Atopic dermatitis and filaggrin

Current Opinion in Immunology

Volumn 42, Issue , 2016, Pages 1-8

  Cabanillas, Beatriz ^a   Novak, Natalija ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FILAGGRIN; INTERLEUKIN 25; INTERLEUKIN 33; THYMIC STROMAL LYMPHOPOIETIN; INTERMEDIATE FILAMENT PROTEIN;

ATOPIC DERMATITIS; FILAGGRIN DEFICIENCY; FLG GENE; GENE; GENE MUTATION; HEREDITY; HUMAN; IMMUNOMODULATION; NONHUMAN; PATHOGENESIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SKIN PROTECTION; STRATUM CORNEUM; ANIMAL; CHILD; DISEASE MODEL; ECZEMA; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE; MUTATION; PATHOLOGY; SKIN;

ANIMALS; CHILD; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; ECZEMA; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MICE; MOLECULAR TARGETED THERAPY; MUTATION; SKIN;

EID: 84969530921     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2016.05.002     Document Type: Review

References (39)

1. Thyssen J.P., Kezic S. Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 2014, 134:792-799.
2. Weidinger S., Novak N. Atopic dermatitis. Lancet 2016, 387:1109-1122.
3. Irvine A.D., McLean W.H., Leung D.Y. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011, 365:1315-1327.
4. Thawer-Esmail F., Jakasa I., Todd G., Wen Y., Brown S.J., Kroboth K., Campbell L.E., O'Regan G.M., McLean W.H., Irvine A.D., et al. South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin. J Allergy Clin Immunol 2014, 133:280-282.
5. Margolis D.J., Gupta J., Apter A.J., Hoffstad O., Papadopoulos M., Rebbeck T.R., Wubbenhorst B., Mitra N. Exome sequencing of filaggrin and related genes in African-American children with atopic dermatitis. J Invest Dermatol 2014, 134:2272-2274.
6. Margolis D.J., Gupta J., Apter A.J., Ganguly T., Hoffstad O., Papadopoulos M., Rebbeck T.R., Mitra N. Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects. J Allergy Clin Immunol 2014, 133:784-789.
7. Esparza-Gordillo J., Matanovic A., Marenholz I., Bauerfeind A., Rohde K., Nemat K., Lee-Kirsch M.A., Nordenskjöld M., Winge M.C., Keil T., et al. Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance. PLoS Genet 2015, 11:e1005076.
8. Seltmann J., Roesner L.M., von Hesler F.W., Wittmann M., Werfel T. IL-33 impacts on the skin barrier by downregulating the expression of filaggrin. J Allergy Clin Immunol 2015, 135:1659-1661.
9. Kim B.E., Bin L., Ye Y.M., Ramamoorthy P., Leung D.Y. IL-25 enhances HSV-1 replication by inhibiting filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication. J Invest Dermatol 2013, 133:2678-2685.
10. Kim J.H., Bae H.C., Ko N.Y., Lee S.H., Jeong S.H., Lee H., Ryu W.I., Kye Y.C., Son S.W. Thymic stromal lymphopoietin downregulates filaggrin expression by signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase (ERK) phosphorylation in keratinocytes. J Allergy Clin Immunol 2015, 136:205-208.
11. Margolis D.J., Kim B., Apter A.J., Gupta J., Hoffstad O., Papadopoulos M., Mitra N. Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis. JAMA Dermatol 2014, 150:254-259.
12. Pellerin L., Henry J., Hsu C.Y., Balica S., Jean-Decoster C., Méchin M.C., Hansmann B., Rodriguez E., Weindinger S., Schmitt A.M., et al. Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin. J Allergy Clin Immunol 2013, 131:1094-1102.
13. Pendaries V., Malaisse J., Pellerin L., Le Lamer M., Nachat R., Kezic S., Schmitt A.M., Paul C., Poumay Y., Serre G., Simon M. Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiation. J Invest Dermatol 2014, 134:2938-2946.
14. Hönzke S., Wallmeyer L., Ostrowski A., Radbruch M., Mundhenk L., Schäfer-Korting M., Hedtrich S. Influence of Th2 cytokines on the cornified envelope, tight junction proteins, and β-defensins in filaggrin-deficient skin equivalents. J Invest Dermatol 2016, 136:631-639.
15. Vávrová K., Henkes D., Strüver K., Sochorová M., Skolová B., Witting M.Y., Friess W., Schreml S., Meier R.J., Schäfer-Korting M., et al. Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct. J Invest Dermatol 2014, 134:746-753.
16. Jarrett R., Salio M., Lloyd-Lavery A., Subramaniam S., Bourgeois E., Archer C., Cheung K.L., Hardman C., Chandler D., Salimi M., et al. Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase. Sci Transl Med 2016, 8:325.
17. Leitch C.S., Natafji E., Yu C., Abdul-Ghaffar S., Madarasingha N., Venables Z.C., Chu R., Fitch P.M., Muinonen-Martin A.J., Campbell L.E., et al. Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. J Allergy Clin Immunol 2016, 10.1016/j.jaci.2015.11.040.
