Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit

Biochemistry

Volumn 55, Issue 18, 2016, Pages 2646-2660

  Fudo, Satoshi ^a   Yamamoto, Norio ^b,c   Nukaga, Michiyoshi ^d   Odagiri, Takato ^c   Tashiro, Masato ^c   Hoshino, Tyuji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d JOSAI INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL AGENTS; BINDING ENERGY; BINDING SITES; BINS; METAL IONS; METALS; MOLECULAR DYNAMICS; PROTEINS; VIRUSES;

ANALYSIS OF SIMULATIONS; CRYSTAL STRUCTURE ANALYSIS; ENDONUCLEASE ACTIVITIES; ENDONUCLEASE INHIBITORS; MOLECULAR DYNAMICS SIMULATIONS; MULTIPLE BINDING SITES; PROTEIN CRYSTALLIZATION; SIMULATION STRUCTURE;

CRYSTAL STRUCTURE;

ANTIVIRUS AGENT; ENDONUCLEASE INHIBITOR; ESTERASE INHIBITOR; METAL ION; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PROTEIN BINDING; VIRAL PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIELECTRIC CONSTANT; DRUG CONFORMATION; ENZYME ACTIVITY; INFLUENZA A VIRUS (H1N1); INFLUENZA VIRUS; METAL BINDING; MOLECULAR DYNAMICS; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTON TRANSPORT; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; PROTEIN DOMAIN;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN DOMAINS; VIRAL PROTEINS;

EID: 84969582328     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b01087     Document Type: Article

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