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Volumn 21, Issue , 2014, Pages 103-113

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals

Author keywords

Biodiesels; Fatty acids; Fatty alcohols; Metabolic engineering; Triacylglycerols; Yeast

Indexed keywords

BIOCHEMISTRY; BIODIESEL; CHEMICALS; CLIMATE CHANGE; GLYCEROL; METABOLIC ENGINEERING; SUGARS; SYNTHETIC FUELS; YEAST;

EID: 84891829362     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2013.07.003     Document Type: Article
Times cited : (330)

References (54)
  • 1
    • 85067777155 scopus 로고    scopus 로고
    • Renewable Fuel Standards. In: Agency, U.E.P., (Ed.). US Environmental Protection Agency.
    • Agency, U.E.P., 2012. Renewable Fuel Standards. In: Agency, U.E.P., (Ed.). US Environmental Protection Agency.
    • (2012)
    • Agency, U.E.P.1
  • 2
    • 0026562139 scopus 로고
    • Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase
    • Al-Feel W., Chirala S.S., Wakil S.J. Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase. Proc. Natl. Acad. Sci. USA 1992, 89:4534-4538.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4534-4538
    • Al-Feel, W.1    Chirala, S.S.2    Wakil, S.J.3
  • 4
    • 0021668558 scopus 로고
    • A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
    • Boeke J.D., LaCroute F., Fink G.R. A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet.: MGG 1984, 197:345-346.
    • (1984) Mol. Gen. Genet.: MGG , vol.197 , pp. 345-346
    • Boeke, J.D.1    LaCroute, F.2    Fink, G.R.3
  • 6
    • 4444258170 scopus 로고    scopus 로고
    • Mammalian wax biosynthesis. I. Identification of two fatty acyl-coenzyme A reductases with different substrate specificities and tissue distributions
    • Cheng J.B., Russell D.W. Mammalian wax biosynthesis. I. Identification of two fatty acyl-coenzyme A reductases with different substrate specificities and tissue distributions. J. Biol. Chem. 2004, 279:37789-37797.
    • (2004) J. Biol. Chem. , vol.279 , pp. 37789-37797
    • Cheng, J.B.1    Russell, D.W.2
  • 7
    • 0034612345 scopus 로고    scopus 로고
    • Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
    • Dahlqvist A., Stahl U., Lenman M., Banas A., Lee M., Sandager L., Ronne H., Stymne S. Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants. Proc. Natl. Acad. Sci. USA 2000, 97:6487-6492.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6487-6492
    • Dahlqvist, A.1    Stahl, U.2    Lenman, M.3    Banas, A.4    Lee, M.5    Sandager, L.6    Ronne, H.7    Stymne, S.8
  • 8
    • 0034666431 scopus 로고    scopus 로고
    • Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli
    • Davis M.S., Solbiati J., Cronan J.E. Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli. J. Biol. Chem. 2000, 275:28593-28598.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28593-28598
    • Davis, M.S.1    Solbiati, J.2    Cronan, J.E.3
  • 9
    • 80051941601 scopus 로고    scopus 로고
    • Engineered reversal of the [beta]-oxidation cycle for the synthesis of fuels and chemicals
    • Dellomonaco C., Clomburg J.M., Miller E.N., Gonzalez R. Engineered reversal of the [beta]-oxidation cycle for the synthesis of fuels and chemicals. Nature 2011, 476:355-359.
    • (2011) Nature , vol.476 , pp. 355-359
    • Dellomonaco, C.1    Clomburg, J.M.2    Miller, E.N.3    Gonzalez, R.4
  • 10
    • 0025335782 scopus 로고
    • Structure and transcriptional control of the Saccharomyces cerevisiae POX1 gene encoding acyl-coenzyme A oxidase
    • Dmochowska A., Dignard D., Maleszka R., Thomas D.Y. Structure and transcriptional control of the Saccharomyces cerevisiae POX1 gene encoding acyl-coenzyme A oxidase. Gene 1990, 88:247-252.
    • (1990) Gene , vol.88 , pp. 247-252
    • Dmochowska, A.1    Dignard, D.2    Maleszka, R.3    Thomas, D.Y.4
  • 11
    • 65049083862 scopus 로고    scopus 로고
    • Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coli
    • Doan T.T., Carlsson A.S., Hamberg M., Bulow L., Stymne S., Olsson P. Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coli. J. Plant Physiol. 2009, 166:787-796.
