Filaggrin gene mutations are not associated with food and aeroallergen sensitization without concomitant atopic dermatitis in adults

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 5, 2015, Pages 1375-1378.e1

  Thyssen, Jacob P ^a   Tang, Line ^b   Husemoen, Lise Lotte N ^b   Stender, Steen ^a   Szecsi, Pal B ^a   Menné, Torkil ^a   Johansen, Jeanne D ^a   Linneberg, Allan ^b,c,d  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b Unit for Psychotherapy Education and Research   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FILAGGRIN; FOOD ALLERGEN; IMMUNOGLOBULIN E; PROFILIN; INTERMEDIATE FILAMENT PROTEIN;

ADULT DISEASE; ALLELE; ARTEMISIA VULGARIS; ATOPIC DERMATITIS; CAT; DERMATOPHAGOIDES PTERONYSSINUS; DOG; EGG ALLERGY; FOLLOW UP; GENE MUTATION; HORSE; HUMAN; LETTER; MILK ALLERGY; MOULD; PEANUT ALLERGY; PHLEUM PRATENSE; PRIORITY JOURNAL; WHEAT ALLERGY; ADULT; COMPLICATION; FOOD ALLERGY; GENETIC ASSOCIATION; GENETICS; HYPERSENSITIVITY; MUTATION;

ADULT; DERMATITIS, ATOPIC; FOOD HYPERSENSITIVITY; GENETIC ASSOCIATION STUDIES; HUMANS; HYPERSENSITIVITY; INTERMEDIATE FILAMENT PROTEINS; MUTATION;

EID: 84937512304     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.001     Document Type: Article

References (9)

1. J.P. Thyssen, and S. Kezic Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis J Allergy Clin Immunol 134 2014 792 799
2. P.G. Fallon, T. Sasaki, A. Sandilands, L.E. Campbell, S.P. Saunders, N.E. Mangan, and et al. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming Nat Genet 41 2009 602 608
3. A.D. Irvine, W.H. McLean, and D.Y. Leung Filaggrin mutations associated with skin and allergic diseases N Engl J Med 365 2011 1315 1327
4. H.A. Brough, A. Simpson, K. Makinson, J. Hankinson, S. Brown, A. Douiri, and et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations J Allergy Clin Immunol 134 2014 867 875
5. S.J. Brown, Y. Asai, H.J. Cordell, L.E. Campbell, Y. Zhao, H. Liao, and et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy J Allergy Clin Immunol 127 2011 661 667
6. H.T. Tan, J.A. Ellis, J.J. Koplin, M.C. Matheson, L.C. Gurrin, A.J. Lowe, and et al. Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants J Allergy Clin Immunol 130 2012 1211 1213
7. D. Venkataraman, N. Soto-Ramirez, R.J. Kurukulaaratchy, J.W. Holloway, W. Karmaus, S.L. Ewart, and et al. Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence J Allergy Clin Immunol 134 2014 876 882.e4
8. C. Flohr, M. Perkin, K. Logan, T. Marrs, S. Radulovic, L.E. Campbell, and et al. Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants J Invest Dermatol 134 2014 345 350
9. M. Meldgaard, P.B. Szecsi, B.C. Carlsen, J.P. Thyssen, J.D. Johansen, T. Menne, and et al. A novel multiplex analysis of filaggrin polymorphisms: a universally applicable method for genotyping Clin Chim Acta 413 2012 1488 1492