The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 3, 2015, Pages 667-677.e7

  Amano, Wataru ^a,b   Nakajima, Saeko ^a   Kunugi, Hayato ^b   Numata, Yasuharu ^b   Kitoh, Akihiko ^a   Egawa, Gyohei ^a   Dainichi, Teruki ^a   Honda, Tetsuya ^a   Otsuka, Atsushi ^a   Kimoto, Yukari ^b   Yamamoto, Yasuo ^b   Tanimoto, Atsuo ^b   Matsushita, Mutsuyoshi ^b   Miyachi, Yoshiki ^a   Kabashima, Kenji ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN TOBACCO INC   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Atopic dermatitis; filaggrin; Janus kinase inhibitor; keratinocyte differentiation; signal transducer and activator of transcription 3

Indexed keywords

FILAGGRIN; INTERLEUKIN 13; INTERLEUKIN 4; JANUS KINASE INHIBITOR; JTE 052; SMALL INTERFERING RNA; STAT3 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG; INTERMEDIATE FILAMENT PROTEIN; PROTEIN KINASE INHIBITOR; STAT3 PROTEIN, MOUSE; STAT6 PROTEIN, MOUSE;

ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG TARGETING; DRY SKIN; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN PERMEABILITY; TH2 CELL; TOPICAL TREATMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTIFICIAL SKIN; C57BL MOUSE; DERMATITIS, ATOPIC; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOCOMPROMIZED PATIENT; IMMUNOLOGY; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; XENOGRAFT;

ANIMALS; CELL DIFFERENTIATION; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; IMMUNOCOMPROMISED HOST; INTERLEUKIN-13; INTERLEUKIN-4; INTERMEDIATE FILAMENT PROTEINS; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, NUDE; PROTEIN KINASE INHIBITORS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; SKIN, ARTIFICIAL; STAT3 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANSPLANTATION, HETEROLOGOUS;

EID: 84941172400     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.03.051     Document Type: Article

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