    • (2009) J. Plant Physiol. , vol.166 , pp. 787-796
    • Doan, T.T.1    Carlsson, A.S.2    Hamberg, M.3    Bulow, L.4    Stymne, S.5    Olsson, P.6
  • 12
    • 0025767818 scopus 로고
    • Regulation of transcription of the gene coding for peroxisomal 3-oxoacyl-CoA thiolase of Saccharomyces cerevisiae
    • Einerhand A.W., Voorn-Brouwer T.M., Erdmann R., Kunau W.H., Tabak H.F. Regulation of transcription of the gene coding for peroxisomal 3-oxoacyl-CoA thiolase of Saccharomyces cerevisiae. Eur. J. Biochem. 1991, 200:113-122.
    • (1991) Eur. J. Biochem. , vol.200 , pp. 113-122
    • Einerhand, A.W.1    Voorn-Brouwer, T.M.2    Erdmann, R.3    Kunau, W.H.4    Tabak, H.F.5
  • 14
    • 34347260322 scopus 로고    scopus 로고
    • Frozen competent yeast cells that can be transformed with high efficiency using the LiAc/SS carrier DNA/PEG method
    • Gietz R.D., Schiestl R.H. Frozen competent yeast cells that can be transformed with high efficiency using the LiAc/SS carrier DNA/PEG method. Nat. Protoc. 2007, 2:1-4.
    • (2007) Nat. Protoc. , vol.2 , pp. 1-4
    • Gietz, R.D.1    Schiestl, R.H.2
  • 15
    • 34347206860 scopus 로고    scopus 로고
    • High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method
    • Gietz R.D., Schiestl R.H. High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat. Protoc. 2007, 2:31-34.
    • (2007) Nat. Protoc. , vol.2 , pp. 31-34
    • Gietz, R.D.1    Schiestl, R.H.2
  • 16
    • 0037088811 scopus 로고    scopus 로고
    • A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast
    • Gueldener U., Heinisch J., Koehler G.J., Voss D., Hegemann J.H. A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast. Nucl. Acids Res. 2002, 30:e23.
    • (2002) Nucl. Acids Res. , vol.30
    • Gueldener, U.1    Heinisch, J.2    Koehler, G.J.3    Voss, D.4    Hegemann, J.H.5
  • 17
    • 85067757879 scopus 로고    scopus 로고
    • Dynamics of the Global Fatty Alcohol Market.
    • Gupta, S., 2004. Dynamics of the Global Fatty Alcohol Market.
    • (2004)
    • Gupta, S.1
  • 18
    • 80052919515 scopus 로고    scopus 로고
    • Delete and repeat: a comprehensive toolkit for sequential gene knockout in the budding yeast Saccharomyces cerevisiae
    • Hegemann J.H., Heick S.B. Delete and repeat: a comprehensive toolkit for sequential gene knockout in the budding yeast Saccharomyces cerevisiae. Methods Mol. Biol. 2011, 765:189-206.
    • (2011) Methods Mol. Biol. , vol.765 , pp. 189-206
    • Hegemann, J.H.1    Heick, S.B.2
  • 19
    • 33746655320 scopus 로고    scopus 로고
    • Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels
    • Hill J., Nelson E., Tilman D., Polasky S., Tiffany D. Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels. Proc. Natl Acad. Sci. USA 2006, 103:11206-11210.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 11206-11210
    • Hill, J.1    Nelson, E.2    Tilman, D.3    Polasky, S.4    Tiffany, D.5
  • 20
    • 0026713679 scopus 로고
    • Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product
    • Hiltunen J.K., Wenzel B., Beyer A., Erdmann R., Fossa A., Kunau W.H. Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. J. Biol. Chem. 1992, 267:6646-6653.
    • (1992) J. Biol. Chem. , vol.267 , pp. 6646-6653
    • Hiltunen, J.K.1    Wenzel, B.2    Beyer, A.3    Erdmann, R.4    Fossa, A.5    Kunau, W.H.6
  • 21
    • 0032965889 scopus 로고    scopus 로고
    • Cloning of a cDNA encoding diacylglycerol acyltransferase from Arabidopsis thaliana and its functional expression
    • Hobbs D.H., Lu C., Hills M.J. Cloning of a cDNA encoding diacylglycerol acyltransferase from Arabidopsis thaliana and its functional expression. FEBS Lett. 1999, 452:145-149.
