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Volumn 65, Issue 6, 2016, Pages 1534-1555

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CARRIER PROTEIN; GLUCOSE; INSULIN; MITONEET PROTEIN; PARKIN; UNCLASSIFIED DRUG; GLUCAGON; IRON BINDING PROTEIN; MEMBRANE PROTEIN; MITONEET PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

EID: 84969821656     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1323     Document Type: Article
Times cited : (58)

References (70)
  • 1
    • 33644872401 scopus 로고    scopus 로고
    • In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
    • Maechler P, Carobbio S, Rubi B. In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol 2006;38:696-709
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 696-709
    • Maechler, P.1    Carobbio, S.2    Rubi, B.3
  • 3
    • 33751291197 scopus 로고    scopus 로고
    • Mitochondrial damages and the regulation of insulin secretion
    • Maechler P, de Andrade PB. Mitochondrial damages and the regulation of insulin secretion. Biochem Soc Trans 2006;34:824-827
    • (2006) Biochem Soc Trans , vol.34 , pp. 824-827
    • Maechler, P.1    De Andrade, P.B.2
  • 4
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-1812
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 6
    • 20244376316 scopus 로고    scopus 로고
    • Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
    • Anello M, Lupi R, Spampinato D, et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005;48:282-289
    • (2005) Diabetologia , vol.48 , pp. 282-289
    • Anello, M.1    Lupi, R.2    Spampinato, D.3
  • 7
    • 33746377553 scopus 로고    scopus 로고
    • Obesity-related derangements in metabolic regulation
    • Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Annu Rev Biochem 2006;75:367-401
    • (2006) Annu Rev Biochem , vol.75 , pp. 367-401
    • Muoio, D.M.1    Newgard, C.B.2
  • 8
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 2005;307:384-387
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 9
    • 0033762782 scopus 로고    scopus 로고
    • Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
    • Silva JP, Köhler M, Graff C, et al. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet 2000;26:336-340
    • (2000) Nat Genet , vol.26 , pp. 336-340
    • Silva, J.P.1    Köhler, M.2    Graff, C.3
  • 10
    • 0942276510 scopus 로고    scopus 로고
    • Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe
    • Colca JR, McDonald WG, Waldon DJ, et al. Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe. Am J Physiol Endocrinol Metab 2004;286:E252-E260
    • (2004) Am J Physiol Endocrinol Metab , vol.286 , pp. E252-E260
    • Colca, J.R.1    McDonald, W.G.2    Waldon, D.J.3
  • 11
    • 35448995690 scopus 로고    scopus 로고
    • MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone
    • Paddock ML, Wiley SE, Axelrod HL, et al. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A 2007;104:14342-14347
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14342-14347
    • Paddock, M.L.1    Wiley, S.E.2    Axelrod, H.L.3
  • 12
    • 34548254492 scopus 로고    scopus 로고
    • The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster
    • Wiley SE, Paddock ML, Abresch EC, et al. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem 2007;282:23745-23749
    • (2007) J Biol Chem , vol.282 , pp. 23745-23749
    • Wiley, S.E.1    Paddock, M.L.2    Abresch, E.C.3
  • 13
    • 34248359155 scopus 로고    scopus 로고
    • MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity
    • Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A 2007;104:5318-5323
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5318-5323
    • Wiley, S.E.1    Murphy, A.N.2    Ross, S.A.3    Van Der Geer, P.4    Dixon, J.E.5
  • 14
    • 35548990606 scopus 로고    scopus 로고
    • Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins
    • Lin J, Zhou T, Ye K, Wang J. Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. Proc Natl Acad Sci U S A 2007;104:14640-14645
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14640-14645
    • Lin, J.1    Zhou, T.2    Ye, K.3    Wang, J.4
  • 15
    • 84870302181 scopus 로고    scopus 로고
    • MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity
