The Techno-Economic Basis for Coproduct Manufacturing to Enable Hydrocarbon Fuel Production from Lignocellulosic Biomass

ACS Sustainable Chemistry and Engineering

Volumn 4, Issue 6, 2016, Pages 3196-3211

  Biddy, Mary J ^a   Davis, Ryan ^a   Humbird, David ^a   Tao, Ling ^a   Dowe, Nancy ^a   Guarnieri, Michael T ^a   Linger, Jeffrey G ^a   Karp, Eric M ^a   Salvachúa, Davinia ^a   Vardon, Derek R ^a   Beckham, Gregg T ^a  

^a NATIONAL RENEWABLE ENERGY LABORATORY   (United States)

Author keywords

Biochemicals; Biofuels; Biorefinery; Integration; Lignocellulose

Indexed keywords

BENCHMARKING; BIOCONVERSION; BIOFUELS; BIOMASS; CELLULOSE; COSTS; ECONOMIC ANALYSIS; ENZYMATIC HYDROLYSIS; FUEL PURIFICATION; FUELS; HYDROCARBON REFINING; HYDROCARBONS; INDUSTRIAL RESEARCH; INTEGRATION; RISK ASSESSMENT; SUGARS;

BIOCHEMICALS; BIOREFINERIES; CATALYTIC HYDROTREATING; LIGNOCELLULOSE; LIGNOCELLULOSIC BIOMASS; RECOVERY AND PURIFICATIONS; TECHNO- ECONOMIC ANALYSIS; TWO-STEP PRETREATMENT;

COST BENEFIT ANALYSIS;

EID: 84968648928     PISSN: None     EISSN: 21680485     Source Type: Journal    
DOI: 10.1021/acssuschemeng.6b00243     Document Type: Article

References (122)

1. Pacala, S.; Socolow, R. Stabilization Wedges: Solving the Climate Problem for the Next 50 Years with Current Technologies Science 2004, 305 (5686) 968-972 10.1126/science.1100103
2. Ragauskas, A.; Williams, C.; Davison, B.; Britovsek, G.; Cairney, J.; Eckert, C.; Frederick, W.; Hallett, J.; Leak, D.; Liotta, C.; Mielenz, J.; Murphy, R.; Templer, R.; Tschaplinski, T. The Path Forward for Biofuels and Biomaterials Science 2006, 311, 484-489 10.1126/science.1114736
3. Souza, G. M.; Victoria, R. L.; Joly, C. A.; Verdade, L. M. Bioenergy & Sustainability: Bridging the Gaps; Scientific Committee on Problems of the Environment (SCOPE), 2015.
4. Lane, J. Biofuels Mandates around the World; Biofuels Digest, December 31, 2014.
5. Tilman, D.; Socolow, R.; Foley, J. A.; Hill, J.; Larson, E.; Lynd, L.; Pacala, S.; Reilly, J.; Searchinger, T.; Somerville, C.; Williams, R. Beneficial Biofuels-the Food, Energy, and Environment Trilemma Science 2009, 325 (5938) 270 10.1126/science.1177970
6. Himmel, M. E.; Ding, S.-Y.; Johnson, D. K.; Adney, W. S.; Nimlos, M. R.; Brady, J. W.; Foust, T. D. Biomass Recalcitrance: Engineering Plants and Enzymes for Biofuels Production Science 2007, 315 (5813) 804-807 10.1126/science.1137016
7. Chundawat, S. P. S.; Beckham, G. T.; Himmel, M. E.; Dale, B. E. Deconstruction of Lignocellulosic Biomass to Fuels and Chemicals Annu. Rev. Chem. Biomol. Eng. 2011, 2, 121-145 10.1146/annurev-chembioeng-061010-114205
8. Wyman, C. E.; Dale, B. E.; Elander, R. T.; Holtzapple, M.; Ladisch, M. R.; Lee, Y. Coordinated Development of Leading Biomass Pretreatment Technologies Bioresour. Technol. 2005, 96 (18) 1959-1966 10.1016/j.biortech.2005.01.010
9. Mosier, N.; Wyman, C.; Dale, B.; Elander, R.; Lee, Y.; Holtzapple, M.; Ladisch, M. Features of Promising Technologies for Pretreatment of Lignocellulosic Biomass Bioresour. Technol. 2005, 96 (6) 673-686 10.1016/j.biortech.2004.06.025
10. Lynd, L. R.; Van Zyl, W. H.; McBride, J. E.; Laser, M. Consolidated Bioprocessing of Cellulosic Biomass: An Update Curr. Opin. Biotechnol. 2005, 16 (5) 577-583 10.1016/j.copbio.2005.08.009
11. Öhgren, K.; Bura, R.; Lesnicki, G.; Saddler, J.; Zacchi, G. A Comparison between Simultaneous Saccharification and Fermentation and Separate Hydrolysis and Fermentation Using Steam-Pretreated Corn Stover Process Biochem. 2007, 42 (5) 834-839 10.1016/j.procbio.2007.02.003
12. Sheehan, J.; Aden, A.; Paustian, K.; Killian, K.; Brenner, J.; Walsh, M.; Nelson, R. Energy and Environmental Aspects of Using Corn Stover for Fuel Ethanol J. Ind. Ecol. 2003, 7 (3-4) 117-146 10.1162/108819803323059433
13. Aden, A.; Foust, T. Technoeconomic Analysis of the Dilute Sulfuric Acid and Enzymatic Hydrolysis Process for the Conversion of Corn Stover to Ethanol Cellulose 2009, 16 (4) 535-545 10.1007/s10570-009-9327-8
14. Kazi, F. K.; Fortman, J. A.; Anex, R. P.; Hsu, D. D.; Aden, A.; Dutta, A.; Kothandaraman, G. Techno-Economic Comparison of Process Technologies for Biochemical Ethanol Production from Corn Stover Fuel 2010, 89, S20-S28 10.1016/j.fuel.2010.01.001
15. Williams, P. R.; Inman, D.; Aden, A.; Heath, G. A. Environmental and Sustainability Factors Associated with Next-Generation Biofuels in the Us: What Do We Really Know? Environ. Sci. Technol. 2009, 43 (13) 4763-4775 10.1021/es900250d
16. Wooley, R.; Ruth, M.; Sheehan, J.; Ibsen, K.; Majdeski, H.; Galvez, A. Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis Current and Futuristic Scenarios; NREL/TP-580-26157; National Renewable Energy Laboratory: Golden, CO, 1999.