    • (1999) FEBS Lett. , vol.452 , pp. 145-149
    • Hobbs, D.H.1    Lu, C.2    Hills, M.J.3
  • 23
    • 0034972852 scopus 로고    scopus 로고
    • Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight
    • Jako C., Kumar A., Wei Y., Zou J., Barton D.L., Giblin E.M., Covello P.S., Taylor D.C. Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight. Plant Physiol. 2001, 126:861-874.
    • (2001) Plant Physiol. , vol.126 , pp. 861-874
    • Jako, C.1    Kumar, A.2    Wei, Y.3    Zou, J.4    Barton, D.L.5    Giblin, E.M.6    Covello, P.S.7    Taylor, D.C.8
  • 24
    • 0015252934 scopus 로고
    • Influence of glucose concentration on the physiology and lipid composition of some yeasts
    • Johnson B., Nelson S.J., Brown C.M. Influence of glucose concentration on the physiology and lipid composition of some yeasts. Antonie van Leeuwenhoek 1972, 38:129-136.
    • (1972) Antonie van Leeuwenhoek , vol.38 , pp. 129-136
    • Johnson, B.1    Nelson, S.J.2    Brown, C.M.3
  • 25
    • 10444228204 scopus 로고    scopus 로고
    • Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase
    • Kalscheuer R., Luftmann H., Steinbuchel A. Synthesis of novel lipids in Saccharomyces cerevisiae by heterologous expression of an unspecific bacterial acyltransferase. Appl. Environ. Microbiol. 2004, 70:7119-7125.
    • (2004) Appl. Environ. Microbiol. , vol.70 , pp. 7119-7125
    • Kalscheuer, R.1    Luftmann, H.2    Steinbuchel, A.3
  • 26
    • 33645232394 scopus 로고    scopus 로고
    • Identification of genes affecting lipid content using transposon mutagenesis in Saccharomyces cerevisiae
    • Kamisaka Y., Noda N., Tomita N., Kimura K., Kodaki T., Hosaka K. Identification of genes affecting lipid content using transposon mutagenesis in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 2006, 70:646-653.
    • (2006) Biosci. Biotechnol. Biochem. , vol.70 , pp. 646-653
    • Kamisaka, Y.1    Noda, N.2    Tomita, N.3    Kimura, K.4    Kodaki, T.5    Hosaka, K.6
  • 27
    • 36348956692 scopus 로고    scopus 로고
    • DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Deltasnf2 disruptant of Saccharomyces cerevisiae
    • Kamisaka Y., Tomita N., Kimura K., Kainou K., Uemura H. DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Deltasnf2 disruptant of Saccharomyces cerevisiae. Biochem. J. 2007, 408:61-68.
    • (2007) Biochem. J. , vol.408 , pp. 61-68
    • Kamisaka, Y.1    Tomita, N.2    Kimura, K.3    Kainou, K.4    Uemura, H.5
  • 29
    • 77953022686 scopus 로고    scopus 로고
    • Quantitative analysis and engineering of fatty acid biosynthesis in E
    • Liu, T., Vora, H., Khosla, C., 2010. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metab. Eng. 12, 378-386.
    • (2010) coli. Metab. Eng. , vol.2 , pp. 378-386
    • Liu, T.1    Vora, H.2    Khosla, C.3
  • 30
    • 17144461521 scopus 로고    scopus 로고
    • Bacteriophage contamination: is there a simple method to reduce its deleterious effects in laboratory cultures and biotechnological factories?
    • Los M., Czyz A., Sell E., Wegrzyn A., Neubauer P., Wegrzyn G. Bacteriophage contamination: is there a simple method to reduce its deleterious effects in laboratory cultures and biotechnological factories?. J. Appl. Genet. 2004, 45:111-120.
    • (2004) J. Appl. Genet. , vol.45 , pp. 111-120
    • Los, M.1    Czyz, A.2    Sell, E.3    Wegrzyn, A.4    Neubauer, P.5    Wegrzyn, G.6
  • 31
    • 57049105699 scopus 로고    scopus 로고
    • Overproduction of free fatty acids in E. coli: implications for biodiesel production
    • Lu X., Vora H., Khosla C. Overproduction of free fatty acids in E. coli: implications for biodiesel production. Metab. Eng. 2008, 10:333-339.