    • Kusminski CM, Holland WL, Sun K, et al. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med 2012;18:1539-1549
    • (2012) Nat Med , vol.18 , pp. 1539-1549
    • Kusminski, C.M.1    Holland, W.L.2    Sun, K.3
  • 16
    • 0032527121 scopus 로고    scopus 로고
    • Relative contribution of Ca2+-dependent mechanism in glucagon-induced glucose output from the liver
    • Yamatani K, Saito K, Ikezawa Y, et al. Relative contribution of Ca2+-dependent mechanism in glucagon-induced glucose output from the liver. Arch Biochem Biophys 1998;355:175-180
    • (1998) Arch Biochem Biophys , vol.355 , pp. 175-180
    • Yamatani, K.1    Saito, K.2    Ikezawa, Y.3
  • 17
    • 0015071923 scopus 로고
    • Role of glucagon and insulin in control of glucose turnover
    • Cherrington A, Vranic M. Role of glucagon and insulin in control of glucose turnover. Metabolism 1971;20:625-628
    • (1971) Metabolism , vol.20 , pp. 625-628
    • Cherrington, A.1    Vranic, M.2
  • 18
    • 34250854205 scopus 로고    scopus 로고
    • The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    • Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007;28:253-283
    • (2007) Endocr Rev , vol.28 , pp. 253-283
    • Dunning, B.E.1    Gerich, J.E.2
  • 19
    • 0023109225 scopus 로고
    • Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus
    • Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987;64:106-110
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 106-110
    • Reaven, G.M.1    Chen, Y.D.2    Golay, A.3    Swislocki, A.L.4    Jaspan, J.B.5
  • 20
    • 84855459920 scopus 로고    scopus 로고
    • Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
    • Unger RH, Cherrington AD. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest 2012;122:4-12
    • (2012) J Clin Invest , vol.122 , pp. 4-12
    • Unger, R.H.1    Cherrington, A.D.2
  • 21
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 2000;85:4053-4059
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 22
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu J, Woods J, Zhou YP, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 2006;55:1695-1704
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3
  • 23
    • 84924857231 scopus 로고    scopus 로고
    • Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration
    • Ye R, Holland WL, Gordillo R, et al. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. eLife 2014;3:3
    • (2014) ELife , vol.3 , pp. 3
    • Ye, R.1    Holland, W.L.2    Gordillo, R.3
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 70350351538 scopus 로고    scopus 로고
    • Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels
    • Li Z, Li Y, Chakraborty M, et al. Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels. J Biol Chem 2009;284:27010-27019
    • (2009) J Biol Chem , vol.284 , pp. 27010-27019
    • Li, Z.1    Li, Y.2    Chakraborty, M.3
  • 26
    • 0034101423 scopus 로고    scopus 로고
    • Analysis of the Cremediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas
    • Gannon M, Shiota C, Postic C, Wright CV, Magnuson M. Analysis of the Cremediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 2000;26:139-142
    • (2000) Genesis , vol.26 , pp. 139-142
    • Gannon, M.1    Shiota, C.2    Postic, C.3    Wright, C.V.4    Magnuson, M.5
  • 27
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986;261:11880-11889
    • (1986) J Biol Chem , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 29
    • 64149126546 scopus 로고    scopus 로고
    • Regulation of insulin secretion: A matter of phase control and amplitude modulation
    • Henquin JC. Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia 2009;52:739-751
    • (2009) Diabetologia , vol.52 , pp. 739-751
    • Henquin, J.C.1
  • 30
    • 0037317488 scopus 로고    scopus 로고
    • Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin
    • Combs TP, Berg AH, Rajala MW, et al. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003;52:268-276
    • (2003) Diabetes , vol.52 , pp. 268-276
    • Combs, T.P.1    Berg, A.H.2    Rajala, M.W.3
  • 31
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • Holland WL, Miller RA, Wang ZV, et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med 2011; 17:55-63
