Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 1, 2014, Pages 82-91

  Cole, Christian ^a   Kroboth, Karin ^a   Schurch, Nicholas J ^a   Sandilands, Aileen ^a   Sherstnev, Alexander ^a   O'Regan, Grainne M ^b   Watson, Rosemarie M ^b   Irwin McLean, W H ^a   Barton, Geoffrey J ^a   Irvine, Alan D ^b,c   Brown, Sara J ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Atopic dermatitis; direct RNA sequencing; eczema; filaggrin; gene expression; single molecule; skin; tissue; transcriptome

Indexed keywords

FILAGGRIN; INTERFERON; TRANSCRIPTOME; INTERMEDIATE FILAMENT PROTEIN;

ADOLESCENT; ARTICLE; ATOPIC DERMATITIS; CELLULAR STRESS RESPONSE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ECZEMA; EXTRACELLULAR SPACE; FEMALE; GENE EXPRESSION; GENE ONTOLOGY; GENOTYPE; HAPLOINSUFFICIENCY; HUMAN; HUMAN TISSUE; LIPID METABOLISM; LOSS OF FUNCTION MUTATION; MALE; MOLECULAR PATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; SKIN BIOPSY; TRANSCRIPTOMICS; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; METABOLISM; PATHOLOGY; SKIN; YOUNG ADULT;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; DERMATITIS, ATOPIC; EXTRACELLULAR SPACE; FEMALE; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INTERMEDIATE FILAMENT PROTEINS; LIPID METABOLISM; MALE; SKIN; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84903731426     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.04.021     Document Type: Article

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