Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 5, 2012, Pages 1211-1213.e3

  Tan, Hern Tze Tina ^a,b   Ellis, Justine A ^a,b   Koplin, Jennifer J ^a   Matheson, Melanie C ^b   Gurrin, Lyle C ^a,b   Lowe, Adrian J ^a,b   Martin, Pamela E ^a,b   Dang, Thanh D ^a,b   Wake, Melissa ^a,b   Tang, Mimi L K ^a,b   Ponsonby, Anne Louise ^a,b   Dharmage, Shyamali C ^a,b   Allen, Katrina J ^a,b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FILAGGRIN; IMMUNOGLOBULIN E;

DNA DETERMINATION; ECZEMA; EGG ALLERGY; FLG GENE; FOOD ALLERGY; FOOD SENSITIZATION; GENE; GENE MUTATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INFANT; LETTER; PEANUT ALLERGY; PRICK TEST; PRIORITY JOURNAL; SENSITIZATION; SESAME;

EID: 84869118732     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.07.022     Document Type: Article

References (7)

1. A.D. Irvine, W.H. McLean, and D.Y. Leung Filaggrin mutations associated with skin and allergic diseases N Engl J Med 365 2011 1315 1327
2. S.J. Brown, Y. Asai, H.J. Cordell, L.E. Campbell, Y. Zhao, and H. Liao Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy J Allergy Clin Immunol 127 2011 661 667
3. N.J. Osborne, J.J. Koplin, P.E. Martin, L.C. Gurrin, L. Thiele, and M.L. Tang The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability Clin Exp Allergy 40 2010 1516 1522
4. R. Sporik, D.J. Hill, and C.S. Hosking Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children Clin Exp Allergy 30 2000 1541 1546
5. J.J. Koplin, M.L. Tang, P.E. Martin, N.J. Osborne, A.J. Lowe, and A.L. Ponsonby Predetermined challenge eligibility and cessation criteria for oral food challenges in the HealthNuts population-based study of infants J Allergy Clin Immunol 129 2012 1145 1147
6. C. Flohr, K. England, S. Radulovic, W.H. McLean, L.E. Campbel, and J. Barker Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age Br J Dermatol 163 2010 1333 1336
7. G. Lack, D. Fox, K. Northstone, and J. Golding Avon Longitudinal Study of Parents and Children Study Team. Factors associated with the development of peanut allergy in childhood N Engl J Med 348 2003 977 985 (Pubitemid 36302242)