Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels

Journal of Biological Chemistry

Volumn 284, Issue 39, 2009, Pages 27010-27019

  Li, Zhiqiang ^a   Li, Yan ^a   Chakraborty, Mahua ^a   Fan, Yifan ^a   Bui, Hai H ^b   Peake, David A ^b   Kuo, Ming Shang ^b   Xiao, Xiao ^c   Cao, Guoqing ^b   Jiang, Xian Cheng ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CELL LYSIS; CHOLESTEROL EFFLUX; HEPATOCYTES; HIGH DENSITY LIPOPROTEIN; KEY ENZYMES; KNOCK OUTS; LIPOPROTEIN METABOLISM; PHOSPHATIDYLCHOLINE; PLASMA LIPOPROTEINS; PLASMA MEMBRANES; SERINE PALMITOYLTRANSFERASES; SPHINGOMYELIN; WILD TYPES;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CELL MEMBRANES; METABOLISM; PHYSIOLOGY; PLASMAS;

LIVER;

APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE; SERINE PALMITOYLTRANSFERASE; SERINE PALMITOYLTRANSFERASE SUBUNIT 2; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL MEMBRANE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOLYSIS; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEFICIENCY; FEMALE; KNOCKOUT MOUSE; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; LIVER CELL; LIVER LEVEL; LIVER PARENCHYMA; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; APOLIPOPROTEINS E; BLOTTING, WESTERN; CELL MEMBRANE; CELLS, CULTURED; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIPIDS; LIPOPROTEINS; LIVER; MACROPHAGES; MASS SPECTROMETRY; MICE; MICE, KNOCKOUT; SERINE C-PALMITOYLTRANSFERASE; SPHINGOMYELINS;

MUS;

EID: 70350351538     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.042028     Document Type: Article

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