17. Aden, A.; Ruth, M.; Ibsen, K.; Jechura, J.; Neeves, K.; Sheehan, J.; Wallace, B.; Montague, L.; Slayton, A.; Lukas, J. Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis for Corn Stover; NREL/TP -510-32438; National Renewable Energy Laboratory: Golden, CO, 2002.
18. Hamelinck, C. N.; Hooijdonk, G. v.; Faaij, A. P. Ethanol from Lignocellulosic Biomass: Techno-Economic Performance in Short-, Middle-and Long-Term Biomass Bioenergy 2005, 28 (4) 384-410 10.1016/j.biombioe.2004.09.002
19. Klein-Marcuschamer, D.; Simmons, B. A.; Blanch, H. W. Techno-Economic Analysis of a Lignocellulosic Ethanol Biorefinery with Ionic Liquid Pre-Treatment Biofuels, Bioprod. Biorefin. 2011, 5 (5) 562-569 10.1002/bbb.303
20. Wright, M. M.; Brown, R. C. Comparative Economics of Biorefineries Based on the Biochemical and Thermochemical Platforms Biofuels, Bioprod. Biorefin. 2007, 1 (1) 49-56 10.1002/bbb.8
21. Sassner, P.; Galbe, M.; Zacchi, G. Techno-Economic Evaluation of Bioethanol Production from Three Different Lignocellulosic Materials Biomass Bioenergy 2008, 32 (5) 422-430 10.1016/j.biombioe.2007.10.014
22. Humbird, D.; Davis, R.; Tao, L.; Kinchin, C.; Hsu, D.; Aden, A.; Schoen, P.; Lukas, J.; Olthof, B.; Worley, M. Process Design and Economics for Biochemical Conversion of Lignocellulosic Biomass to Ethanol; NREL/TP-5100-47764; National Renewable Energy Laboratory: Golden, CO, 2011.
23. Jacobson, J. J.; Searcy, E.; Cafferty, K.; Dunn, J. B.; Johnson, M.; Wang, Z.; Wang, M.; Biddy, M.; Dutta, A.; Inman, D. Supply Chain Sustainability Analysis of Three Biofuel Pathways; ANL/ESD-14/5; Argonne National Laboratory (ANL): Argonne, IL, 2013.
