Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 2, 2013, Pages

  Brauweiler, Anne M ^a   Bin, Lianghua ^a   Kim, Byung Eui ^a   Oyoshi, Michiko K ^b   Geha, Raif S ^b   Goleva, Elena ^a   Leung, Donald Y M ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

acid sphingomyelinase; Atopic dermatitis; filaggrin; skin barrier; Staphylococcus aureus; toxin

Indexed keywords

CYTOKERATIN 5; FILAGGRIN; LACTATE DEHYDROGENASE; RNA; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; STAPHYLOCOCCUS ALPHA TOXIN;

ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; BACTERIAL VIRULENCE; BINDING SITE; CELL DEATH; CELL DIFFERENTIATION; CELL PROTECTION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE EXACERBATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME RELEASE; GENE EXPRESSION; GENE SILENCING; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SKIN BIOPSY; STAPHYLOCOCCUS AUREUS;

EID: 84873414448     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.10.030     Document Type: Article

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