    • (2008) Metab. Eng. , vol.10 , pp. 333-339
    • Lu, X.1    Vora, H.2    Khosla, C.3
  • 34
    • 0033759056 scopus 로고    scopus 로고
    • Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed
    • Metz J.G., Pollard M.R., Anderson L., Hayes T.R., Lassner M.W. Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed. Plant Physiol. 2000, 122:635-644.
    • (2000) Plant Physiol. , vol.122 , pp. 635-644
    • Metz, J.G.1    Pollard, M.R.2    Anderson, L.3    Hayes, T.R.4    Lassner, M.W.5
  • 35
    • 6044273857 scopus 로고    scopus 로고
    • Manipulation of malic enzyme in Saccharomyces cerevisiae for increasing NADPH production capacity aerobically in different cellular compartments
    • Moreira dos Santos M., Raghevendran V., Kotter P., Olsson L., Nielsen J. Manipulation of malic enzyme in Saccharomyces cerevisiae for increasing NADPH production capacity aerobically in different cellular compartments. Metab. Eng. 2004, 6:352-363.
    • (2004) Metab. Eng. , vol.6 , pp. 352-363
    • Moreira dos Santos, M.1    Raghevendran, V.2    Kotter, P.3    Olsson, L.4    Nielsen, J.5
  • 36
    • 33747376106 scopus 로고    scopus 로고
    • Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae
    • Nevoigt E., Kohnke J., Fischer C.R., Alper H., Stahl U., Stephanopoulos G. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2006, 72:5266-5273.
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 5266-5273
    • Nevoigt, E.1    Kohnke, J.2    Fischer, C.R.3    Alper, H.4    Stahl, U.5    Stephanopoulos, G.6
  • 37
    • 0017879460 scopus 로고
    • Inhibition of rat-liver acetyl-coenzyme-A carboxylase by palmitoyl-coenzyme A. Formation of equimolar enzyme-inhibitor complex
    • Ogiwara H., Tanabe T., Nikawa J., Numa S. Inhibition of rat-liver acetyl-coenzyme-A carboxylase by palmitoyl-coenzyme A. Formation of equimolar enzyme-inhibitor complex. Eur. J. Biochem./FEBS 1978, 89:33-41.
    • (1978) Eur. J. Biochem./FEBS , vol.89 , pp. 33-41
    • Ogiwara, H.1    Tanabe, T.2    Nikawa, J.3    Numa, S.4
  • 38
    • 0026020420 scopus 로고
    • Vectors for expression of cloned genes in yeast: regulation, overproduction, and underproduction
    • Schneider J.C., Guarente L. Vectors for expression of cloned genes in yeast: regulation, overproduction, and underproduction. Methods Enzymol. 1991, 194:373-388.
    • (1991) Methods Enzymol. , vol.194 , pp. 373-388
    • Schneider, J.C.1    Guarente, L.2
  • 39
    • 4544275674 scopus 로고    scopus 로고
    • Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems
    • Schweizer E., Hofmann J. Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems. Microbiol. Mol. Biol. Rev.: MMBR 2004, 68:501-517.
    • (2004) Microbiol. Mol. Biol. Rev.: MMBR , vol.68 , pp. 501-517
    • Schweizer, E.1    Hofmann, J.2
  • 40
    • 0029969114 scopus 로고    scopus 로고
    • A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters
    • Shani N., Valle D. A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc. Natl. Acad. Sci. USA 1996, 93:11901-11906.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11901-11906
    • Shani, N.1    Valle, D.2
  • 41
    • 84857243863 scopus 로고    scopus 로고
    • Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production
    • Shi S., Valle-Rodriguez J.O., Khoomrung S., Siewers V., Nielsen J. Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production. Biotechnol. Biofuels 2012, 5:7.
    • (2012) Biotechnol. Biofuels , vol.5 , pp. 7
    • Shi, S.1    Valle-Rodriguez, J.O.2    Khoomrung, S.3    Siewers, V.4    Nielsen, J.5
  • 42
    • 75749125061 scopus 로고    scopus 로고
    • Microbial production of fatty-acid-derived fuels and chemicals from plant biomass
    • Steen E.J. Microbial production of fatty-acid-derived fuels and chemicals from plant biomass. Nature 2010, 463:559-562.
    • (2010) Nature , vol.463 , pp. 559-562
    • Steen, E.J.1
  • 44
    • 14544268951 scopus 로고    scopus 로고
    • The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase
    • Stoveken T., Kalscheuer R., Malkus U., Reichelt R., Steinbuchel A. The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase. J. Bacteriol. 2005, 187:1369-1376.