24. Canter, C. E.; Dunn, J. B.; Han, J.; Wang, Z.; Wang, M. Policy Implications of Allocation Methods in the Life Cycle Analysis of Integrated Corn and Corn Stover Ethanol Production BioEnergy Res. 2016, 9 (1) 77-87 10.1007/s12155-015-9664-4
25. Murphy, C. W.; Kendall, A. Life Cycle Analysis of Biochemical Cellulosic Ethanol under Multiple Scenarios GCB Bioenergy 2015, 7 (5) 1019-1033 10.1111/gcbb.12204
26. Peralta-Yahya, P. P.; Zhang, F.; del Cardayre, S. B.; Keasling, J. D. Microbial Engineering for the Production of Advanced Biofuels Nature 2012, 488 (7411) 320-328 10.1038/nature11478
27. Serrano-Ruiz, J. C.; Dumesic, J. A. Catalytic Routes for the Conversion of Biomass into Liquid Hydrocarbon Transportation Fuels Energy Environ. Sci. 2011, 4 (1) 83-99 10.1039/C0EE00436G
28. Narula, C. K.; Li, Z.; Casbeer, E. M.; Geiger, R. A.; Moses-Debusk, M.; Keller, M.; Buchanan, M. V.; Davison, B. H., Heterobimetallic Zeolite, Inv-Zsm-5, Enables Efficient Conversion of Biomass Derived Ethanol to Renewable Hydrocarbons. Sci. Rep. 2015, 5. 16039 10.1038/srep16039
29. Mettler, M. S.; Vlachos, D. G.; Dauenhauer, P. J. Top Ten Fundamental Challenges of Biomass Pyrolysis for Biofuels Energy Environ. Sci. 2012, 5 (7) 7797-7809 10.1039/c2ee21679e
30. Luque, R.; de la Osa, A. R.; Campelo, J. M.; Romero, A. A.; Valverde, J. L.; Sanchez, P. Design and Development of Catalysts for Biomass-to-Liquid-Fischer-Tropsch (Btl-Ft) Processes for Biofuels Production Energy Environ. Sci. 2012, 5 (1) 5186-5202 10.1039/C1EE02238E
31. Van de Vyver, S.; Geboers, J.; Jacobs, P. A.; Sels, B. F. Recent Advances in the Catalytic Conversion of Cellulose ChemCatChem 2011, 3 (1) 82-94 10.1002/cctc.201000302
32. de Beeck, B. O.; Dusselier, M.; Geboers, J.; Holsbeek, J.; Morré, E.; Oswald, S.; Giebeler, L.; Sels, B. F. Direct Catalytic Conversion of Cellulose to Liquid Straight-Chain Alkanes Energy Environ. Sci. 2015, 8, 230 10.1039/C4EE01523A
33. Prasomsri, T.; Nimmanwudipong, T.; Román-Leshkov, Y. Effective Hydrodeoxygenation of Biomass-Derived Oxygenates into Unsaturated Hydrocarbons by Moo 3 Using Low H 2 Pressures Energy Environ. Sci. 2013, 6 (6) 1732-1738 10.1039/c3ee24360e
34. Rinaldi, R.; Schüth, F. Design of Solid Catalysts for the Conversion of Biomass Energy Environ. Sci. 2009, 2 (6) 610-626 10.1039/b902668a
35. Besson, M.; Gallezot, P.; Pinel, C. Conversion of Biomass into Chemicals over Metal Catalysts Chem. Rev. 2014, 114 (3) 1827-1870 10.1021/cr4002269
36. Serrano-Ruiz, J. C.; Luque, R.; Sepulveda-Escribano, A. Transformations of Biomass-Derived Platform Molecules: From High Added-Value Chemicals to Fuelsvia Aqueous-Phase Processing Chem. Soc. Rev. 2011, 40 (11) 5266-5281 10.1039/c1cs15131b
37. Lange, J.-P. Renewable Feedstocks: The Problem of Catalyst Deactivation and Its Mitigation Angew. Chem., Int. Ed. 2015, 54 (45) 13186-13197 10.1002/anie.201503595
38. Lee, S. K.; Chou, H.; Ham, T. S.; Lee, T. S.; Keasling, J. D. Metabolic Engineering of Microorganisms for Biofuels Production: From Bugs to Synthetic Biology to Fuels Curr. Opin. Biotechnol. 2008, 19 (6) 556-563 10.1016/j.copbio.2008.10.014
39. Klinke, H. B.; Thomsen, A.; Ahring, B. K. Inhibition of Ethanol-Producing Yeast and Bacteria by Degradation Products Produced During Pre-Treatment of Biomass Appl. Microbiol. Biotechnol. 2004, 66 (1) 10-26 10.1007/s00253-004-1642-2
40. Pienkos, P. T.; Zhang, M. Role of Pretreatment and Conditioning Processes on Toxicity of Lignocellulosic Biomass Hydrolysates Cellulose 2009, 16 (4) 743-762 10.1007/s10570-009-9309-x
41. Davis, R.; Tao, L.; Tan, E.; Biddy, M. J.; Beckham, G. T.; Scarlata, C.; Jacobson, J.; Cafferty, K.; Ross, J.; Lukas, J.; Knorr, D.; Schoen, P. Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbons: Dilute-Acid Prehydrolysis and Enzymatic Hydrolysis Deconstruction of Biomass to Sugars and Biological Conversion of Sugars to Hydrocarbons; NREL/TP-5100-60223; National Renewable Energy Laboratory: Golden, CO, 2013.