18. Riethmuller C., McAleer M.A., Koppes S.A., Abdayem R., Franz J., Haftek M., Campbell L.E., MacCallum S.F., McLean W.H., Irvine A.D., Kezic S. Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis. J Allergy Clin Immunol 2015, 136:1573-1580.
19. Cole C., Kroboth K., Schurch N.J., Sandilands A., Sherstnev A., O'Regan G.M., Watson R.M., McLean W.H., Barton G.J., Irvine A.D., Brown S.J. Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis. J Allergy Clin Immunol 2014, 134:82-91.
20. Flohr C., England K., Radulovic S., McLean W.H., Campbel L.E., Barker J., Perkin M., Lack G. Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br J Dermatol 2010, 163:1333-1336.
21. Kelleher M., Dunn-Galvin A., Hourihane J.O., Murray D., Campbell L.E., McLean W.H., Irvine A.D. Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. J Allergy Clin Immunol 2015, 135:930-935.
22. Oyoshi M.K., Beaupré J., Venturelli N., Lewis C.N., Iwakura Y., Geha R.S. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J Allergy Clin Immunol 2015, 135:1511-1518.
23. Drongelen V., Haisma E.M., Out-Luiting J.J., Nibbering P.H., El Ghalbzouri A. Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models. Clin Exp Allergy 2014, 44:1515-1524.
24. Brauweiler A.M., Bin L., Kim B.E., Oyoshi M.K., Geha R.S., Goleva E., Leung D.Y. Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death. J Allergy Clin Immunol 2013, 131:421-427.
25. Garrett J.P., Hoffstad O., Apter A.J., Margolis D.J. Racial comparison of filaggrin null mutations in asthmatic patients with atopic dermatitis in a US population. J Allergy Clin Immunol 2013, 132:1232-1234.
26. Brown S.J., Asai Y., Cordell H.J., Campbell L.E., Zhao Y., Liao H., Northstone K., Henderson J., Alizadehfar R., Ben-Shoshan M., et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol 2011, 127:661-667.
27. Tan H.T., Ellis J.A., Koplin J.J., Matheson M.C., Gurrin L.C., Lowe A.J., Martin P.E., Dang T.D., Wake M., Tang M.L., et al. Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants. J Allergy Clin Immunol 2012, 130:1211-1213.
28. Brough H.A., Simpson A., Makinson K., Hankinson J., Brown S., Douiri A., Belgrave D.C., Penagos M., Stephens A.C., McLean W.H., et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol 2014, 134:867-875.
29. Kelleher M.M., Dunn-Galvin A., Gray C., Murray D.M., Kiely M., Kenny L., McLean W.H., Irvine A.D., Hourihane J.O. Skin barrier impairment at birth predicts food allergy at 2 years of age. J Allergy Clin Immunol 2016, 137:1111-1116.
30. Thyssen J.P., Tang L., Husemoen L.L., Stender S., Szecsi P.B., Menné T., Johansen J.D., Linneberg A. Filaggrin gene mutations are not associated with food and aeroallergen sensitization without concomitant atopic dermatitis in adults. J Allergy Clin Immunol 2015, 135:1375-1378.
31. Saunders S.P., Goh C.S., Brown S.J., Palmer C.N., Porter R.M., Cole C., Campbell L.E., Gierlinski M., Barton G.J., Schneider G., et al. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol 2013, 132:1121-1129.
32. Sasaki T., Shiohama A., Kubo A., Kawasaki H., Ishida-Yamamoto A., Yamada T., Hachiya T., Shimizu A., Okano H., Kudoh J., Amagai M. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol 2013, 132:1111-1120.
33. Saunders S.P., Moran T., Floudas A., Wurlod F., Kaszlikowska A., Salimi M., Quinn E.M., Oliphant C.J., Núñez G., McManus R., et al. Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J Allergy Clin Immunol 2016, 137:482-491.
34. Otsuka A., Doi H., Egawa G., Maekawa A., Fujita T., Nakamizo S., Nakashima C., Nakajima S., Watanabe T., Miyachi Y., et al. Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression. J Allergy Clin Immunol 2014, 133:139-146.
35. Stout T.E., McFarland T., Mitchell J.C., Appukuttan B., Stout J.T. Recombinant filaggrin is internalized and processed to correct filaggrin deficiency. J Invest Dermatol 2014, 134:423-429.
36. Amano W., Nakajima S., Kunugi H., Numata Y., Kitoh A., Egawa G., Dainichi T., Honda T., Otsuka A., Kimoto Y., et al. The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling. J Allergy Clin Immunol 2015, 136:667-677.
37. van den Bogaard E.H., Bergboer J.G., Vonk-Bergers M., van Vlijmen-Willems I.M., Hato S.V., van der Valk P.G., Schröder J.M., Joosten I., Zeeuwen P.L., Schalkwijk J. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest 2013, 123:917-927.
38. Ming M., Zhao B., Shea C.R., Shah P., Qiang L., White S.R., Sims D.M., He Y.Y. Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge. J Allergy Clin Immunol 2015, 135:936-945.
39. McAleer M.A., Irvine A.D. The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol 2013, 131:280-291.