    • (2005) J. Bacteriol. , vol.187 , pp. 1369-1376
    • Stoveken, T.1    Kalscheuer, R.2    Malkus, U.3    Reichelt, R.4    Steinbuchel, A.5
  • 45
    • 84870674137 scopus 로고    scopus 로고
    • Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production
    • Tai M., Stephanopoulos G. Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production. Metab. Eng. 2013, 15:1-9.
    • (2013) Metab. Eng. , vol.15 , pp. 1-9
    • Tai, M.1    Stephanopoulos, G.2
  • 46
    • 84874556188 scopus 로고    scopus 로고
    • Metabolic engineering for enhanced fatty acids synthesis in Saccharomyces cerevisiae
    • Tang X., Feng H., Chen W.N. Metabolic engineering for enhanced fatty acids synthesis in Saccharomyces cerevisiae. Metab. Eng. 2013, 16:95-102.
    • (2013) Metab. Eng. , vol.16 , pp. 95-102
    • Tang, X.1    Feng, H.2    Chen, W.N.3
  • 48
    • 0034933704 scopus 로고    scopus 로고
    • The genetics of fatty acid metabolism in Saccharomyces cerevisiae
    • Trotter P.J. The genetics of fatty acid metabolism in Saccharomyces cerevisiae. Annu. Rev. Nutr. 2001, 21:97-119.
    • (2001) Annu. Rev. Nutr. , vol.21 , pp. 97-119
    • Trotter, P.J.1
  • 49
    • 0031127392 scopus 로고    scopus 로고
    • Resolution and purification of an aldehyde-generating and an alcohol-generating fatty acyl-CoA reductase from pea leaves (Pisum sativum L.)
    • Vioque J., Kolattukudy P.E. Resolution and purification of an aldehyde-generating and an alcohol-generating fatty acyl-CoA reductase from pea leaves (Pisum sativum L.). Arch. Biochem. Biophys. 1997, 340:64-72.
    • (1997) Arch. Biochem. Biophys. , vol.340 , pp. 64-72
    • Vioque, J.1    Kolattukudy, P.E.2
  • 51
    • 0032870365 scopus 로고    scopus 로고
    • The role of malic enzyme in the regulation of lipid accumulation in filamentous fungi
    • Wynn J.P., bin Abdul Hamid A., Ratledge C. The role of malic enzyme in the regulation of lipid accumulation in filamentous fungi. Microbiology. 1999, 145(Part 8):1911-1917.
    • (1999) Microbiology. , vol.145 , Issue.PART 8 , pp. 1911-1917
    • Wynn, J.P.1    Bin Abdul Hamid, A.2    Ratledge, C.3
  • 52
    • 84877804801 scopus 로고    scopus 로고
    • Modular optimization of multi-gene pathways for fatty acids production in E. coli
    • Xu P., Gu Q., Wang W., Wong L., Bower A.G., Collins C.H., Koffas M.A. Modular optimization of multi-gene pathways for fatty acids production in E. coli. Nat. Commun. 2013, 4:1409.
    • (2013) Nat. Commun. , vol.4 , pp. 1409
    • Xu, P.1    Gu, Q.2    Wang, W.3    Wong, L.4    Bower, A.G.5    Collins, C.H.6    Koffas, M.A.7
  • 53
    • 81455143861 scopus 로고    scopus 로고
    • Synthesis of FAEEs from glycerol in engineered Saccharomyces cerevisiae using endogenously produced ethanol by heterologous expression of an unspecific bacterial acyltransferase
    • Yu K.O., Jung J., Kim S.W., Park C.H., Han S.O. Synthesis of FAEEs from glycerol in engineered Saccharomyces cerevisiae using endogenously produced ethanol by heterologous expression of an unspecific bacterial acyltransferase. Biotechnol. Bioeng. 2012, 109:110-115.
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 110-115
    • Yu, K.O.1    Jung, J.2    Kim, S.W.3    Park, C.H.4    Han, S.O.5
  • 54
    • 34447550704 scopus 로고    scopus 로고
    • Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation
    • Zhang Y., Adams I.P., Ratledge C. Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation. Microbiology 2007, 153:2013-2025.
    • (2007) Microbiology , vol.153 , pp. 2013-2025
    • Zhang, Y.1    Adams, I.P.2    Ratledge, C.3


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