42. Chen, X.; Shekiro, J.; Franden, M. A.; Wang, W.; Zhang, M.; Kuhn, E.; Johnson, D. K.; Tucker, M. P. The Impacts of Deacetylation Prior to Dilute Acid Pretreatment on the Bioethanol Process Biotechnol. Biofuels 2012, 5, 8 10.1186/1754-6834-5-8
43. Liu, H.; Yu, C.; Feng, D.; Cheng, T.; Meng, X.; Liu, W.; Zou, H.; Xian, M. Production of Extracellular Fatty Acid Using Engineered Escherichia Coli Microb. Cell Fact. 2012, 11 (1) 41-54 10.1186/1475-2859-11-41
44. Meng, X.; Shang, H.; Zheng, Y.; Zhang, Z. Free Fatty Acid Secretion by an Engineered Strain of Escherichia Coli Biotechnol. Lett. 2013, 35 (12) 2099-2103 10.1007/s10529-013-1305-4
45. Michinaka, Y.; Shimauchi, T.; Aki, T.; Nakajima, T.; Kawamoto, S.; Shigeta, S.; Suzuki, O.; Ono, K. Extracellular Secretion of Free Fatty Acids by Disruption of a Fatty Acyl-Coa Synthetase Gene in Saccharomyces Cerevisiae J. Biosci. Bioeng. 2003, 95 (5) 435-440 10.1263/jbb.95.435
46. Leber, C.; Polson, B.; Fernandez-Moya, R.; Da Silva, N. A. Overproduction and Secretion of Free Fatty Acids through Disrupted Neutral Lipid Recycle in Saccharomyces Cerevisiae Metab. Eng. 2015, 28, 54-62 10.1016/j.ymben.2014.11.006
47. Scharnewski, M.; Pongdontri, P.; Mora, G.; Hoppert, M.; Fulda, M. Mutants of Saccharomyces cerevisiae Deficient in Acyl-Coa Synthetases Secrete Fatty Acids Due to Interrupted Fatty Acid Recycling FEBS J. 2008, 275 (11) 2765-2778 10.1111/j.1742-4658.2008.06417.x
48. Werpy, T.; Petersen, G.; Aden, A.; Bozell, J.; Holladay, J.; White, J.; Manheim, A.; Eliot, D.; Lasure, L.; Jones, S. Top Value Added Chemicals from Biomass. Volume 1-Results of Screening for Potential Candidates from Sugars and Synthesis Gas; Pacific Northwest National Laboratory and National Renewable Energy Laboratory, 2004.
49. Corma, A.; Iborra, S.; Velty, A. Chemical Routes for the Transformation of Biomass into Chemicals Chem. Rev. 2007, 107 (6) 2411-2502 10.1021/cr050989d
50. Bozell, J. J.; Holladay, J. E.; White, J. F.; Johnson, D. K. Top Value-Added Chemicals from Biomass. Volume II-Results of Screening for Potential Candidates from Biorefinery Lignin; Pacific Northwest National Laboratory, National Renewable Energy Laboratory, and University of Tennessee, 2007
51. Amidon, T. E.; Wood, C. D.; Shupe, A. M.; Wang, Y.; Graves, M.; Liu, S. Biorefinery: Conversion of Woody Biomass to Chemicals, Energy and Materials J. Biobased Mater. Bioenergy 2008, 2 (2) 100-120 10.1166/jbmb.2008.302
52. Bozell, J. J. Feedstocks for the Future-Biorefinery Production of Chemicals from Renewable Carbon Clean: Soil, Air, Water 2008, 36 (8) 641-647 10.1002/clen.200800100
53. Bozell, J. J.; Petersen, G. R. Technology Development for the Production of Biobased Products from Biorefinery Carbohydrates-the Us Department of Energy's ″Top 10″ Revisited Green Chem. 2010, 12 (4) 539-554 10.1039/b922014c
54. Vennestrøm, P.; Osmundsen, C. M.; Christensen, C.; Taarning, E. Beyond Petrochemicals: The Renewable Chemicals Industry Angew. Chem., Int. Ed. 2011, 50 (45) 10502-10509 10.1002/anie.201102117
55. Wettstein, S. G.; Alonso, D. M.; Gürbüz, E. I.; Dumesic, J. A. A Roadmap for Conversion of Lignocellulosic Biomass to Chemicals and Fuels Curr. Opin. Chem. Eng. 2012, 1 (3) 218-224 10.1016/j.coche.2012.04.002
56. Gallezot, P. Conversion of Biomass to Selected Chemical Products Chem. Soc. Rev. 2012, 41 (4) 1538-1558 10.1039/C1CS15147A
57. Tuck, C. O.; Pérez, E.; Horváth, I. T.; Sheldon, R. A.; Poliakoff, M. Valorization of Biomass: Deriving More Value from Waste Science 2012, 337 (6095) 695-699 10.1126/science.1218930
58. Koutinas, A. A.; Vlysidis, A.; Pleissner, D.; Kopsahelis, N.; Lopez Garcia, I.; Kookos, I. K.; Papanikolaou, S.; Kwan, T. H.; Lin, C. S. K. Valorization of Industrial Waste and by-Product Streams Via Fermentation for the Production of Chemicals and Biopolymers Chem. Soc. Rev. 2014, 43 (8) 2587-2627 10.1039/c3cs60293a
59. Dusselier, M.; Mascal, M.; Sels, B. Top Chemical Opportunities from Carbohydrate Biomass: A Chemist's View of the Biorefinery. In Selective Catalysis for Renewable Feedstocks and Chemicals; Nicholas, K. M., Ed.; Springer International Publishing: 2014; Vol. 353, pp 1-40.
60. Cheng, K.-K.; Zhao, X.-B.; Zeng, J.; Zhang, J.-A. Biotechnological Production of Succinic Acid: Current State and Perspectives Biofuels, Bioprod. Biorefin. 2012, 6 (3) 302-318 10.1002/bbb.1327
61. Tao, L.; Schell, D.; Davis, R.; Tan, E.; Elander, R. T.; Bratis, A. NREL 2012 Achievement of Ethanol Cost Targets: Biochemical Ethanol Fermentation via Dilute-Acid Pretreatment and Enzymatic Hydrolysis of Corn Stover; NREL/TP-5100-61563; National Renewable Energy Laboratory: Golden, CO, 2014.
