INFLAMMATION; MACROPHAGE;

ANIMALS; CELL POLARITY; CELLS, CULTURED; EMODIN; EPIGENOMICS; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION; INTERFERON REGULATORY FACTORS; INTERLEUKIN-4; MACROPHAGES; MICE; MICE, INBRED C57BL; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84971367760     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.702092     Document Type: Article

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