    • (2011) Nat Med , vol.17 , pp. 55-63
    • Holland, W.L.1    Miller, R.A.2    Wang, Z.V.3
  • 32
    • 77449154126 scopus 로고    scopus 로고
    • Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes
    • Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB. Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes 2010; 59:448-459
    • (2010) Diabetes , vol.59 , pp. 448-459
    • Lu, H.1    Koshkin, V.2    Allister, E.M.3    Gyulkhandanyan, A.V.4    Wheeler, M.B.5
  • 33
    • 0034707036 scopus 로고    scopus 로고
    • A ubiquitin-like system mediates protein lipidation
    • Ichimura Y, Kirisako T, Takao T, et al. A ubiquitin-like system mediates protein lipidation. Nature 2000;408:488-492
    • (2000) Nature , vol.408 , pp. 488-492
    • Ichimura, Y.1    Kirisako, T.2    Takao, T.3
  • 34
    • 47549092694 scopus 로고    scopus 로고
    • Atg8 controls phagophore expansion during autophagosome formation
    • Xie Z, Nair U, Klionsky DJ. Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell 2008;19:3290-3298
    • (2008) Mol Biol Cell , vol.19 , pp. 3290-3298
    • Xie, Z.1    Nair, U.2    Klionsky, D.J.3
  • 35
    • 0035856942 scopus 로고    scopus 로고
    • Mitochondrial function in normal and diabetic beta-cells
    • Maechler P, Wollheim CB. Mitochondrial function in normal and diabetic beta-cells. Nature 2001;414:807-812
    • (2001) Nature , vol.414 , pp. 807-812
    • Maechler, P.1    Wollheim, C.B.2
  • 36
    • 84860478719 scopus 로고    scopus 로고
    • Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets
    • Martino L, Masini M, Novelli M, et al. Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS One 2012;7: e36188
    • (2012) PLoS One , vol.7
    • Martino, L.1    Masini, M.2    Novelli, M.3
  • 37
    • 0344142468 scopus 로고    scopus 로고
    • Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    • Aita VM, Liang XH, Murty VV, et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999;59:59-65
    • (1999) Genomics , vol.59 , pp. 59-65
    • Aita, V.M.1    Liang, X.H.2    Murty, V.V.3
  • 38
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999;402:672-676
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 39
    • 84869147050 scopus 로고    scopus 로고
    • Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
    • Wang RC, Wei Y, An Z, et al. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012;338:956-959
    • (2012) Science , vol.338 , pp. 956-959
    • Wang, R.C.1    Wei, Y.2    An, Z.3
  • 40
    • 84902716930 scopus 로고    scopus 로고
    • Phosphorylated ubiquitin: A new shade of PINK1 in Parkin activation
    • Sauvé V, Gehring K. Phosphorylated ubiquitin: a new shade of PINK1 in Parkin activation. Cell Res 2014;24:1025-1026
    • (2014) Cell Res , vol.24 , pp. 1025-1026
    • Sauvé, V.1    Gehring, K.2
  • 41
    • 84879251778 scopus 로고    scopus 로고
    • Structure of Parkin reveals mechanisms for ubiquitin ligase activation
    • Trempe JF, Sauvé V, Grenier K, et al. Structure of Parkin reveals mechanisms for ubiquitin ligase activation. Science 2013;340:1451-1455
    • (2013) Science , vol.340 , pp. 1451-1455
    • Trempe, J.F.1    Sauvé, V.2    Grenier, K.3
  • 42
    • 84885817939 scopus 로고    scopus 로고
    • The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion
    • Jin HS, Kim J, Lee SJ, et al. The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion. Mol Cell Endocrinol 2014;382:178-189
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 178-189
    • Jin, H.S.1    Kim, J.2    Lee, S.J.3
  • 43
    • 84896824550 scopus 로고    scopus 로고
    • Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
    • Hoshino A, Ariyoshi M, Okawa Y, et al. Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes. Proc Natl Acad Sci U S A 2014;111:3116-3121
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 3116-3121
    • Hoshino, A.1    Ariyoshi, M.2    Okawa, Y.3
  • 44
    • 84857032953 scopus 로고    scopus 로고
    • Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin
    • Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012;22:320-333
    • (2012) Dev Cell , vol.22 , pp. 320-333
    • Lazarou, M.1    Jin, S.M.2    Kane, L.A.3    Youle, R.J.4