62. Sievers, D. A.; Tao, L.; Schell, D. J. Performance and Techno-Economic Assessment of Several Solid-Liquid Separation Technologies for Processing Dilute-Acid Pretreated Corn Stover Bioresour. Technol. 2014, 167, 291-296 10.1016/j.biortech.2014.05.113
63. Runguphan, W.; Keasling, J. D. Metabolic Engineering of Saccharomyces Cerevisiae for Production of Fatty Acid-Derived Biofuels and Chemicals Metab. Eng. 2014, 21, 103-113 10.1016/j.ymben.2013.07.003
64. Davis, M. S.; Solbiati, J.; Cronan, J. E. Overproduction of Acetyl-Coa Carboxylase Activity Increases the Rate of Fatty Acid Biosynthesis in Escherichia Coli J. Biol. Chem. 2000, 275 (37) 28593-28598 10.1074/jbc.M004756200
65. Lu, X.; Vora, H.; Khosla, C. Overproduction of Free Fatty Acids in E. Coli: Implications for Biodiesel Production Metab. Eng. 2008, 10 (6) 333-339 10.1016/j.ymben.2008.08.006
66. Clomburg, J. M.; Gonzalez, R. Biofuel Production in Escherichia Coli: The Role of Metabolic Engineering and Synthetic Biology Appl. Microbiol. Biotechnol. 2010, 86 (2) 419-434 10.1007/s00253-010-2446-1
67. Beopoulos, A.; Cescut, J.; Haddouche, R.; Uribelarrea, J.-L.; Molina-Jouve, C.; Nicaud, J.-M. Yarrowia Lipolytica as a Model for Bio-Oil Production Prog. Lipid Res. 2009, 48 (6) 375-387 10.1016/j.plipres.2009.08.005
68. Tai, M.; Stephanopoulos, G. Engineering the Push and Pull of Lipid Biosynthesis in Oleaginous Yeast Yarrowia Lipolytica for Biofuel Production Metab. Eng. 2013, 15, 1-9 10.1016/j.ymben.2012.08.007
69. Blazeck, J.; Hill, A.; Liu, L.; Knight, R.; Miller, J.; Pan, A.; Otoupal, P.; Alper, H. S. Harnessing Yarrowia Lipolytica Lipogenesis to Create a Platform for Lipid and Biofuel Production Nat. Commun. 2014, 10.1038/ncomms4131
70. Li, Y.; Zhao, Z. K.; Bai, F. High-Density Cultivation of Oleaginous Yeast Rhodosporidium Toruloides Y4 in Fed-Batch Culture Enzyme Microb. Technol. 2007, 41 (3) 312-317 10.1016/j.enzmictec.2007.02.008
71. Zhu, Z.; Zhang, S.; Liu, H.; Shen, H.; Lin, X.; Yang, F.; Zhou, Y. J.; Jin, G.; Ye, M.; Zou, H.; Zhao, Z. K. A Multi-Omic Map of the Lipid-Producing Yeast Rhodosporidium Toruloides Nat. Commun. 2012, 3, 1112 10.1038/ncomms2112
72. Zhao, X.; Kong, X.; Hua, Y.; Feng, B.; Zhao, Z. K. Medium Optimization for Lipid Production through Co-Fermentation of Glucose and Xylose by the Oleaginous Yeast Lipomyces Starkeyi Eur. J. Lipid Sci. Technol. 2008, 110 (5) 405-412 10.1002/ejlt.200700224
73. Gong, Z.; Wang, Q.; Shen, H.; Hu, C.; Jin, G.; Zhao, Z. K. Co-Fermentation of Cellobiose and Xylose by Lipomyces Starkeyi for Lipid Production Bioresour. Technol. 2012, 117, 20-24 10.1016/j.biortech.2012.04.063
74. Huang, C.; Chen, X.-F.; Yang, X.-Y.; Xiong, L.; Lin, X.-Q.; Yang, J.; Wang, B.; Chen, X.-D. Bioconversion of Corncob Acid Hydrolysate into Microbial Oil by the Oleaginous Yeast Lipomyces Starkeyi Appl. Biochem. Biotechnol. 2014, 172 (4) 2197-2204 10.1007/s12010-013-0651-y
75. Laurens, L. M. L.; Nagle, N.; Davis, R.; Sweeney, N.; Van Wychen, S.; Lowell, A.; Pienkos, P. T. Acid-Catalyzed Algal Biomass Pretreatment for Integrated Lipid and Carbohydrate-Based Biofuels Production Green Chem. 2015, 17 (2) 1145-1158 10.1039/C4GC01612B
76. Dong, T.; Knoshaug, E.; Davis, R.; Laurens, L.; Wychen, S. V.; Pienkos, P. T.; Nagle, N. Combined Algal Processing: A Novel Integrated Biorefinery Process to Produce Algal Biofuels and Bioproducts Algal Res. 2016, 10.1016/j.algal.2015.12.021
77. Marker, T. L.; Petri, J.; Kalnes, T.; McCall, M.; Mackowiak, D.; Jerosky, B.; Reagan, B.; Nemeth, L.; Krawyczyk, M.; Czernik, S.; Elliott, D.; Shonnard, D. Opportunities for Biorenewables in Oil Refineries; Final Report; UOP: Des Plaines, IL, 2005.
