A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 5, 2013, Pages

  Sasaki, Takashi ^a   Shiohama, Aiko ^a   Kubo, Akiharu ^a   Kawasaki, Hiroshi ^a   Ishida Yamamoto, Akemi ^b   Yamada, Taketo ^a   Hachiya, Takayuki ^c   Shimizu, Atsushi ^a   Okano, Hideyuki ^a   Kudoh, Jun ^a   Amagai, Masayuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c Medical & Biological Laboratories Co Ltd   (Japan)

Author keywords

Atopic dermatitis; filaggrin; skin barrier; stratum corneum; trans Golgi network

Indexed keywords

MEMBRANE PROTEIN; PROTEIN TMEM79; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DNA SEQUENCE; ECZEMA; FILAGGRIN GENE; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; MISSENSE MUTATION; MOUSE; NONHUMAN; NONSENSE MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; STRATUM CORNEUM; TMEM79 GENE; TRANS GOLGI NETWORK; TRANSGENE;

EID: 84887025956     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.08.027     Document Type: Article

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