  • 45
    • 0038121031 scopus 로고    scopus 로고
    • The cellular protein level of Parkin is regulated by its ubiquitin-like domain
    • Finney N, Walther F, Mantel PY, Stauffer D, Rovelli G, Dev KK. The cellular protein level of Parkin is regulated by its ubiquitin-like domain. J Biol Chem 2003; 278:16054-16058
    • (2003) J Biol Chem , vol.278 , pp. 16054-16058
    • Finney, N.1    Walther, F.2    Mantel, P.Y.3    Stauffer, D.4    Rovelli, G.5    Dev, K.K.6
  • 46
    • 84922820920 scopus 로고    scopus 로고
    • Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment
    • Okatsu K, Kimura M, Oka T, Tanaka K, Matsuda N. Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment. J Cell Sci 2015;128:964-978
    • (2015) J Cell Sci , vol.128 , pp. 964-978
    • Okatsu, K.1    Kimura, M.2    Oka, T.3    Tanaka, K.4    Matsuda, N.5
  • 47
    • 84873045973 scopus 로고    scopus 로고
    • PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
    • Lazarou M, Narendra DP, Jin SM, Tekle E, Banerjee S, Youle RJ. PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. J Cell Biol 2013;200:163-172
    • (2013) J Cell Biol , vol.200 , pp. 163-172
    • Lazarou, M.1    Narendra, D.P.2    Jin, S.M.3    Tekle, E.4    Banerjee, S.5    Youle, R.J.6
  • 48
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saltiel AR, Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 1996;45:1661-1669
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 49
    • 78650866390 scopus 로고    scopus 로고
    • Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice
    • Kawashima S, Matsuoka TA, Kaneto H, et al. Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice. Biochem Biophys Res Commun 2011;404:534-540
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 534-540
    • Kawashima, S.1    Matsuoka, T.A.2    Kaneto, H.3
  • 50
    • 12144290529 scopus 로고    scopus 로고
    • Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress
    • Ishida H, Takizawa M, Ozawa S, et al. Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: possible protection of beta cells from oxidative stress. Metabolism 2004;53:488-494
    • (2004) Metabolism , vol.53 , pp. 488-494
    • Ishida, H.1    Takizawa, M.2    Ozawa, S.3
  • 51
    • 50949114536 scopus 로고    scopus 로고
    • PANIC-ATTAC: A mouse model for inducible and reversible beta-cell ablation
    • Wang ZV, Mu J, Schraw TD, et al. PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes 2008;57:2137-2148
    • (2008) Diabetes , vol.57 , pp. 2137-2148
    • Wang, Z.V.1    Mu, J.2    Schraw, T.D.3
  • 52
    • 33644635560 scopus 로고    scopus 로고
    • In vitro and in vivo improvement of islet survival following treatment with nerve growth factor
    • Miao G, Mace J, Kirby M, et al. In vitro and in vivo improvement of islet survival following treatment with nerve growth factor. Transplantation 2006;81:519-524
    • (2006) Transplantation , vol.81 , pp. 519-524
    • Miao, G.1    Mace, J.2    Kirby, M.3
  • 53
    • 0034771405 scopus 로고    scopus 로고
    • NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro
    • Pierucci D, Cicconi S, Bonini P, et al. NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro. Diabetologia 2001;44:1281-1295
    • (2001) Diabetologia , vol.44 , pp. 1281-1295
    • Pierucci, D.1    Cicconi, S.2    Bonini, P.3
  • 54
    • 84871690380 scopus 로고    scopus 로고
    • Trefoil factor 2 promotes cell proliferation in pancreatic β-cells through CXCR-4-mediated ERK1/2 phosphorylation
    • Orime K, Shirakawa J, Togashi Y, et al. Trefoil factor 2 promotes cell proliferation in pancreatic β-cells through CXCR-4-mediated ERK1/2 phosphorylation. Endocrinology 2013;154:54-64
    • (2013) Endocrinology , vol.154 , pp. 54-64
    • Orime, K.1    Shirakawa, J.2    Togashi, Y.3
  • 55
    • 84857785686 scopus 로고    scopus 로고
    • Mitochondrial signals drive insulin secretion in the pancreatic β-cell
    • Wiederkehr A, Wollheim CB. Mitochondrial signals drive insulin secretion in the pancreatic β-cell. Mol Cell Endocrinol 2012;353:128-137
    • (2012) Mol Cell Endocrinol , vol.353 , pp. 128-137
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 56