78. Dillich, S.; Ramsden, T.; Melina, M. U.S. Department of Energy Hydrogen and Fuel Cells Program, Program Records; U.S. Department of Energy: 2012.
79. Sievers, D. A.; Lischeske, J. J.; Biddy, M. J.; Stickel, J. J. A Low-Cost Solid-Liquid Separation Process for Enzymatically Hydrolyzed Corn Stover Slurries Bioresour. Technol. 2015, 187, 37-42 10.1016/j.biortech.2015.03.087
80. Guettler, M. V.; Rumler, D.; Jain, M. K. Actinobacillus Succinogenes Sp. Nov., a Novel Succinic-Acid-Producing Strain from the Bovine Rumen Int. J. Syst. Bacteriol. 1999, 49 (1) 207-216 10.1099/00207713-49-1-207
81. Van der Werf, M. J.; Guettler, M. V.; Jain, M. K.; Zeikus, J. G. Environmental and Physiological Factors Affecting the Succinate Product Ratio During Carbohydrate Fermentation by Actinobacillus Sp. 130z Arch. Microbiol. 1997, 167 (6) 332-342 10.1007/s002030050452
82. Yu, J.; Li, Z.; Ye, Q.; Yang, Y.; Chen, S. Development of Succinic Acid Production from Corncob Hydrolysate by Actinobacillus Succinogenes J. Ind. Microbiol. Biotechnol. 2010, 37 (10) 1033-1040 10.1007/s10295-010-0750-5
83. Liu, Y.-P.; Zheng, P.; Sun, Z.-H.; Ni, Y.; Dong, J.-J.; Zhu, L.-L. Economical Succinic Acid Production from Cane Molasses by Actinobacillus Succinogenes Bioresour. Technol. 2008, 99 (6) 1736-1742 10.1016/j.biortech.2007.03.044
84. Bradfield, M. F.; Mohagheghi, A.; Salvachúa, D.; Smith, H.; Black, B. A.; Dowe, N.; Beckham, G. T.; Nicol, W. Continuous Succinic Acid Production by Actinobacillus Succinogenes on Xylose-Enriched Hydrolysate Biotechnol. Biofuels 2015, 8 (1) 1 10.1186/s13068-015-0363-3
85. Gerberding, S. J.; Singh, R., Purification of Succinic Acid from the Fermentation Broth Containing Ammonium Succinate. EP Patent EP2519491 A2, 2010.
86. Davis, R.; Tao, L.; Scarlata, C.; Tan, E. C. D.; Ross, J.; Lukas, J.; Sexton, D. Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbons: Dilute-Acid and Enzymatic Deconstruction of Biomass to Sugars and Catalytic Conversion of Sugars to Hydrocarbons; NREL/TP-5100-62498; National Renewable Energy Laboratory: Golden, CO, 2015.
87. Tan, E. C. D.; Talmadge, M.; Dutta, A.; Hensley, J.; Schaidle, J.; Biddy, M.; Humbird, D.; Snowden-Swan, L. J.; Ross, J.; Sexton, D.; Yap, R.; Lukas, J. Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbons via Indirect Liquefaction: Thermochemical Research Pathway to High-Octane Gasoline Blendstock through Methanol/Dimethyl Ether Intermediates; NREL/TP-5100-62402; National Renewable Energy Laboratory: Golden, CO, 2015.
88. Jones, S. B.; Meyer, P. A.; Snowden-Swan, L. J.; Padmaperuma, A. B.; Tan, E. C. D.; Dutta, A.; Jacobson, J.; Cafferty, K. Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Fast Pyrolysis and Hydrotreating Bio-Oil Pathway; NREL/TP-5100-61178; Pacific Northwest National Laboratory, National Renewable Energy Laboratory, and Idaho National Laboratory: 2013.
