A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Journal of Experimental Medicine

Volumn 213, Issue 5, 2016, Pages 771-790

  Schmidt, Florian I ^a   Lu, Alvin ^b,c   Chen, Jeff W ^a   Ruan, Jianbin ^b,c   Tang, Catherine ^b,c   Wu, Hao ^b,c   Ploegh, Hidde L ^a,d  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AIM2 PROTEIN; ASC PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NANOBODY; NEURONAL APOPTOSIS INHIBITORY PROTEIN; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; NAIP PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ALPACA; ARTICLE; COMPLEMENTARITY DETERMINING REGION; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; CYTOKINE RELEASE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PYROPTOSIS; SIZE EXCLUSION CHROMATOGRAPHY; A-549 CELL LINE; FEMALE; IMMUNOLOGY; MALE; MONOCYTE;

A549 CELLS; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; FEMALE; HUMANS; INFLAMMASOMES; MALE; MONOCYTES; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; SINGLE-CHAIN ANTIBODIES;

EID: 84969261036     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151790     Document Type: Article

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