    • 77954859197 scopus 로고    scopus 로고
    • The role of mitochondria in the pathogenesis of type 2 diabetes
    • Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev 2010;31:364-395
    • (2010) Endocr Rev , vol.31 , pp. 364-395
    • Patti, M.E.1    Corvera, S.2
  • 58
    • 0025109848 scopus 로고
    • Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans
    • Ohta M, Nelson D, Nelson J, Meglasson MD, Erecinska M. Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. J Biol Chem 1990;265:17525-17532
    • (1990) J Biol Chem , vol.265 , pp. 17525-17532
    • Ohta, M.1    Nelson, D.2    Nelson, J.3    Meglasson, M.D.4    Erecinska, M.5
  • 59
    • 0031892856 scopus 로고    scopus 로고
    • Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells
    • Kennedy ED, Maechler P, Wollheim CB. Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes 1998; 47:374-380
    • (1998) Diabetes , vol.47 , pp. 374-380
    • Kennedy, E.D.1    Maechler, P.2    Wollheim, C.B.3
  • 60
    • 84921458749 scopus 로고    scopus 로고
    • Role of islet β cell autophagy in the pathogenesis of diabetes
    • Lee MS. Role of islet β cell autophagy in the pathogenesis of diabetes. Trends Endocrinol Metab 2014;25:620-627
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 620-627
    • Lee, M.S.1
  • 61
    • 75949130828 scopus 로고    scopus 로고
    • PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    • Geisler S, Holmström KM, Skujat D, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010;12:119-131
    • (2010) Nat Cell Biol , vol.12 , pp. 119-131
    • Geisler, S.1    Holmström, K.M.2    Skujat, D.3
  • 63
    • 46949109487 scopus 로고    scopus 로고
    • Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
    • Leak TS, Mychaleckyj JC, Smith SG, et al. Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. Hum Genet 2008;124:63-71
    • (2008) Hum Genet , vol.124 , pp. 63-71
    • Leak, T.S.1    Mychaleckyj, J.C.2    Smith, S.G.3
  • 64
    • 75949098487 scopus 로고    scopus 로고
    • PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    • Vives-Bauza C, Zhou C, Huang Y, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A 2010;107:378-383
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 378-383
    • Vives-Bauza, C.1    Zhou, C.2    Huang, Y.3
  • 65
    • 75949104449 scopus 로고    scopus 로고
    • Mitochondria get a Parkin' ticket
    • Wild P, Dikic I. Mitochondria get a Parkin' ticket. Nat Cell Biol 2010;12:104-106
    • (2010) Nat Cell Biol , vol.12 , pp. 104-106
    • Wild, P.1    Dikic, I.2
  • 66
    • 77958014883 scopus 로고    scopus 로고
    • Paracrinology of islets and the paracrinopathy of diabetes
    • Unger RH, Orci L. Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci U S A 2010;107:16009-16012
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16009-16012
    • Unger, R.H.1    Orci, L.2
  • 67
    • 77954980506 scopus 로고    scopus 로고
    • Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice
    • Hancock AS, Du A, Liu J, Miller M, May CL. Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice. Mol Endocrinol 2010;24:1605-1614
    • (2010) Mol Endocrinol , vol.24 , pp. 1605-1614
    • Hancock, A.S.1    Du, A.2    Liu, J.3    Miller, M.4    May, C.L.5
  • 68
    • 79551600048 scopus 로고    scopus 로고
    • Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
    • Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 2011;60: 391-397
    • (2011) Diabetes , vol.60 , pp. 391-397
    • Lee, Y.1    Wang, M.Y.2    Du, X.Q.3    Charron, M.J.4    Unger, R.H.5
  • 69
    • 84868628920 scopus 로고    scopus 로고
    • The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis
    • Gezginci-Oktayoglu S, Karatug A, Bolkent S. The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis. Diabetes Metab Res Rev 2012;28:654-662
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 654-662
    • Gezginci-Oktayoglu, S.1    Karatug, A.2    Bolkent, S.3
  • 70
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel F, Népote V, Avril I, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010;464:1149-1154
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Népote, V.2    Avril, I.3


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