89. Galafassi, S.; Cucchetti, D.; Pizza, F.; Franzosi, G.; Bianchi, D.; Compagno, C. Lipid Production for Second Generation Biodiesel by the Oleaginous Yeast Rhodotorula Graminis Bioresour. Technol. 2012, 111, 398-403 10.1016/j.biortech.2012.02.004
90. Huang, C.; Chen, X.-f.; Xiong, L.; Yang, X.-y.; Chen, X.-d.; Ma, L.-l.; Chen, Y. Microbial Oil Production from Corncob Acid Hydrolysate by Oleaginous Yeast Trichosporon Coremiiforme Biomass Bioenergy 2013, 49, 273-278 10.1016/j.biombioe.2012.12.023
91. Huang, C.; Wu, H.; Li, R.-f.; Zong, M.-h. Improving Lipid Production from Bagasse Hydrolysate with Trichosporon Fermentans by Response Surface Methodology New Biotechnol. 2012, 29 (3) 372-378 10.1016/j.nbt.2011.03.008
92. Chang, Y.-H.; Chang, K.-S.; Hsu, C.-L.; Chuang, L.-T.; Chen, C.-Y.; Huang, F.-Y.; Jang, H.-D. A Comparative Study on Batch and Fed-Batch Cultures of Oleaginous Yeast Cryptococcus Sp. In Glucose-Based Media and Corncob Hydrolysate for Microbial Oil Production Fuel 2013, 105, 711-717 10.1016/j.fuel.2012.10.033
93. Huang, C.; Chen, X.-f.; Xiong, L.; Chen, X.-d.; Ma, L.-l. Oil Production by the Yeast Trichosporon Dermatis Cultured in Enzymatic Hydrolysates of Corncobs Bioresour. Technol. 2012, 110, 711-714 10.1016/j.biortech.2012.01.077
94. Tsigie, Y. A.; Wang, C.-Y.; Truong, C.-T.; Ju, Y.-H. Lipid Production from Yarrowia Lipolytica Po1g Grown in Sugarcane Bagasse Hydrolysate Bioresour. Technol. 2011, 102 (19) 9216-9222 10.1016/j.biortech.2011.06.047
95. Yu, X.; Zeng, J.; Zheng, Y.; Chen, S. Effect of Lignocellulose Degradation Products on Microbial Biomass and Lipid Production by the Oleaginous Yeast Cryptococcus Curvatus Process Biochem. 2014, 49 (3) 457-465 10.1016/j.procbio.2013.10.016
96. Yu, X.; Zheng, Y.; Dorgan, K. M.; Chen, S. Oil Production by Oleaginous Yeasts Using the Hydrolysate from Pretreatment of Wheat Straw with Dilute Sulfuric Acid Bioresour. Technol. 2011, 102 (10) 6134-6140 10.1016/j.biortech.2011.02.081
97. Zeng, J.; Zheng, Y.; Yu, X.; Yu, L.; Gao, D.; Chen, S. Lignocellulosic Biomass as a Carbohydrate Source for Lipid Production by Mortierella Isabellina Bioresour. Technol. 2013, 128, 385-391 10.1016/j.biortech.2012.10.079
98. Yousuf, A. Biodiesel from Lignocellulosic Biomass-Prospects and Challenges Waste Manage. 2012, 32 (11) 2061-2067 10.1016/j.wasman.2012.03.008
99. Xue, Y.-P.; Jin, M.; Orjuela, A.; Slininger, P. J.; Dien, B. S.; Dale, B. E.; Balan, V. Microbial Lipid Production from Afex[Trade Mark Sign] Pretreated Corn Stover RSC Adv. 2015, 5 (36) 28725-28734 10.1039/C5RA01134E
100. Jin, M.; Slininger, P. J.; Dien, B. S.; Waghmode, S.; Moser, B. R.; Orjuela, A.; Sousa, L. d. C.; Balan, V. Microbial Lipid-Based Lignocellulosic Biorefinery: Feasibility and Challenges Trends Biotechnol. 2015, 33 (1) 43-54 10.1016/j.tibtech.2014.11.005
101. Qiao, K.; Imam Abidi, S. H.; Liu, H.; Zhang, H.; Chakraborty, S.; Watson, N.; Kumaran Ajikumar, P.; Stephanopoulos, G. Engineering Lipid Overproduction in the Oleaginous Yeast Yarrowia Lipolytica Metab. Eng. 2015, 29, 56-65 10.1016/j.ymben.2015.02.005
102. Tabera, L.; Muñoz, R.; Gonzalez, R. Deletion of Bcy1 from the Saccharomyces Cerevisiae Genome Is Semidominant and Induces Autolytic Phenotypes Suitable for Improvement of Sparkling Wines Appl. Environ. Microbiol. 2006, 72 (4) 2351-2358 10.1128/AEM.72.4.2351-2358.2006
103. Cebollero, E.; Martinez-Rodriguez, A.; Carrascosa, A. V.; Gonzalez, R. Overexpression of Csc1-1. A Plausible Strategy to Obtain Wine Yeast Strains Undergoing Accelerated Autolysis FEMS Microbiol. Lett. 2005, 246 (1) 1-9 10.1016/j.femsle.2005.03.030
104. Salvachua, D.; Mohagheghi, A.; Smith, H.; Bradfield, M. F. A.; Nicol, W.; Black, B. A.; Biddy, M. J.; Dowe, N.; Beckham, G. T. Succinic Acid Production on Xylose-Enriched Biorefinery Streams by Actinobacillus Succinogenes in Batch Fermentation Biotechnol. Biofuels 2016, 10.1186/s13068-016-0425-1
105. Jantama, K.; Haupt, M. J.; Zhang, X.; Moore, J. C.; Shanmugam, K. T.; Ingram, L. O. N. Materials and Methods for Efficient Succinate and Malate Production. World Patent WO2008115958A3, 2014.
