Endogenous B-ring oxysterols inhibit the hedgehog component smoothened in a manner distinct from cyclopamine or side-chain oxysterols

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 21, 2016, Pages 5904-5909

  Sever, Navdar ^a   Mann, Randall K ^a   Xu, Libin ^b   Snell, William J ^c   Hernandez Lara, Carmen I ^c   Porter, Ned A ^b   Beachy, Philip A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Cyclodextrin; DHCEO; Hedgehog signaling; SLOS; Smoothened

Indexed keywords

3BETA,5ALPHA DIHYDROXYCHOLEST 7 EN 6 ONE; 5ALPHA,8ALPHA EPIDIOXY ERGOSTA 6,22 DIEN 3BETA OL; 7 DEHYDROCHOLESTEROL; ALPHA CYCLODEXTRIN; CYCLOPAMINE; ENDOPEROXIDE; ERGOSTEROL; METHYL BETA CYCLODEXTRIN; OXYSTEROL; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; 7-DEHYDROCHOLESTEROL; BETA CYCLODEXTRIN DERIVATIVE; METHYL-BETA-CYCLODEXTRIN; SMO PROTEIN, HUMAN; SMO PROTEIN, MOUSE; VERATRUM ALKALOID;

ARTICLE; CHLAMYDOMONAS REINHARDTII; ENZYME INHIBITION; ENZYME MECHANISM; FLAGELLUM; HEDGEHOG; LIPID ANALYSIS; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; SMITH LEMLI OPITZ SYNDROME; 3T3 CELL LINE; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE;

ANIMALS; BETA-CYCLODEXTRINS; CHLAMYDOMONAS REINHARDTII; DEHYDROCHOLESTEROLS; FLAGELLA; HEDGEHOG PROTEINS; HEK293 CELLS; HUMANS; MICE; NIH 3T3 CELLS; SIGNAL TRANSDUCTION; SMITH-LEMLI-OPITZ SYNDROME; SMOOTHENED RECEPTOR; VERATRUM ALKALOIDS;

EID: 84969895402     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1604984113     Document Type: Article

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