106. Urbanus, J.; Roelands, C. P. M.; Verdoes, D.; ter Horst, J. H. Intensified Crystallization in Complex Media: Heuristics for Crystallization of Platform Chemicals Chem. Eng. Sci. 2012, 77, 18-25 10.1016/j.ces.2012.02.019
107. Datta, R.; Glassner, D. A.; Jain, M. K.; Roy, J. R. V. Fermentation and Purification Process for Succinic Acid. U.S. Patent 5168055, 1992.
108. Xiao, H.; Shao, Z.; Jiang, Y.; Dole, S.; Zhao, H. Exploiting Issatchenkia Orientalis Sd108 for Succinic Acid Production Microb. Cell Fact. 2014, 10.1186/s12934-014-0121-4
109. de Jong, E.; Higson, A.; Walsh, P.; Wellisch, M. Product Developments in the Bio-Based Chemicals Arena Biofuels, Bioprod. Biorefin. 2012, 6 (6) 606-624 10.1002/bbb.1360
110. Guzman, D. D. Bio-Succinic Acid Market Ready to Roar ICIS Chemical Business 2012, 281 (5) 28
111. Sheldon, R. A. Green and Sustainable Manufacture of Chemicals from Biomass: State of the Art Green Chem. 2014, 16 (3) 950-963 10.1039/C3GC41935E
112. Yim, H.; Haselbeck, R.; Niu, W.; Pujol-Baxley, C.; Burgard, A.; Boldt, J.; Khandurina, J.; Trawick, J. D.; Osterhout, R. E.; Stephen, R. et al. Metabolic Engineering of Escherichia Coli for Direct Production of 1,4-Butanediol Nat. Chem. Biol. 2011, 7 (7) 445-452 10.1038/nchembio.580
113. Dusselier, M.; Van Wouwe, P.; Dewaele, A.; Makshina, E.; Sels, B. F. Lactic Acid as a Platform Chemical in the Biobased Economy: The Role of Chemocatalysis Energy Environ. Sci. 2013, 6 (5) 1415-1442 10.1039/c3ee00069a
114. Dietrich, J. US Maleic Anhydride Contracts Flat ICIS Chemical Business 2014, 285 (25) 21-21
115. Ebert, J. The Quest to Commercialize Biobased Succinic Acid. Biomass Magazine, 2007
116. Chen, X.; Wang, W.; Ciesielski, P. N.; Trass, O.; Park, S.; Tao, L.; Tucker, M. Improving Sugar Yields and Reducing Enzyme Loadings in the Deacetylation and Mechanical Refining (DMR) Process through Multi-Stage Disk and Szego Refining and Corresponding Techno Economic Analysis ACS Sustainable Chem. Eng. 2016, 4, 324 10.1021/acssuschemeng.5b01242
117. Payne, C. M.; Knott, B. C.; Mayes, H. B.; Hansson, H.; Himmel, M. E.; Sandgren, M.; Ståhlberg, J.; Beckham, G. T. Fungal Cellulases Chem. Rev. 2015, 115 (3) 1308-1448 10.1021/cr500351c
118. Ragauskas, A. J.; Beckham, G. T.; Biddy, M. J.; Chandra, R.; Chen, F.; Davis, M. F.; Davison, B. H.; Dixon, R. A.; Gilna, P.; Keller, M.; Langan, P.; Naskar, A. K.; Saddler, J. N.; Tschaplinski, T. J.; Tuskan, G. A.; Wyman, C. E. Lignin Valorization: Improving Lignin Processing in the Biorefinery Science 2014, 344 (6185) 1246843 10.1126/science.1246843
119. Linger, J. G.; Vardon, D. R.; Guarnieri, M. T.; Karp, E. M.; Hunsinger, G. B.; Franden, M. A.; Johnson, C. W.; Chupka, G.; Strathmann, T. J.; Pienkos, P. T.; Beckham, G. T. Lignin Valorization through Integrated Biological Funneling and Chemical Catalysis Proc. Natl. Acad. Sci. U. S. A. 2014, 111 (33) 12013-12018 10.1073/pnas.1410657111
120. Vardon, D. R.; Franden, M. A.; Johnson, C. W.; Karp, E. M.; Guarnieri, M. T.; Linger, J. G.; Salm, M. J.; Strathmann, T. J.; Beckham, G. T. Adipic Acid Production from Lignin Energy Environ. Sci. 2015, 8 (2) 617 10.1039/C4EE03230F
121. Zakzeski, J.; Bruijnincx, P. C. A.; Jongerius, A. L.; Weckhuysen, B. M. The Catalytic Valorization of Lignin for the Production of Renewable Chemicals Chem. Rev. 2010, 110 (6) 3552-3599 10.1021/cr900354u
122. Salvachúa, D.; Karp, E. M.; Nimlos, C. T.; Vardon, D. R.; Beckham, G. T. Towards Lignin Consolidated Bioprocessing: Simultaneous Lignin Depolymerization and Product Generation by Bacteria Green Chem. 2015, 17 (11) 4951-4967 10.1039/C5GC01165E